Metabolic Alterations Following Thermal Burns. Vii. Effect of Force-Feeding, Methionine, and Testosterone Propionate on Nitrogen Balance in Experimental Burns 1

Meyer, Frieda L.; Hirshfeld, John W.; Abbott, William E.

doi:10.1172/jci101862

Cited by 15 publications

(1 citation statement)

References 6 publications

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“…The evidence is now weighted against methionine having an effect in diminishing the negative nitrogen balance in burns where the previous diet is not deficient in methionine but yet the loss of cystine is quite considerable (Gribble, .Peters, and Wakelin, 1947;Sellers and Best, 1947;Meyer, Hirshfeld, and Abbot, 1947). Emerson and Binkley (1946) have reported a retention of nitrogen in a few cases in which the ten amino-acids which are essential for the growth of the rat were given intravenously.…”

Section: Protein Regeneration Following Partial Starvationmentioning

confidence: 99%

Significance of Proteins in Nutrition

Cuthbertson¹

1949

BMJ

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Section: Protein Regeneration Following Partial Starvationmentioning

confidence: 99%

Significance of Proteins in Nutrition

Cuthbertson¹

1949

BMJ

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Testosterone Propionate as a Nitrogen-Sparing Agent After Spinal Cord Injury

Cooper¹

1951

JAMA

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Amino‐acids and protein hydrolysates in human and animal nutrition

Cuthbertson¹

1950

J Sci Food Agric

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THE roles played by the body proteins in the architecture of function and in function itself are bound up with their peculiar physico-chemical properties. The nutritionist, however, is particularly concerned with the supply of sufficient protein containing the requisite amino-acids and possibly certain peptides which the body cannot itself synthesize or can synthesize only at a rate which does not meet the full requirements for growth, reproduction, maintenance of health and the strain of illness.It is inappropriate here to delve into the contributions of the long list of workers from the time of Willcocks and Hopkins, Osborne and Mendel to the present day, who have investigated the nutritional role of the amino-acids, but reference must be made to Rose's latest account' of work in this field. He has found that for maintenance of nitrogen balance man requires eight amino-acids preformed in his diet ; these are L-tryptophan (0.25 g.), L-phenylalanine (1.10 g.), L-methionine (1.10 g.), L-leucine (1.10 g.), L-isoleucine (0.70 g.), L-valine (0.80 g.), L-threonine (0.50 g.), and L-lysine (0.80 g.). (Rose's assessment of the minimum daily requirements of each for the adult is indicated in parentheses, but he recommends as the daily intake twice these amounts.) For the growing human organism histidine and arginine are probably necessary, and it may be that some of the aminoacids thought at present to be dispensable may be necessary if the synthetic capacity 1s liable to be overtaxed. The human requirements of amino-acids for pregnancy and lactation or for different forms of illness are still not known. Rose has found disconcerting differences in the minimum amount of amino-acid required by different individuals under comparable experimental conditions : with certain amino-acids the results are consistent, with others there may be as much as a IOO per cent difference. It is also necessary to point out that for the bird the glycine and glutamic acid requirements for growth are so high that they become essential amino-acids.2, 3, 4, 5 , 5aThe proteins of the food are the normal exogenous supply of those amino-acids and specific groupings required by the body. After ingestion the proteins are digested by the hydrolytic processes of the alimentary tract and the amino-acids so formed are then absorbed (possible exceptions are homologous plasma proteinss). In the lamb there is evidence that antibody protein is absorbed from the colostrum in considerable amount up to 48 hours after birth.' While the body has the faculty of synthesizing certain of these amino-acids or specific groups, others cannot be synthesized at all or only at a very slow rate. Diets must therefore contain proteins which act in a supplementary fashion by supplying these essential amino-acids and in certain instances peptide fragments so that no key factor of protein origin is lacking, otherwise limitation in growth or other functions will be manifest. Credit for pointing out the supplemental action of the proteins, not only in individual foodstuffs but in th...

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Metabolic Alterations Following Thermal Burns. Vii. Effect of Force-Feeding, Methionine, and Testosterone Propionate on Nitrogen Balance in Experimental Burns 1

Cited by 15 publications

References 6 publications

Significance of Proteins in Nutrition

Significance of Proteins in Nutrition

Testosterone Propionate as a Nitrogen-Sparing Agent After Spinal Cord Injury

Amino‐acids and protein hydrolysates in human and animal nutrition

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