Metabolic adaptations in pressure overload hypertrophic heart

Wei, Jinfeng; Duan, Xuefei; Chen, Jiaying; Zhang, Dengwen; Xu, Jindong; Zhuang, Jian; Wang, Sheng

doi:10.1007/s10741-023-10353-y

Heart Fail Rev

2023

DOI: 10.1007/s10741-023-10353-y

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Metabolic adaptations in pressure overload hypertrophic heart

Jinfeng Wei,

Xuefei Duan,

Jiaying Chen

et al.

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2024

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Cited by 1 publication

References 189 publications

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Female Specific Restrictive Cardiomyopathy and Metabolic Dysregulation in transgenic mice expressing a Peptide of the Amino-Terminus of GRK2

Bledzka,

Manaserh,

Ifft

et al. 2024

Preprint

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Cardiovascular disease and heart failure are a major health challenge, with sex differences in pathophysiology and treatment responses critically influencing patient outcomes. G protein-coupled receptor (GPCR) kinase 2 (GRK2) is a pivotal regulator of cellular signaling whose elevation is a hallmark of heart failure progression. Its complex network of protein interactions impact a wide range of physiological and pathophysiological processes including cardiac function. In this study, we examined the effects of cardiac-restricted expression of an amino-terminal peptide of GRK2 (βARKnt) in female mice subjected to acute and chronic pressure overload. Our findings reveal that that βARKnt affects hypertrophy development and cardiac function differently in female mice than in males, leading to a transition to heart failure not observed in control females or βARKnt males. Notably, the βARKnt female mice exhibited baseline hypertrophy with distinct left atrial morphology, increased fibrosis, and immune cell infiltration compared to the controls, which progressed under chronic stress, indicating adverse cardiac remodeling. Furthermore, βARKnt female mice, unlike males, exhibit impaired tissue respiration following acute pressure overload and altered glucose sensitivity and insulin tolerance, highlighting significant remodeling of cardiac and systemic metabolism.

show abstract

Female Specific Restrictive Cardiomyopathy and Metabolic Dysregulation in transgenic mice expressing a Peptide of the Amino-Terminus of GRK2

Bledzka,

Manaserh,

Ifft

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

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Metabolic adaptations in pressure overload hypertrophic heart

Cited by 1 publication

References 189 publications

Female Specific Restrictive Cardiomyopathy and Metabolic Dysregulation in transgenic mice expressing a Peptide of the Amino-Terminus of GRK2

Female Specific Restrictive Cardiomyopathy and Metabolic Dysregulation in transgenic mice expressing a Peptide of the Amino-Terminus of GRK2

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