Metabolic Acidosis with Ophthalmic Dorzolamide in a Neonate

Capino, Amanda C.; Dannaway, Douglas; Miller, Jamie L.

doi:10.5863/1551-6776-21.3.256

Cited by 5 publications

(4 citation statements)

References 8 publications

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“…Sight. CA inhibitors applied as eye drops have long been used to treat glaucoma by virtue of their ability to reduce the production of aqueous humor, although even their localized ophthalmic use has been documented to lead to the side-effect of systemic MAc in some prone individuals [144] , [145] . Corneal edema that results from the expression of mutant misfolded SLC4A11 may be amenable to correction by small molecule folding chaperones [146] .…”

Section: Applications By Organ Systemmentioning

confidence: 99%

The therapeutic importance of acid-base balance

Quade

Parker

Occhipinti

2021

Biochemical Pharmacology

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Baking soda and vinegar have been used as home remedies for generations and today we are only a mouse-click away from claims that baking soda, lemon juice, and apple cider vinegar are miracles cures for everything from cancer to COVID-19. Despite these specious claims, the therapeutic value of controlling acid-base balance is indisputable and is the basis of Food and Drug Administration-approved treatments for constipation, epilepsy, metabolic acidosis, and peptic ulcers. In this narrative review, we present evidence in support of the current and potential therapeutic value of countering local and systemic acid-base imbalances, several of which do in fact involve the administration of baking soda (sodium bicarbonate). Furthermore, we discuss the side effects of pharmaceuticals on acid-base balance as well as the influence of acid-base status on pharmacokinetic properties of drugs. Our review considers all major organs systems as well as information relevant to several clinical specialties such as anesthesiology, infectious disease, oncology, dentistry, and surgery.

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Section: Applications By Organ Systemmentioning

confidence: 99%

The therapeutic importance of acid-base balance

Quade

Parker

Occhipinti

2021

Biochemical Pharmacology

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“… 51 , 52 A case of normal anion gap metabolic acidosis in a premature neonate who was on topical dorzolamide, betaxolol, and latanoprost for bilateral congenital glaucoma has also been reported. 53 Although upon discontinuation of the dorzolamide ophthalmic solution, the metabolic acidosis gradually resolved. Thus dorzolamide was suspected to be the primary cause of a normal gap acidosis.…”

Section: Treatment Optionsmentioning

confidence: 99%

Management of glaucoma in pregnancy – balancing safety with efficacy

et al. 2021

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Glaucoma and pregnancy is an uncommon combination, but it constitutes a very challenging situation for the treating doctor. The challenge is not only controlling the intraocular pressure and preventing glaucoma progression in the mother, but also having to deal with her mental stress and anxiety regarding the safety of her child. The situation is further worsened by the lack of definite guidelines as to how to deal with such patients. Relative rarity of glaucoma in this population restricts any large prospective randomized clinical trials or any large systematic studies. Moreover, none of the existing anti-glaucoma medications is absolutely safe in pregnancy. Current practice patterns depend on some case reports, a few observational studies and a few animal studies that attempt at determining the safety and efficacy of the available medicines. These are then prescribed on the basis of their relative safety in any particular stage of pregnancy or lactation. Newer medications that were released recently in 2018, such as Vyzulta and Rhopressa, presently have limited data to support their safety for use during pregnancy. Laser trabeculoplasty, conventional filtration surgery (of course without anti-metabolites), and minimally invasive glaucoma surgery represent a few non-pharmacological management options. Surgical procedures such as trabeculectomy and tube-shunts or collagen matrix implants, and newer minimally invasive glaucoma surgery procedures such as the gelatin stents are currently being explored and may prove to be viable solutions for severe glaucoma during pregnancy, although they too have their own inherent drawbacks. Management of glaucoma during pregnancy and lactation requires careful consideration of the disease status, gestational stage, US Food and Drug Administration classification and guidelines, and potential benefits and limitations of the various therapeutic modalities. This review focuses on the importance of a multidisciplinary team approach, starting with preconception planning and counseling, determining the treatment options depending on the stage of glaucoma and of pregnancy, and emphasizes the involvement of the patients, their obstetrician, and pediatrician through active discussion regarding the various medical, laser, or surgical modalities currently available or under exploration for use during pregnancy and lactation. The ultimate aim is to achieve an optimal balance between the risks and benefits of any type of intervention, and to customize treatment on an individual basis in order to achieve the best outcomes for both mother and fetus.

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“…Warsham et al [7] published the case report of a newborn with sacrococcygeal teratoma whose mother used acetazolamide throughout her pregnancy. There is also a risk of metabolic disorders in newborns if the mother used acetazolamide whilst pregnant [8].…”

Section: Glaucoma Pharmacotherapymentioning

confidence: 99%

Ophthalmological problems in pregnancy — a review

Rzeszotarska¹,

Szczapa-Jagustyn²,

Kocięcki³

2020

Ginekol Pol

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Pregnancy is associated with numerous changes affecting all organs. Ophthalmological changes in pregnant women are most often physiological and resolve spontaneously after delivery. However, the possibility of progression of previously diagnosed ophthalmic diseases or the occurrence of ophthalmological complications in the course of diseases characteristic for pregnancy should always be considered.

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Metabolic Acidosis with Ophthalmic Dorzolamide in a Neonate

Cited by 5 publications

References 8 publications

The therapeutic importance of acid-base balance

The therapeutic importance of acid-base balance

Management of glaucoma in pregnancy – balancing safety with efficacy

Ophthalmological problems in pregnancy — a review

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