Metabolic acidosis in patients receiving anticonvulsants

Multiple Leukocyte Abnormalities in Chronic Granulomatous Disease: A Familial Study

“…>. glutathionc peroxidase was first described in females with CGD (18), and subsequently in a male child with this syndrome (24). In contrast to the present studies, however, a !ability of G-6-PD was not detected.…”

“…The present report represents the first description of neutrophil dysfunction in a family in association with multiple deficiencies of leukocyte L ' nzymes . Although diminished leukocyte glutathionc peroxidase has been observed in both male (24) and km ale ( 18) patients with CGD, the unique finding of leukoc yte G-6-PD )ability together with several leukocyte enzyme defects has not been previously d escribed . Furthermore.…”

“…Originally described in males as a syndrome with an X-linked mode of transmission (lJ, IO,34). CG D has been described in male and female patients with an autosomal recessive mode of inheritance (18,24,28). A myriad of leukocyte enzyme deficiencies have been described.…”

“…A myriad of leukocyte enzyme deficiencies have been described. The entity has been associated with G-6-PD !ability (6) or deficiency (I) in males, with glutathione peroxidase deficiency in females ( 18) and males (24 ). with diminished NADH oxidase (2) and NADPH oxidase activitv (16), and with decreased superoxide production (13).…”