Metabolic acidosis in chronic kidney disease: mere consequence or also culprit?
Christian Kuhn,
Nilufar Mohebbi,
Alexander Ritter
Abstract:Metabolic acidosis is a frequent complication in non-transplant chronic kidney disease (CKD) and after kidney transplantation. It occurs when net endogenous acid production exceeds net acid excretion. While nephron loss with reduced ammoniagenesis is the main cause of acid retention in non-transplant CKD patients, additional pathophysiological mechanisms are likely inflicted in kidney transplant recipients. Functional tubular damage by calcineurin inhibitors seems to play a key role causing renal tubular acido… Show more
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