Metabolic abnormalities: triglyceride and low-density lipoprotein

Krauss, Ronald M.; Siri, Patty W.

doi:10.1016/j.ecl.2004.03.016

Cited by 93 publications

(81 citation statements)

References 54 publications

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“…87,88,89,90 As lowdensity lipoprotein (LDL) cholesterol (which is calculated as the measurement of cholesterol mass within LDL particles) is made up of small (atherogenic) and large (healthy) particles, there is controversy about total LDL role as a predictor of cardiovascular events. 74 A low TG/HDL ratio reflects 'pattern A' (large LDL particles) and a high TG/HDL ratio reflects 'pattern B' (small LDL particles), the latter being more closely associated with both carbohydrate (particularly refined) intake and cardiovascular disease risk.…”

Section: Discussion Of Key Findingsmentioning

confidence: 99%

“…74 A low TG/HDL ratio reflects 'pattern A' (large LDL particles) and a high TG/HDL ratio reflects 'pattern B' (small LDL particles), the latter being more closely associated with both carbohydrate (particularly refined) intake and cardiovascular disease risk. 90,91 Because of its association with a less atherogenic lipid profile, a TG/HDL ratio close to 1.0 is regarded as predictive of low cardiovascular risk. 92 A higher TG/HDL ratio is also associated with hyperinsulinaemia, 93 which is an independent risk factor for cardiovascular disease.…”

Section: Discussion Of Key Findingsmentioning

confidence: 99%

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A low-carbohydrate survey: Evidence for sustainable metabolic syndrome reversal

Cucuzzella

Tondt

Dockter

et al. 2017

JMH

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Background: Metabolic syndrome has become a significant problem, with the American Diabetes Association estimating the cost of diabetes and pre-diabetes in the United States alone to be $322 billion per year. Numerous clinical trials have demonstrated the efficacy of low-carbohydrate diets in reversing metabolic syndrome and its associated disorders.Aim: This study was designed to examine how voluntary adherents to a low-carbohydrate diet rate its effectiveness and sustainability using an online survey.Setting and methods: The 57-question survey was administered online and shared internationally via social media and ‘low-carb’ communities. Where appropriate, chi-squared tests and paired t-tests were used to analyse the responses.Results: There were 1580 respondents. The majority of respondents had consumed less than 100 g of carbohydrates per day for over a year, typically for reasons of weight loss or disease management. There was a reported decrease in waist circumference and weight with a simultaneous decrease in hunger and increase in energy level. Of those who provided laboratory values, the majority saw improvements in their HbA1c, blood glucose measurements, and lipid panel results. There was a reduction in usage of various medications, and 25% reported medication cost savings, with average monthly savings of $288 for those respondents. In particular, the usage of pain relievers and anti-inflammatories dropped with a simultaneous decreased rating of pain and increase in mobility.Conclusion: We conclude that low-carbohydrate diets are a sustainable method of metabolic syndrome reversal in a community setting.

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Section: Discussion Of Key Findingsmentioning

confidence: 99%

Section: Discussion Of Key Findingsmentioning

confidence: 99%

A low-carbohydrate survey: Evidence for sustainable metabolic syndrome reversal

Cucuzzella

Tondt

Dockter

et al. 2017

JMH

View full text Add to dashboard Cite

show abstract

“…Dyslipidemia in diabetes has been reported to be largely due to insulin resistance [4][5][6][7]. Diabetic dyslipidemia results in the accumulation of excess free fatty acids, which are converted to triglycerides in the liver.…”

Section: Introductionmentioning

confidence: 99%

Suppression of Type-II Diabetes with Dyslipidemia and Nephropathy by Peels of Musa cavendish Fruit

Navghare

Dhawale

2016

Ind J Clin Biochem

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Musa cavendish, peels has local and traditional use to promote wound healing, hyperglycemia, ulceration etc. The present work investigated the lipid lowering; nephroprotective and glucose lowering properties of ethanolic extract of peels of Musa cavendish (EMC) in alloxan-induced diabetic rats. The EMC 250, 500 and 1000 mg/kg/day and the vehicle were administered orally to alloxan-induced diabetic rats (n = 6) for 3 weeks. Changes in plasma glucose, lipid profile along with kidney function before and after treatment with EMC were recorded. The ethanolic extract of peels of Musa cavendish reduced blood glucose, serum triglyceride, cholesterol, LDL cholesterol and creatinine levels and improvement in body weight, liver glycogen, serum HDL cholesterol, serum albumin and total protein level when compared with untreated rats. Musa cavendish has lipid lowering, nephroprotective and antidiabetic property by regulating glucose uptake in the liver and muscles by restoring the intracellular energy balance.

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“…For this reason, both quality and quantity of dietary fat must be considered [9]. In recent years, there has been increasing concern about dietary effects on dyslipidemia, because it can be a major contributor to increase risk of CVD [22]. In the past, reducing saturated fatty acid intake, as a means of lowering LDL-C concentrations, was the main focus of dietary recommendations for CVD prevention and treatment [7].…”

Section: Discussionmentioning

confidence: 99%

Dietary Fat Intake and Its Relationship with Serum Lipid Profiles in Tehranian Adolescents

Mohseni-Takalloo¹,

Mirmiran

Hosseini-Esfahani³

et al. 2014

JFNR

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Dyslipidemia is an important risk factor for cardiovascular disease (CVD) and an important cause of death in adults. Long-term follow-up studies have demonstrated that dietary fat consumption in children and adolescent is one of these risk factors of dyslipidemia in adulthood. The purpose of the current study was to assess the dietary fat intake of Iranian adolescents and their relationship with serum lipid profiles. In this population based cross-sectional study 717 adolescents (391 girls and 326 boys), aged 10 to 19 years, were randomly selected from the fourth phase of Tehran Lipid and Glucose Study (2008)(2009)(2010)(2011). Usual dietary intakes were assessed using valid and reliable food frequency questionnaire and a fasting blood sample was given from all participants to analyze serum lipid profile. Among serum lipid levels, only triglyceride (TG) concentration was higher significantly in boys. In girls, the percent of energy intake from total fat, poly unsaturated fatty acid (PUFA), mono unsaturated fatty acid (MUFA) and trans fatty acids were higher significantly. After adjustment for sex and age, serum levels of TG and HDL-C showed a significant decreasing and increasing trend according to the quartiles of percent of energy intake from PUFA, respectively. No significant difference was observed between other fatty acids and serum lipid profile. In conclusion, although the percent of calorie intake from fat and different types of fatty acids have effect in determining serum lipids levels, but they are not the most important factors for determining the serum lipid profile.

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Metabolic abnormalities: triglyceride and low-density lipoprotein

Cited by 93 publications

References 54 publications

A low-carbohydrate survey: Evidence for sustainable metabolic syndrome reversal

A low-carbohydrate survey: Evidence for sustainable metabolic syndrome reversal

Suppression of Type-II Diabetes with Dyslipidemia and Nephropathy by Peels of Musa cavendish Fruit

Dietary Fat Intake and Its Relationship with Serum Lipid Profiles in Tehranian Adolescents

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