Metabolic abnormalities in adults with cystic fibrosis

Georgiopoulou, Vasiliki V.; Denker, Adam; Bishop, Kathy; Brown, Jason; Hirsh, Benjamin; Wolfenden, Linda L.; Sperling, Laurence

doi:10.1111/j.1440-1843.2010.01771.x

Cited by 34 publications

(36 citation statements)

References 39 publications

(60 reference statements)

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“…This is important because the risk of macrovascular disease has shaped treatment and therapy recommendations for persons with type 1 and type 2 diabetes; many of these recommendations are not relevant in CF and may even be harmful. Cholesterol levels are generally low in CF, but isolated triglyceride elevation is not uncommon . Lipid elevation may be more common after lung transplantation and in older patients with less severe CF mutations.…”

Section: Survival and Prognosismentioning

confidence: 99%

Management of cystic fibrosis-related diabetes in children and adolescents

et al. 2014

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Section: Survival and Prognosismentioning

confidence: 99%

Management of cystic fibrosis-related diabetes in children and adolescents

et al. 2014

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“…70 A study from London reported retinopathy, but also that no macrovascular complications were found. 31 Georgiopoulou et al 71 may have provided much of the explanation. In their study of metabolic aspects of CF, they noted that total and low-density lipoprotein cholesterol were low (total cholesterol 3.5 mmol/l, low-density lipoprotein 1.27 mmol/l), but that high-density lipoprotein cholesterol was near normal.…”

Section: Complicationsmentioning

confidence: 99%

Screening for cystic fibrosis-related diabetes: a systematic review.

Waugh

Royle²,

Craigie³

et al. 2012

Health Technol Assess

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How to obtain copies of this and other HTA programme reports An electronic version of this title, in Adobe Acrobat format, is available for downloading free of charge for personal use from the HTA website (www.hta.ac.uk). A fully searchable DVD is also available (see below).Printed copies of HTA journal series issues cost £20 each (post and packing free in the UK) to both public and private sector purchasers from our despatch agents.Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per issue and for the rest of the world £3 per issue. How to order:-fax (with credit card details) -post (with credit card details or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you to either print out your order or download a blank order form. Contact details are as follows:Synergie UK (HTA Department) Digital House, The Loddon Centre Wade Road Basingstoke Hants RG24 8QW Email: orders@hta.ac.uk Tel: 0845 812 4000 -ask for 'HTA Payment Services' (out-of-hours answer-phone service) Fax: 0845 812 4001 -put 'HTA Order' on the fax header Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to University of Southampton and drawn on a bank with a UK address.Paying by credit card You can order using your credit card by phone, fax or post. SubscriptionsNHS libraries can subscribe free of charge. Public libraries can subscribe at a reduced cost of £100 for each volume (normally comprising 40-50 titles). The commercial subscription rate is £400 per volume (addresses within the UK) and £600 per volume (addresses outside the UK). Please see our website for details. Subscriptions can be purchased only for the current or forthcoming volume.How do I get a copy of HTA on DVD?Please use the form on the HTA website (www.hta.ac.uk/htacd/index.shtml). HTA on DVD is currently free of charge worldwide.The website also provides information about the HTA programme and lists the membership of the various committees. HTA NIHR Health Technology Assessment programmeThe Health Technology Assessment (HTA) programme, part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the effectiveness, costs and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined as all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care. The research findings from the HTA programme directly influence decision-making bodies such as the National Institute for Health and Clinical Excellence (NICE) and the National Screening Committee (NSC). HTA findings also help to improve the quality of clinical practice in the NHS indirectly in that they form a key component of the 'National Knowledge Service' . The HTA programme is needs led in that it fills gaps in the evidence needed by the NHS. There are three routes to the start of projects...

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“…Recent studies have demonstrated the application of lipidomics in studies investigating diabetes, cystic fibrosis, respiratory diseases and neurodegenerative diseases. These studies have clearly indicated the potential usefulness of lipidomics both to generate biomarkers of disease and to probe signalling and metabolic processes [ 5 – 9 ].…”

Section: Introductionmentioning

confidence: 99%

Modulation of the lipidomic profile due to a lipid challenge and fitness level: a postprandial study

et al. 2015

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BackgroundThe lipid composition of plasma is known to vary due to both phenotypic factors such as age, gender and BMI as well as with various diseases including cancer and neurological disorders. However, there is little investigation into the variation in the lipidome due to exercise and/ or metabolic challenges. The objectives of this present study were (i) To identify the glycerophospholipid, sphingolipids and ceramide changes in response to an oral lipid tolerance test (OLTT) in healthy adults and (ii) To identify the effect of aerobic fitness level on lipidomic profiles.Methods214 healthy adults aged 18–60 years were recruited as part of a metabolic challenge study. A sub-group of 40 volunteers were selected for lipidomic analysis based on their aerobic fitness level. Ceramides, glycerophospholipids and sphingomyelins were quantified in baseline fasting plasma samples as well as at 60, 120, 180, 240 and 300 min following a lipid challenge using high-throughput flow injection ESI-MS/MS.ResultsMixed model repeated measures analysis identified lipids which were significantly changing over the time course of the lipid challenge. Included in these lipids were lysophosphoethanolamines (LPE), phosphoethanolamines (PE), phosphoglycerides (PG) and ceramides (Cer). Five lipids (LPE a C18:2, LPE a C18:1, PE aa C36:2, PE aa C36:3 and N-C16:1-Cer) had a fold change > 1.5 at 120 min following the challenge and these lipids remained elevated. Furthermore, three of these lipids (LPE a C18:2, PE aa C36:2 and PE aa C36:3) were predictive of fasting and peak plasma TAG concentrations following the OLTT. Further analysis revealed that fitness level has a significant impact on the response to the OLTT: in particular significant differences between fitness groups were observed for phosphatidylcholines (PC), sphingomyelins (SM) and ceramides.ConclusionThis study identified specific lipids which were modulated by an acute lipid challenge. Furthermore, it identified a series of lipids which were modulated by fitness level. Future lipidomic studies should take into account environmental factors such as diet and fitness level during biomarker discovery work.Trial registrationData, clinicaltrials.gov, NCT01172951Electronic supplementary materialThe online version of this article (doi:10.1186/s12944-015-0062-x) contains supplementary material, which is available to authorized users.

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Metabolic abnormalities in adults with cystic fibrosis

Abstract: Abnormalities of glucose metabolism are highly prevalent in CF patients, and are accompanied by hypertriglyceridaemia in the 30-39 years age group. Prospective studies are required to confirm lipid abnormalities and investigate possible cardiovascular complications in patients with CF.

Cited by 34 publications

References 39 publications

Management of cystic fibrosis-related diabetes in children and adolescents

Management of cystic fibrosis-related diabetes in children and adolescents

Screening for cystic fibrosis-related diabetes: a systematic review.

Modulation of the lipidomic profile due to a lipid challenge and fitness level: a postprandial study

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