Metabolic abnormalities associated with skeletal myopathy in severe anorexia nervosa

McLoughlin, Declan M.; Wassif, Wassif S.; Morton, John; Spargo, E; Peters, Tim J.; Russell, G. F. M.

doi:10.1016/s0899-9007(99)00286-5

Cited by 36 publications

(26 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is in contrast to the weak negative linear relationship between some cortisol measures and lean body mass. Despite the reported lack of specific symptoms and signs of hypercortisolemia, AN has been reported to be associated with a metabolic myopathy similar to steroid myopathy (38), and we found that some measures of hypercortisolemia are associated with decreased lean body mass. We observe that cortisol measures are negatively associated with BMD across the weight spectrum, which suggests that relative hypercortisolemia may contribute to bone loss in the setting of caloric restriction and excess.…”

Section: Discussioncontrasting

confidence: 55%

Cortisol Measures Across the Weight Spectrum

Schorr¹,

Lawson²,

Dichtel³

et al. 2015

The Journal of Clinical Endocrinology & Metabolism

View full text Add to dashboard Cite

Cortisol measures are lowest in overweight-class I obese women-lower than in lean women. With more significant obesity, cortisol levels increase, although not to as high as in AN. Therefore, extreme underweight and overweight states may activate the HPA axis, and hypercortisolemia may contribute to increased adiposity in the setting of caloric excess. Hypercortisolemia may also contribute to decreased BMD and muscle wasting in the setting of both caloric restriction and excess.

show abstract

Section: Discussioncontrasting

confidence: 55%

Cortisol Measures Across the Weight Spectrum

Schorr¹,

Lawson²,

Dichtel³

et al. 2015

The Journal of Clinical Endocrinology & Metabolism

View full text Add to dashboard Cite

show abstract

“…We also reconsidered previous preliminary observations 15,18 and addressed the issue of concurrent presence of different enzyme abnormalities. First of all, it is of note that in the A-NERV group transaminases correlated directly with LDH, GGT, and inversely with CHE.…”

Section: Resultsmentioning

confidence: 98%

Cholinesterase and other serum liver enzymes in underweight outpatients with eating disorders

Montagnese¹,

Scalfi²,

Signorini³

et al. 2007

Intl J Eating Disorders

View full text Add to dashboard Cite

show abstract

“…In anorectic humans, loss of muscle bulk and muscle fiber atrophy are the most prominent effects of self-induced prolonged fasting (Lindboe et al, 1982). McLoughlin et al (McLoughlin et al, 2000) also reported changes in blood plasma parameters in anorectic patients, including elevated levels of aspartate aminotransferase (AST), an enzyme associated with the transfer of nitrogen-containing groups between amino acids. Changes in the blood chemistry of sled dogs competing in a long distance race include significant increases of AST and creatine kinase (CK), indicating severe muscle breakdown .…”

Section: Introductionmentioning

confidence: 99%

Muscle plasticity of Inuit sled dogs in Greenland

Gerth

Sum

Jackson

et al. 2009

Journal of Experimental Biology

View full text Add to dashboard Cite

SUMMARYThis study examined flexible adjustments of skeletal muscle size, fiber structure, and capillarization in Inuit sled dogs responding to seasonal changes in temperature, exercise and food supply. Inuit dogs pull sleds in winter and are fed regularly throughout this working season. In summer, they remain chained to rocks without exercise, receiving food intermittently and often fasting for several days. We studied two dog teams in Northern Greenland (Qaanaaq) where dogs are still draught animals vital to Inuit hunters, and one dog team in Western Greenland (Qeqertarsuaq) where this traditional role has been lost. Northern Greenland dogs receive more and higher quality food than those in Western Greenland. We used ultrasonography for repeated muscle size measurements on the same individuals, and transmission electron microscopy on micro-biopsies for summer-winter comparisons of muscle histology, also within individuals. At both study sites, dogs' muscles were significantly thinner in summer than in winter -atrophy attributable to reduced fiber diameter. Sarcomeres from West Greenland dogs showed serious myofilament depletion and expansion of the sarcoplasmatic space between myofibrils during summer. At both study sites, summer samples showed fewer interfibrillar and subsarcolemmal mitochondria, and fewer lipid droplets between myofibrils, than did winter samples. In summer, capillary density was higher and inter-capillary distance smaller than in winter, but the capillaryto-fiber-ratio and number of capillaries associated with single myofibers were constant. Increased capillary density was probably a by-product of differential tissue responses to condition changes rather than a functional adaptation, because thinning of muscle fibers in summer was not accompanied by reduction in the capillary network. Thus, skeletal muscle of Inuit dogs responds flexibly to changes in functional demands. This flexibility is based on differential changes in functional components: mitochondrial numbers, lipid droplet size, and the number of contractile filaments all increase with increasing workload and food supply while the capillary network remains unchanged.

show abstract

Metabolic abnormalities associated with skeletal myopathy in severe anorexia nervosa

Cited by 36 publications

References 25 publications

Cortisol Measures Across the Weight Spectrum

Cortisol Measures Across the Weight Spectrum

Cholinesterase and other serum liver enzymes in underweight outpatients with eating disorders

Muscle plasticity of Inuit sled dogs in Greenland

Contact Info

Product

Resources

About