Metaanalysis of Survival, Complications, and Imaging Response following Chemotherapy-based Transarterial Therapy in Patients with Unresectable Intrahepatic Cholangiocarcinoma

Ray, Charles E.; Edwards, Anthony; Smith, Mitchell T.; Leong, Stephen; Kondo, Kimi L.; Gipson, Matthew G.; Rochon, Paul J.; Gupta, Rajan; Messersmith, Wells A.; Purcell, Thomas J.; Durham, Janette D.

doi:10.1016/j.jvir.2013.03.019

Cited by 84 publications

(57 citation statements)

References 27 publications

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“…On the other hand, recurrence in peripheral ICC is almost always intrahepatic. Therefore, perioperative chemotherapy via the hepatic artery is also an option towards improving survival (25). In addition, considering the recurrence pattern and the relatively low rate of ly and pn in peripheral ICC, liver transplantation with perioperative chemotherapy could be a feasible choice (26,27).…”

Section: Discussionmentioning

confidence: 99%

Clinical Significances of Preoperative Classification of Intrahepatic Cholangiocarcinoma: Different Characteristics of Perihilar vs. Peripheral ICC

Yamashita

Wang

Kurihara

et al. 2016

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Abstract. Background: The aim of this study was to evaluate the clinical significance of preoperative classification of intrahepatic cholangiocarcinoma (ICC) into perihilar and peripheral types using dynamic computed tomography (CT). Patients and MethodsEven though intrahepatic cholangiocarcinoma (ICC) is a relatively rare disease, it is the second most common primary liver malignant tumor after hepatocellular carcinoma (HCC), and has a relatively highly prevalence in Asia and the U.S.A., with over 1/100,000 population ratio (1). In addition, the incidence of ICC has rapidly increased by 165% in the last 30 years in the U.S.A., and surgical resection remains the only treatment available with curative intent (2). However, surgical results for ICC remain unsatisfactory with a five-year survival rate of 58%, even in R0 resected cases (3). Lymph node metastasis has been reported to be the most significant poor prognostic factor for ICC, and extended lymphadenectomy does not have a survival impact (3-5). While lymphatic invasion is the major mode of cancer spreading for ICC (6), intrahepatic metastasis caused by venous spread is another important mode of spreading (4, 5).ICCs are composed of heterogenous carcinomas arising from different anatomical liver sites. ICC arises from the epithelial cells of the biliary tree, from either intrahepatic large bile ducts or smaller bile ducts, such as the septal and interlobular ducts. Ebata et al. clearly defined as perihilar cholangiocarcinoma, a tumor involving the hilar bile duct with a liver mass (7). We proposed the classification of ICC based on the pathological findings in perihilar large duct type and peripheral small duct type subtypes (8, 9). Perihilar ICC arises from the peribiliary gland, and peripheral ICC from the canals of Hering (9); the two subtypes have different molecular and clinicopathological characteristics and patient prognoses (8, 9). However, pathological classification currently contributes only whether or not to plan adjuvant chemotherapy. Therefore, it is important to construct a preoperative classification that can be used to modify surgical plans and so on to improve patients' prognosis for ICC. 6563

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Section: Discussionmentioning

confidence: 99%

Clinical Significances of Preoperative Classification of Intrahepatic Cholangiocarcinoma: Different Characteristics of Perihilar vs. Peripheral ICC

Yamashita

Wang

Kurihara

et al. 2016

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“…However, combined chemotherapy using S‐1 did not give a marked survival benefit, with median overall survival found to be 8.7–11.6 months . Patients with unresectable ICC have a limited benefit from systemic standard chemotherapy, with a meta‐analysis showing a survival benefit of only a few months using chemotherapy‐based transarterial therapy …”

Section: Discussionmentioning

confidence: 99%

Proton beam therapy for unresectable intrahepatic cholangiocarcinoma

Ohkawa

Mizumoto

Ishikawa

et al. 2015

J of Gastro and Hepatol

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“…A meta-analysis in 2013 (16 studies, n = 542) reported on the imaging responses, complications and OS following hepatic artery-based therapies (cTACE, DEB-TACE, DSM-TACE and HAI) for unresectable intrahepatic cholangiocarcinoma [57]. Weighted median OS from diagnosis and from procedure was 15.7 and 13.4 months, respectively.…”

Section: Vascular Therapiesmentioning

confidence: 99%

Locoregional therapies in cholangiocarcinoma

et al. 2017

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Cholangiocarcinoma is a rare and aggressive malignancy of the biliary tract. Complete surgical resection can be curative, but the majority of patients are diagnosed with advanced disease and usually die within a year of diagnosis. Most deaths are attributable to local disease progression rather than distant metastases, supporting the use of locoregional therapies. There is evidence that locoregional therapies can provide local tumor control resulting in increased survival while avoiding some of the side effects of systemic treatments, increasing potential treatment options for patients who may be unsuitable for systemic palliative treatments. This review considers the evidence for locoregional therapies in cholangiocarcinoma, which can be classified into endoscopic, vascular, percutaneous and radiation oncological therapies. Current guidelines do not recommend the routine use of locoregional therapies due to a lack of prospective data, but the results of ongoing trials are likely to increase the evidence base and impact on clinical practice.

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Metaanalysis of Survival, Complications, and Imaging Response following Chemotherapy-based Transarterial Therapy in Patients with Unresectable Intrahepatic Cholangiocarcinoma

Cited by 84 publications

References 27 publications

Clinical Significances of Preoperative Classification of Intrahepatic Cholangiocarcinoma: Different Characteristics of Perihilar vs. Peripheral ICC

Clinical Significances of Preoperative Classification of Intrahepatic Cholangiocarcinoma: Different Characteristics of Perihilar vs. Peripheral ICC

Proton beam therapy for unresectable intrahepatic cholangiocarcinoma

Locoregional therapies in cholangiocarcinoma

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