2019
DOI: 10.1002/biot.201800445
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Meta‐Omics‐ and Metabolic Modeling‐Assisted Deciphering of Human Microbiota Metabolism

Abstract: The human microbiota is a complex community of commensal, symbiotic, and pathogenic microbes that play a crucial role in maintaining the homeostasis of human health. Such a homeostasis is maintained through the collective functioning of enzymatic genes responsible for the production of metabolites, enabling the interaction and signaling within microbiota as well as between microbes and the human host. Understanding microbial genes, their associated chemistries and functions would be valuable for engineering sy… Show more

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Cited by 10 publications
(2 citation statements)
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“…In recent years, the development of metabolomic approaches (mostly using proton nuclear magnetic resonance and mass spectrometry) has contributed to this field, attempting to define a human “fecal metabolome,” comprised of small molecules from digested food, mainly metabolites (and residues from metabolites) of human origin, and more importantly from the effects of microbiota acting on human, food, or microbial organic substances, or resulting from bacterial degradation (Matsumoto et al, 2012; Xu et al, 2015; Milshteyn et al, 2018). Multiomics approaches in combination with metabolic modeling will soon contribute to a more complete view of chemical flows in the intestinal microbiota (Sieow et al, 2019).…”
Section: The Intestinal Chemosphere: Molecular Ecologymentioning
confidence: 99%
“…In recent years, the development of metabolomic approaches (mostly using proton nuclear magnetic resonance and mass spectrometry) has contributed to this field, attempting to define a human “fecal metabolome,” comprised of small molecules from digested food, mainly metabolites (and residues from metabolites) of human origin, and more importantly from the effects of microbiota acting on human, food, or microbial organic substances, or resulting from bacterial degradation (Matsumoto et al, 2012; Xu et al, 2015; Milshteyn et al, 2018). Multiomics approaches in combination with metabolic modeling will soon contribute to a more complete view of chemical flows in the intestinal microbiota (Sieow et al, 2019).…”
Section: The Intestinal Chemosphere: Molecular Ecologymentioning
confidence: 99%
“…In addition, another fascinating discovery is that changes in energy metabolism are inseparable from changes in gut microbiota, including citric acid, glutaric acid, and malonic acid (Cani et al, 2019). The changes of co-metabolites in the body reflect changes in the gut microbiota (Sieow et al, 2019). It also can be said that the metabolic phenotype is closely related to the gut microbiota.…”
Section: Discussionmentioning
confidence: 99%