Meta‐inflammaging at the crossroad of geroscience

Abstract

Geroscience posits that selected fundamental biological processes are the foundation of age-related chronic diseases and are responsible for the decline in physical and mental function in old age. Late-life chronic low-grade inflammation ("inflammaging") and altered signal transduction pathways in metabolism have been identified as two of the key themes in the aging process. Age-related changes in the immune and metabolic responses are also recognized as playing a critical pathogenic role in most common chronic medical conditions that plague the elderly. Emerging investigations emphasize the interconnectedness of the immune and metabolic responses in aging, an area of gerontological research that can be termed "meta-inflammaging." K E Y

MSCs and Inflammatory Cells Crosstalk in Regenerative Medicine: Concerted Actions for Optimized Resolution Driven by Energy Metabolism

“…Based on relevant selection criteria and optimized production process, allogenic MSCs position as multimodal tools able to take in charge biological functions interfacing with all organs. Allogenic MSCs therapy by targeting inflammaging and metabolism-aging thus appears in line with geroscience perspectives (216) and is a major challenge to address for the upcoming regenerative and rejuvenative medicine strategies.…”

A research agenda for ageing in China in the 21st century (2nd edition): Focusing on basic and translational research, long-term care, policy and social networks

“…In addition, a decline in immune surveillance hampers the elimination of premalignant cells, leading to cancer development. Older adults also manifest a chronic low-grade inflammatory phenotype (CLIP), a manifestation of the inflammageing concept, that likely results from uncompensated inhibitory immune regulation and/or an inability to eliminate senescent cells ( Chen and Yung, 2019 ; Chen et al, 2019b ). As such, immune dysregulation is a general feature of ageing.…”

Neuroinflammation in Alzheimer’s Disease

“…Aging is characterized by dysregulated immune [ 1 ] and metabolic homeostasis [ 2 , 3 ] where there is chronic sterile low-grade inflammation or inflammaging [ 4 ] that involves cellular senescence [ 5 , 6 ], immunosenescence [ 7 , 8 , 9 , 10 ], mitochondrial dysfunction [ 11 , 12 ], defective autophagy [ 13 , 14 ] and mitophagy [ 15 , 16 ], dysregulation of the ubiquitin–proteasome system [ 17 , 18 ], activation of the DNA damage response [ 19 , 20 ], meta-inflammation or metaflammation from chronic overnutrition or obesity [ 21 , 22 ], and gut microbiota dysbiosis [ 5 , 23 , 24 , 25 ]. These are reflected by changes in circulating immune markers including C-reactive protein (CRP) [ 26 ], interleukin-6 (IL-6) [ 27 ], tumor necrosis factor alpha (TNF-α) [ 28 ] and its soluble receptors (tumor necrosis factor receptor I (TNFR-I) and tumor necrosis factor receptor II (TNFR-II)) [ 28 ], vascular cell adhesion molecule I (VCAM-I) [ 29 ], d-dimer [ 30 ], and sirtuin signaling [ 31 , 32 ].…”