Meta-analytic method reveal a significant association of theBDNF Val66Met variant with smoking persistence based on a large samples

Abstract

Although numerous genetic studies have reported the link between Val66Met in BDNF gene with smoking, the findings remain controversial, mainly due to small-to-moderate sample sizes. The main aim of current investigation is to explore whether the variant of Val66Met has any genetic functions in the progress of smoking persistence. The Val-based dominant genetic model considering Val/* (namely, Val/Val + Val/Met) and Met/Met as two genotypes with comparison of the frequency of each genotype in current smokers and never smokers. There were seven genetic association articles including eight independent datasets with 10,160 participants were chosen in current meta-analytic investigation. In light of the potent effects of ethnicity on homogeneity across studies, we carried out separated meta-analyses according to the ancestry origin by using the wide-used tool of Comprehensive Meta-analysis software (V 2.0). Our meta-analyses results indicated that the Val66Met polymorphism was significantly linked with smoking persistence based on either all the chosen samples (N = 10,160; Random and fixed models: pooled OR = 1.23; 95% CI = 1.03-1.46; P value = 0.012) or Asian samples (N = 2,095; Fixed model: pooled OR = 1.25; 95% CI = 1.01-1.54; P value = 0.044; Random model: pooled OR = 1.25; 95% CI = 1.001-1.56; P value = 0.049). No significant clue of bias in publications or heterogeneity across studies was detected. Thus, we conclude that the Val66Met (rs6265) variant conveys genetic susceptibility to maintaining smoking, and smokers who carry Val/* genotypes have a higher possibility of maintaining smoking than those having Met/Met genotype.

The association between smoking cessation and lifestyle/genetic variant rs6265 among the adult population in Taiwan

“…Additionally, a previous meta-analyses showed that the Val66Met variant moderately affects smoking persistence in a large-scale sample, and the possibility of continued smoking was 23% greater for individuals with the Val/* genotype compared to those with the Met/Met genotype, indicating that the dopamine-relevant functions of the Val66Met variant may be involved in the biological process associated with smoking persistence 17 . An earlier study reported the association between BDNF Val66Met and SI in a Finnish population 18 .…”

“…Previous meta-analyses showed that the Val66Met variant has a moderate effect on smoking persistence in a large-scale sample. When compared among individuals with the Met/Met genotype, individuals with the Val/* genotype had a 23% greater possibility of maintaining smoking 17 . Previous research conducted in the Finnish population found a robust and independent association between BDNF Val66Met and smoking initiation (SI), with results suggesting that this association is not influenced by depression 18 .…”