Meta‐analytic evidence for downregulation of the amygdala during working memory maintenance

Voogd, Lycia D. de; Hermans, Erno J.

doi:10.1002/hbm.25828

Cited by 11 publications

(7 citation statements)

References 66 publications

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“…Second, dlPFC and dACC were found to have densely reciprocal connections with the amygdala 63 . The feedback inhibition from dlPFC and dACC to amygdala align with earlier findings, as these regions are thought to downregulate the amygdala not only during explicit emotion regulation but also during cognitively demanding tasks 64,65 . The context-dependent interaction of amygdala with prefrontal regions in video-watching behaviors might arise from the differentiated projections from the positive- and negative-encoding neurons in amygdala 66 , but circuitry level evidence is required to test this conjecture.…”

Section: Discussionsupporting

confidence: 87%

Prefrontal suppression in short-video viewing: unraveling the neural correlates of self-control

Su,

Teng,

Zhou

et al. 2023

Preprint

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The recent surge in short-video application usage has raised concerns about potential mental health risks. Using a novel video-watching task, we investigated the neuropsychological mechanisms underlying self-control during short-video viewing from a dual-system perspective. Results revealed watching preferred videos significantly activated the amygdala (System I) and deactivated the control regions (System II), with individuals with lower trait self-control being suppressed more. Dynamic causal modelling revealed the amygdala inhibited control regions during preferred viewing, while control regions downregulated the amygdala during less-preferred viewing. The control regions also demonstrated enhanced activation during cognitive control and inner-state monitoring tasks, with the latter correlating with trait self-control. These findings suggest preference-based video-watching suppresses prefrontal areas that represent rules and support self-awareness, enabling bottom-up limbic processes to dominate attention. This study provides insights into the neuropsychological impacts of short-video applications use, informing policies and interventions to promote healthier technology use and mitigate potential adverse effects.

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Section: Discussionsupporting

confidence: 87%

Prefrontal suppression in short-video viewing: unraveling the neural correlates of self-control

Su,

Teng,

Zhou

et al. 2023

Preprint

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“…On the one hand, we suggest that the current results may be a consequence of competition between salience/defensive neural networks and central-executive networks. In our study, adaptive WMT was a cognitively demanding activity, and performing this task resulted in increased activation of the central-executive network (de Voogd & Hermans, 2022). Correspondingly, the activation of salience/defensive neural networks involved in the amygdala is diminished, which may lead to a general improvement in ER.…”

Section: Discussionmentioning

confidence: 82%

Effects of working memory training on different goals of cognitive reappraisal.

Long¹,

Zhou²,

Zhang³

et al. 2024

Emotion

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Working memory training (WMT) has shown potential benefits in emotion regulation (ER), mainly in terms of improved ability to downregulate negative emotions in cognitive reappraisal. However, the goal of cognitive reappraisal can be not only to reduce negative emotion but also to increase negative emotion. It is not clear what effect WMT has on the upregulation of negative emotion. In the current study, we conducted a 20-day WMT with participants to explore the effects of training on the down- and upregulation of negative emotion and followed participants for 3 months after training to examine the persistent effects of training. Our results suggest that participants in the training group improved their ability to regulate negative emotions in both the down- and upregulation conditions. Notably, benefits from training were also observed in the look negative condition, suggesting that WMT may elicit general cognitive enhancement that is broadly transferable to any kind of negative situation to help individuals regulate the effects of negative emotions. In addition, our study also showed that the improvement in negative ER by training could last even over 3 months.

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“…An increase in DLPFC activity has been shown to facilitate emotion regulation and improve cognitive control (Chen, Oei et al 2023), and impaired emotional regulation due to DLPFC dysfunction is closely related to depression, in which the complex interaction between cognition and emotion is significantly disrupted (Salehinejad, Ghanavai et al 2017). Previous studies have repeatedly shown a negative correlation between DLPFC and AMY (Davidson and Irwin 1999, Mayberg, Liotti et al 1999, Damasio, Grabowski et al 2000, demonstrating top-down control of emotion through increased DLPFC recruitment (Bishop 2008, Iordan, Dolcos et al 2013) to down-regulate activity in AMY (Loos, Schicktanz et al 2020, de Voogd andHermans 2022).…”

Section: Discussionmentioning

confidence: 99%

Increased Resting Brain Entropy in Mild to Moderate Depression was Decreased by Nonpharmacological Treatment

Song,

Wang,

Wang

2024

Preprint

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Entropy indicates systematic irregularity and information capacity. Recent years have seen increasing interest in assessing regional brain entropy (BEN) using fMRI in healthy controls (HCs) and patients with various brain diseases. Depression and anti-depressant related BEN alterations have been reported in several initial studies. Re-examining these effects using independent cohort is crucial given the high complexity of depression. In this study, we used open data from OpenNeuro from 46 mild to moderate depression patients and 20 HCs to examine regional BEN and its changes due to nonpharmacological treatment (14 patients underwent nonpharmacological treatment). Functional connectivity (FC) analysis was performed to assess the inter-regional relationship between the brain regions showing BEN effects and the rest of the brain. Compared to HCs, depression patients showed increased BEN in left DLPFC, precuneus, and limbic system, including the amygdala, parahippocampal gyrus and hippocampus. Increased BEN in DLPFC, precuneus, and amygdala were suppressed by a nonpharmacological treatment in each individual patient. HCs had positive FC between left and right DLPFC and negative FC between left DLPFC and limbic areas, while patients had abnormally lower or negative FC between left and right DLPFC and positive FC between left DLPFC and the limbic area. These left DLPFC seeded FC changes in patients were reverted after nonpharmacological treatment. The findings highlight the left DLPFC and limbic system in depression and the treatment effects, and patients with depression exhibit significant emotion dysregulation, which is effectively addressed by nonpharmacological treatment targeting the top-down emotion regulation functions mediated by the DLPFC-limbic system. Different from existing literature, these results suggest the entropy/irregularity of DLPFC and limbic system as a potential mechanism underlying depression and suggest BEN in left DLPFC as a potential personalized marker for assessing depression and the corresponding nonpharmacological treatment effects.

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Meta‐analytic evidence for downregulation of the amygdala during working memory maintenance

Cited by 11 publications

References 66 publications

Prefrontal suppression in short-video viewing: unraveling the neural correlates of self-control

Prefrontal suppression in short-video viewing: unraveling the neural correlates of self-control

Effects of working memory training on different goals of cognitive reappraisal.

Increased Resting Brain Entropy in Mild to Moderate Depression was Decreased by Nonpharmacological Treatment

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