Meta-analysis: vitamin D and non-alcoholic fatty liver disease

Eliades, Myrto; Spyrou, Elias; Agrawal, Neha; Lazo, Mariana; Brancati, F. L.; Potter, James J.; Koteish, Ayman; Clark, Jeanne M.; Güallar, Eliseo; Hernáez, Rubén

doi:10.1111/apt.12377

Cited by 236 publications

(197 citation statements)

References 56 publications

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“…Nevertheless, additional analysis performed in our study showed lower concentration level of the fibroblast growth factor 19 (FGF19) in patients with hypovitaminosis D. Fibroblast growth factor 19 (FGF19) is a hormone released from the small intestine; recently, it has emerged as an endocrine regulator of glucose and lipid metabolism. The results of the presented study, although not statistically significant, need particular attention, since a decrease in fasting FGF19 is an independent risk factor for the development of NAFLD in obese adolescents [23,24,25]. Its relationship to vitamin D deficiency needs further investigation.…”

Section: Meanmentioning

confidence: 64%

The potential impact of the hypovitaminosis D on metabolic complications in obese adolescents – Preliminary results

Wójcik

Januś

Kalicka-Kasperczyk

et al. 2017

Ann Agric Environ Med.

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Introduction and objective. Vitamin D deficiency is common in obesity; however, its contribution in the development of metabolic complications remains uncertain. The aim of the study was to examine the relationships between vitamin D status and metabolic complications. Materials and method. The results of blood pressure measurements, biochemical tests and ultrasound of the liver were compared in both groups. The study was conducted at the Children's University Hospital in Krakow, Poland. 30 obese adolescents (mean 13.23y.o.); 18 with 25OHD levels <20ng/mL, 12 with 25OHD>20 ng/mL. Results. The vitamin D deficient group presented with significantly higher values of the diastolic blood pressure (125.9vs.115mmHg), uric acid level (384.7vs.301.5umol/L) and lower phosphorus level (1.4vs.1.65mmol/L), higher prevalence of arterial hypertension (44vs.8.3%), and liver steatosis (25vs.8.3%); lower, but not significantly, levels of fibroblast growth factor 23 and fibroblast growth factor 19. Conclusions. Hypovitaminosis D in obese adolescents is associated with higher prevalence of arterial hypertension, liver steatosis, elevated serum uric acid and low phosphorus levels. The potential contribution of the fibroblast growth factor 23 and fibroblast growth factor 19 in these complications development needs further investigation.

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Section: Meanmentioning

confidence: 64%

The potential impact of the hypovitaminosis D on metabolic complications in obese adolescents – Preliminary results

Wójcik

Januś

Kalicka-Kasperczyk

et al. 2017

Ann Agric Environ Med.

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“…25 No 2: 175-181 peroxisome proliferator-activated receptor gamma (PPAR-γ) [12,13]. Although not all [14,15], many observational studies report associations between vitamin D deficiency and hepatic steatosis [12,16], the aggregate effect of which has been illustrated in a meta-analysis [17] confirming the presence of decreased serum 25-hydroxyvitamin D concentrations in such patients. Specifically, they were 26% more likely than healthy controls to be vitamin D deficient.…”

Section: Introductionmentioning

confidence: 99%

Effect of Short-Term Vitamin D Correction on Hepatic Steatosis as Quantified by Controlled Attenuation Parameter (CAP)

Papapostoli

Lammert

Stokes

2016

JGLD

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Introduction: Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in Western countries. A meta-analysis has confirmed decreased serum 25-hydroxyvitamin D levels in NAFLD patients. This intervention study investigates whether vitamin D correction ameliorates hepatic steatosis. Methods: We prospectively recruited 40 patients from an outpatient liver clinic with vitamin D deficiency (serum 25-hydroxyvitamin D < 20 ng/ml). Controlled attenuation parameter (CAP) during transient elastography quantified hepatic steatosis. Patients with significant liver fat accumulation were included, which was defined by a CAP value ≥ 280 dB/m. Patients received 20,000 IU vitamin D/week for six months, while vitamin D status, liver function tests (LFTs), CAP and body composition were monitored. Results: The cohort comprised 47.5% women (age 54.9 ± 12.1 years; BMI 29.5 ± 3.0 kg/m2). Mean serum vitamin D level was 11.8 ± 4.8 ng/ml. CAP decreased significantly from baseline (330 ± 32 vs. 307 ± 41 dB/m) during supplementation (P = 0.007). A mean CAP reduction relative to baseline was demonstrated at four weeks and three and six months: -5.3 ± 13.8%; -6.0 ± 14.6% and -6.4 ± 13.0%, respectively. During these time points, restoration of serum vitamin D levels was observed (34.6 ± 12.9, 36.3 ± 10.2, 34.8 ± 9.8 ng/ml; P < 0.0001). Liver function tests and body composition remained unchanged. Conclusions: Hepatic steatosis, as assessed by CAP, significantly improves after only 4 weeks of vitamin D correction. Hepatic steatosis is a dynamic process, that can be monitored in the short-term using such non-invasive methods. Abbreviations: ALT: alanine aminotransferase; ANOVA: analysis of variance; AP: alkaline phosphatase; AST: aspartate aminotransferase; CAP: controlled attenuation parameter; CRP: C-reactive protein; FFA: free fatty acids; γ-GT: gamma-glutamyl transpeptidase; ITT: intention-to-treat; LFT: liver function test; LSM: liver stiffness measurement; NAFLD: non-alcoholic fatty liver disease; PPAR-γ: peroxisome proliferator-activated receptor gamma; PP: per protocol; PTH: parathyroid hormone; VDR: vitamin D receptor

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“…The prevalence of NAFLD in obese children is estimated to be between 36 and 44%, regardless of the method used to diagnose the disease (4,5). It is worth noting that VD deficiency is more common in obese subjects than in normal-weight subjects (6). Furthermore, a recent meta-analysis has shown that NAFLD patients have decreased serum VD levels (7).…”

Section: Introductionmentioning

confidence: 99%

Vitamin D levels and liver histological alterations in children with nonalcoholic fatty liver disease

Nobili

Giorgio

Liccardo

et al. 2014

European Journal of Endocrinology

103

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Objective: To investigate the association between plasma vitamin D (VD) levels and histological liver damage in children with nonalcoholic fatty liver disease (NAFLD). Subjects and methods: In this cross-sectional study, carried out in a tertiary care center for obesity, 73 consecutive overweight and obese children with persistently elevated serum aminotransferase levels and diffusely hyperechogenic liver on ultrasonography were selected for liver biopsy. Nonalcoholic steatohepatitis (NASH) and fibrosis were histologically diagnosed using NAFLD Clinical Research Network (CRN) criteria. The plasma levels of 25-OH-VD were measured by HPLC. Bone mineral density (BMD) of lumbar spine was evaluated by dual-energy X-ray absorptiometry. Multiple linear regression analysis was used to evaluate the association between 25-OH-VD levels and the predictors of interest after correction for age, gender, waist circumference, BMI, and other potential confounders. Results: The children (64% males) were aged 8-18 years, and their median BMI was 2.45 SDS. Both parathyroid hormone levels and BMD were within the normal range. All cases of fibrosis were detected in children with NASH. On multivariable linear regression with correction for age, gender, and BMI, 25-OH-VD levels were found to be 9 (95% CI 12-6) ng/ml lower in children with NASH than in those without NASH (P!0.001) and 9 (12-6) ng/ml lower in children with stage 1 fibrosis than in those with stage 0 fibrosis and 9 (13-6) ng/ml lower in children with stage 2 than in those with stage 0 fibrosis (P!0.001 for both). Conclusion: VD levels are inversely associated with NASH and fibrosis in children with NAFLD.

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Meta-analysis: vitamin D and non-alcoholic fatty liver disease

Cited by 236 publications

References 56 publications

The potential impact of the hypovitaminosis D on metabolic complications in obese adolescents – Preliminary results

The potential impact of the hypovitaminosis D on metabolic complications in obese adolescents – Preliminary results

Effect of Short-Term Vitamin D Correction on Hepatic Steatosis as Quantified by Controlled Attenuation Parameter (CAP)

Vitamin D levels and liver histological alterations in children with nonalcoholic fatty liver disease

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