Meta-analysis: the effects of Lactobacillus rhamnosus GG supplementation for the prevention of healthcare-associated diarrhoea in children

Szajewska, Hania; Wanke, Monika; Patro, Bernadeta

doi:10.1111/j.1365-2036.2011.04837.x

Cited by 104 publications

(83 citation statements)

References 13 publications

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“…In RTCs, L. rhamnosus GG alone or in combination with ORS has demonstrated therapeutic efficacy in significantly reducing by at least half the duration of acute diarrhea mainly resulting from rotavirus infection in children (296)(297)(298)(299)(300)(301)(302)(303)(304)(305)(306)(307)(308)(309)(310). Two meta-analyses have been conducted to specifically examine the RCTs conducted with L. rhamnosus GG (311,312). The conclusion is that L. rhamnosus GG had no impact on the total stool volume but did reduce the duration of diarrhea, particularly in the context of a rotavirus etiology.…”

Section: Therapeutic Effects Against Various Forms Of Acute Diarrheamentioning

confidence: 99%

Anti-Infective Activities of Lactobacillus Strains in the Human Intestinal Microbiota: from Probiotics to Gastrointestinal Anti-Infectious Biotherapeutic Agents

2014

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SUMMARY A vast and diverse array of microbial species displaying great phylogenic, genomic, and metabolic diversity have colonized the gastrointestinal tract. Resident microbes play a beneficial role by regulating the intestinal immune system, stimulating the maturation of host tissues, and playing a variety of roles in nutrition and in host resistance to gastric and enteric bacterial pathogens. The mechanisms by which the resident microbial species combat gastrointestinal pathogens are complex and include competitive metabolic interactions and the production of antimicrobial molecules. The human intestinal microbiota is a source from which Lactobacillus probiotic strains have often been isolated. Only six probiotic Lactobacillus strains isolated from human intestinal microbiota, i.e., L. rhamnosus GG, L. casei Shirota YIT9029, L. casei DN-114 001, L. johnsonii NCC 533, L. acidophilus LB, and L. reuteri DSM 17938, have been well characterized with regard to their potential antimicrobial effects against the major gastric and enteric bacterial pathogens and rotavirus. In this review, we describe the current knowledge concerning the experimental antibacterial activities, including antibiotic-like and cell-regulating activities, and therapeutic effects demonstrated in well-conducted, placebo-controlled, randomized clinical trials of these probiotic Lactobacillus strains. What is known about the antimicrobial activities supported by the molecules secreted by such probiotic Lactobacillus strains suggests that they constitute a promising new source for the development of innovative anti-infectious agents that act luminally and intracellularly in the gastrointestinal tract.

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Section: Therapeutic Effects Against Various Forms Of Acute Diarrheamentioning

confidence: 99%

Anti-Infective Activities of Lactobacillus Strains in the Human Intestinal Microbiota: from Probiotics to Gastrointestinal Anti-Infectious Biotherapeutic Agents

2014

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“…LGG is one of the probiotic bacteria used in clinical trials for treating and/or preventing several diseases, including ulcerative colitis (10), diarrhea (11,12), and atopic dermatitis (13). Our group has purified and cloned a LGG-derived soluble protein, p40, which contains 412 amino acid residues with a calculated molecular mass of 42 kDa (14).…”

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confidence: 99%

A Lactobacillus rhamnosus GG-derived Soluble Protein, p40, Stimulates Ligand Release from Intestinal Epithelial Cells to Transactivate Epidermal Growth Factor Receptor

Yan

Liu

Dempsey

et al. 2013

Journal of Biological Chemistry

135

106

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Background: p40 is a Lactobacillus rhamnosus GG-derived protein.Results: p40 stimulates ADAM17 activation and HB-EGF release, which is required for EGF receptor transactivation, prevention of apoptosis, and preservation of barrier function in intestinal epithelial cells. Conclusion: p40 transactivates the EGF receptor through ADAM17-mediated HB-EGF release in intestinal epithelial cells. Significance: These results define a mechanism of p40 in modulating intestinal epithelial cell homeostasis.

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“…Certain lactobacilli are autochthonous inhabitants of the gastrointestinal tract of animals and humans, where they are considered a beneficial component of the microbiota. In fact, an increasing amount of scientific data demonstrates that intestinal lactobacilli can positively affect the host's health (2,3). Due to their ability to interact with several gut physiological processes, certain human intestinal Lactobacillus species (particularly Lactobacillus acidophilus, L. johnsonii, L. paracasei, L. reuteri, and L. rhamnosus) are commonly employed as probiotics, i.e., live microorganisms that, when administered in adequate amounts, confer benefits to the host organism (4).…”

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confidence: 99%

S-Layer Protein Mediates the Stimulatory Effect of Lactobacillus helveticus MIMLh5 on Innate Immunity

Taverniti

Stuknytė

Minuzzo

et al. 2013

Appl Environ Microbiol

102

110

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fThe ability to positively affect host health through the modulation of the immune response is a feature of increasing importance in measuring the probiotic potential of a bacterial strain. However, the identities of the bacterial cell components involved in cross talk with immune cells remain elusive. In this study, we characterized the dairy strain Lactobacillus helveticus MIMLh5 and its surface-layer protein (SlpA) using in vitro and ex vivo analyses. We found that MIMLh5 and SlpA exert anti-inflammatory effects by reducing the activation of NF-B on the intestinal epithelial Caco-2 cell line. On the contrary, MIMLh5 and SlpA act as stimulators of the innate immune system by triggering the expression of proinflammatory factors tumor necrosis factor alpha and COX-2 in the human macrophage cell line U937 via recognition through Toll-like receptor 2. In the same experiments, SlpA protein did not affect the expression of the anti-inflammatory cytokine interleukin-10. A similar response was observed following stimulation of macrophages isolated from mouse bone marrow or the peritoneal cavity. These results suggest that SlpA plays a major role in mediating bacterial immune-stimulating activity, which could help to induce the host's defenses against and responses toward infections. This study supports the concept that the viability of bacterial cells is not always essential to exert immunomodulatory effects, thus permitting the development of safer therapies for the treatment of specific diseases according to a paraprobiotic intervention.

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Meta-analysis: the effects of Lactobacillus rhamnosus GG supplementation for the prevention of healthcare-associated diarrhoea in children

Abstract: SUMMARY BackgroundIn children, healthcare-associated diarrhoea, in particular, due to rotavirus, may prolong the hospital stay and increase medical costs, prompting interest in effective, low-cost, preventive strategies.

Cited by 104 publications

References 13 publications

Anti-Infective Activities of Lactobacillus Strains in the Human Intestinal Microbiota: from Probiotics to Gastrointestinal Anti-Infectious Biotherapeutic Agents

Anti-Infective Activities of Lactobacillus Strains in the Human Intestinal Microbiota: from Probiotics to Gastrointestinal Anti-Infectious Biotherapeutic Agents

A Lactobacillus rhamnosus GG-derived Soluble Protein, p40, Stimulates Ligand Release from Intestinal Epithelial Cells to Transactivate Epidermal Growth Factor Receptor

S-Layer Protein Mediates the Stimulatory Effect of Lactobacillus helveticus MIMLh5 on Innate Immunity

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