Meta-Analysis: The Effect of Neuropatic Complications and Depression Commorbidity on the Quality of Life of Patients with Type 2 Diabetes

Abstract

Background: Diabetes mellitus is a metabolic disease that results from insulin insufficiency and often causes complications. DM patients are prone to depression. Depression is one aspect that affects the quality of life. Measuring the quality of life in DM patients is done as a measure of the success of the intervention. This study aims to estimate the influence of neuropathic complications and comorbid depression on the quality of life of type 2 DM patients based on the results of previous studies. Subjects and Method: Meta-analysis studies and systematic studies were applied to this research with electronic data sources PubMed, ProQuest, Science Direct, Scopus, Spinger Link and Google Scholar. The key words used were as follows: Comorbidity depression and DM, depression and quality of life and DM and cross sectional study, neuropathy and quality of life and DM and adjusted odd ratio, neuropathy or diabetes, depression or quality of life or DM or adjusted. odd ratio. The article used is a fulltext article with a cross-sectional study design and the results are reported in adjusted odds ratio (aOR). Articles were analyzed using the Review Manager 5.3 application with fixed effect models. Results: Fifteen articles reviewed in this study originated from 5 continents. 6 studies came from the Asian continent (Japan, Iran, Singapore, Korea, China and Nepal), 4 studies from the European continent (Norway and 3 United Kingdom), 2 studies from the African continent (Uganda and Nigeria), 2 studies from the North American continent (Brazil) and 1 study from the continent of South America (USA). The results of the forest plot interpretation showed that patients with type 2 diabetes mellitus with neuropathy complications had 0.78 times the chance of having a good quality of life compared to type 2 DM patients without neuropathic complications (aOR= 0.78; 95% CI= 0.69 to 0.89; p= 0.001). Patients with type 2 DM with comorbid depression had a 0.45 times chance of having a good quality of life compared to type 2 DM patients without comorbid depression (aOR= 0.45; 95% CI= 0.28 to 0.73; p = 0.001). Conclusion:Patients with type 2 DM without complications of neuropathy and without comorbid depression have a better quality of life than patients with type 2 DM with complications of neuropathy and comorbid depression.