Meta-Analysis Shows Strong Positive Association of the TNF-α Gene with Tumor Stage in Bladder Cancer

Yang, Zhifu; Lv, Yajie; Lv, Yali; Wang, Yong

doi:10.1159/000341701

Cited by 13 publications

(5 citation statements)

References 36 publications

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“…A meta‐analysis study has also proved that TNF‐α 308 G/A polymorphism was associated with the risk of urogenital cancer especially in the Caucasian population (Cai, Yang, Hou, & Li, ). Besides, association between a single‐nucleotide polymorphism of the TNF‐α gene promoter (308 A/G) with muscle invasion BC has been previously observed (Raziuddin, Masihuzzaman, Shetty & Ibrahim, ; Z. Yang, Lv, Lv & Wang, ). Increased levels of TNF‐α have been seen in patients with progressive stages of BC (T2–T4) compared with patients with less advanced stages (Ta–T1).…”

Section: Proinflammatory and Anti‐inflammatory Cytokines In Bcmentioning

confidence: 88%

Inflammatory cytokines in bladder cancer

Shadpour

Zamani

Aghaalikhani

et al. 2019

Journal Cellular Physiology

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The presence of inflammatory cells and their products in the tumor microenvironment plays a crucial role in the pathogenesis of a tumor. Releasing the cytokines from a host in response to infection and inflammation can inhibit tumor growth and progression. However, tumor cells can also respond to the host cytokines with increasing the growth/invasion/metastasis. Bladder cancer (BC) is one of the most common cancers in the world. The microenvironment of a bladder tumor has been indicated to be rich in growth factors/inflammatory cytokines that can induce the tumor growth/progression and also suppress the immune system. On the contrary, modulate of the cancer progression has been shown following upregulation of the cytokines‐related pathways that suggested the cytokines as potential therapeutic targets. In this study, we provide a summary of cytokines that are involved in BC formation/regression with both inflammatory and anti‐inflammatory properties. A more accurate understanding of tumor microenvironment creates favorable conditions for cytokines targeting to treat BC.

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Section: Proinflammatory and Anti‐inflammatory Cytokines In Bcmentioning

confidence: 88%

Inflammatory cytokines in bladder cancer

Shadpour

Zamani

Aghaalikhani

et al. 2019

Journal Cellular Physiology

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“…Interestingly, a higher TNF-α concentration was detected in T3 and T4 advanced-stage patients compared to T1 and T2 early-stage patients, indicating that TNF-α level may contribute to the BC progression [ 137 ]. The meta-analysis showed that the −308 A/A+G/A genotype of TNF-α also correlated with the bladder cancer grade [ 138 ]. The SNP is localised in the promoter region of TNF-α and may impact its expression level.…”

Section: Inflammation and Bladder Cancermentioning

confidence: 99%

The Interplay between Oxidative Stress, Inflammation and Angiogenesis in Bladder Cancer Development

Wigner

Grębowski

Bijak

et al. 2021

IJMS

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In 2018, 550,000 people were diagnosed with bladder cancer (BC), of which nearly 200,000 people died. Moreover, men are 4 times more likely than women to be diagnosed with BC. The risk factors include exposure to environmental and occupational chemicals, especially tobacco smoke, benzidine and genetic factors. Despite numerous studies, the molecular basis of BC development remains unclear. A growing body of evidence suggests that inflammation, oxidant-antioxidant imbalance and angiogenesis disorders may play a significant role in the development and progression of bladder cancer. The patients with bladder cancer were characterised by an increased level of reactive oxygen species (ROS), the products of lipid peroxidation, proinflammatory cytokines and proangiogenic factors as compared to controls. Furthermore, it was shown that polymorphisms localised in genes associated with these pathways may modulate the risk of BC. Interestingly, ROS overproduction may induce the production of proinflammatory cytokines, which finally activated angiogenesis. Moreover, the available literature shows that both inflammation and oxidative stress may lead to activation of angiogenesis and tumour progression in BC patients.

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“…Higher levels of TNFA have been correlated with advanced tumor stage and shorter survival in several cancer studies . In particular, TNFA has been associated with tumor stage in UBC. − Clearly, further investigations are required to confirm the discriminative power of these protein candidates as prognosis markers for patients with a prior history of UBC.…”

Section: Resultsmentioning

confidence: 99%

Large-Scale SRM Screen of Urothelial Bladder Cancer Candidate Biomarkers in Urine

et al. 2017

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Urothelial bladder cancer is a condition associated with high recurrence and substantial morbidity and mortality. Noninvasive urinary tests that would detect bladder cancer and tumor recurrence are required to significantly improve patient care. Over the past decade, numerous bladder cancer candidate biomarkers have been identified in the context of extensive proteomics or transcriptomics studies. To translate these findings in clinically useful biomarkers, the systematic evaluation of these candidates remains the bottleneck. Such evaluation involves large-scale quantitative LC-SRM (liquid chromatography-selected reaction monitoring) measurements, targeting hundreds of signature peptides by monitoring thousands of transitions in a single analysis. The design of highly multiplexed SRM analyses is driven by several factors: throughput, robustness, selectivity and sensitivity. Because of the complexity of the samples to be analyzed, some measurements (transitions) can be interfered by coeluting isobaric species resulting in biased or inconsistent estimated peptide/protein levels. Thus the assessment of the quality of SRM data is critical to allow flagging these inconsistent data. We describe an efficient and robust method to process large SRM data sets, including the processing of the raw data, the detection of low-quality measurements, the normalization of the signals for each protein, and the estimation of protein levels. Using this methodology, a variety of proteins previously associated with bladder cancer have been assessed through the analysis of urine samples from a large cohort of cancer patients and corresponding controls in an effort to establish a priority list of most promising candidates to guide subsequent clinical validation studies.

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Meta-Analysis Shows Strong Positive Association of the TNF-α Gene with Tumor Stage in Bladder Cancer

Cited by 13 publications

References 36 publications

Inflammatory cytokines in bladder cancer

Inflammatory cytokines in bladder cancer

The Interplay between Oxidative Stress, Inflammation and Angiogenesis in Bladder Cancer Development

Large-Scale SRM Screen of Urothelial Bladder Cancer Candidate Biomarkers in Urine

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