Meta-analysis Shows Colon Capsule Endoscopy Is Effective in Detecting Colorectal Polyps

Spada, Cristiano; Hassan, Cesare; Marmo, Riccardo; Petruzziello, Lucio; Riccioni, Maria Elena; Zullo, Angelo; Cesaro, Paola; Pilz, Julia Beatrice; Costamagna, Guido

doi:10.1016/j.cgh.2010.02.018

Cited by 95 publications

(68 citation statements)

References 22 publications

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“…In recent years colon capsule endoscopy (CCE) has been under evaluation for visualization of the colon [Eliakim et al 2006[Eliakim et al , 2009Schoofs et al 2006;Sieg et al 2009;Gay et al 2010;Spada et al 2010;Herrerias-Gutierrez et al 2011;Sieg, 2011]. The advantages of CCE as an alternative to the standard colonoscopy as a screening test for colorectal cancer (CRC) might be attractive for a subset of patients.…”

Section: Introductionmentioning

confidence: 99%

Bowel preparation regimens for colon capsule endoscopy: a review

Singhal

Nigar

Paleti

et al. 2013

Therap Adv Gastroenterol

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Colon capsule endoscopy (CCE) is being actively evaluated as an emerging complementary or alternative procedure for evaluation of the colon. The yield of CCE is significantly dependent on the quality of bowel preparation. In addition to achieving a stool-free colon the bowel preparation protocols need to decrease bubble effect and aid propulsion of the capsule. An extensive English literature search was done using PubMed with search terms of colon capsule endoscopy, PillCam and bowel preparation. Full-length articles which met the criteria were included for review. A total of 12 studies including 1149 patients were reviewed. There was significant variability in the type of bowel preparation regimens. Large-volume (3-4 liters) polyethylene glycol (PEG) was the most widely used laxative. Lower volumes of PEG showed comparable results but larger studies are needed to determine efficacy. Sodium phosphate was used as an effective booster in most studies. Magnesium citrate and ascorbic acid are emerging as promising boosters to replace sodium phosphate when it is contraindicated. The potential benefit of prokinetics needs further evaluation. Over the past decade there has been significant improvement in the bowel preparation regimens for CCE. Further experience and studies are likely to standardize the bowel preparation regimens before CCE is adopted into routine clinical practice.

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Section: Introductionmentioning

confidence: 99%

Bowel preparation regimens for colon capsule endoscopy: a review

Singhal

Nigar

Paleti

et al. 2013

Therap Adv Gastroenterol

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“…Capsule endoscopy is generally used as a diagnostic tool for small intestine examinations; however, there are very little data regarding their use for colon examinations. Data that are available regarding their use in colon cancer detection show a sensitivity of 76% and specificity of 75% (28). Virtual colonoscopy has high rates of sensitivity and specificity (95.7% and 100%, respectively).…”

Section: Discussionmentioning

confidence: 99%

Neutrophil-to-Lymphocyte Ratio, Plateletto- Lymphocyte Ratio, and Red Blood Cell Distribution Width as New Biomarkers in Patients with Colorectal Cancer

Çakmak¹,

Soylu²,

Yönem³

et al. 2017

Erciyes Med J

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Objective: The incidence of colorectal cancer in developed countries has been found to increase with age. Early diagnosis and screening decrease the mortality rates in colorectal cancer. This study aimed to use inflammatory markers neutrophil-tolymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and red blood cell distribution width (RDW) as new biomarkers for early diagnosis and screening in patients with colorectal cancer. Materials and Methods:A total of 59 patients with colorectal cancer and 59 age-and sex-matched healthy participants were included in the study. Localization, tumor node metastasis (TNM) stage, and preoperative hemoglobin levels, neutrophil counts, lymphocyte counts, platelet counts, and RDW values were obtained from medical records. Using the receiver operating characteristic (ROC) curve, the optimal cutoff levels of the biomarkers were determined.Results: NLR, PLR, and RDW were significantly higher in patients with colorectal cancer than in healthy participants (p<0.001). According to ROC analysis, the cutoff value for NLR was 2.05 [area under the curve (AUC): 0.740, sensitivity: 78%, specificity: 66%]; the cutoff value for PLR was 130 (AUC: 0.702, sensitivity: 65%, specificity: 72%); and the cutoff value for RDW was 14 (AUC: 0.774, sensitivity: 68%, specificity: 73%).Conclusions: NLR, PLR, and RDW were found to be significantly higher in patients with colorectal cancer than in healthy participants. Therefore, it is recommended that these additional biomarkers can be used for early diagnosis and screening of colorectal cancer.

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“…For the colon, the colonoscopy has been reported to have a failure rate of 22.8% to 26.0% for detecting lesions [20,21] compared with 16% to 33.4% for colonic CE [22,23] . According to these reports, the reasons for detection failure on colonoscopy and CE of the colon include the following: the lesion being hidden by the folds of the large intestine, bowel residue, or feces; technical issues, such as the probe being pulled out suddenly and preventing complete observation; or missing the lesion.…”

Section: (4) Undetected Tumormentioning

confidence: 99%

Investigation of Undetected Small Bowel Tumors on Capsule Endoscopy

Maeda

Hiraishi

2015

Journal of Gastroenterology and Hepatology Research

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CONCLUSION:On CE, small bowel tumors showed atypical features, including a smooth submucosal bulge and the presence of ulcerated lesions and of blood, bowel residue, or feces, probably due to regional transit abnormalities related to the tumor. In such cases, it may be necessary to perform computed tomography, positron emission tomography/computed tomography, other examinations, or repeat CE after performing colonic irrigation to remove bowel residue. RESULTS:Of the 21 patients, CE accurately diagnosed tumors in 12 patients (57.1%). However, tumors were not detected in 9 patients because of a poor endoscopic view due to visual obstruction caused by blood, bowel residue, or feces (n=5; 23.8%), the presence of ulcerated lesions (n=3; 14.3%), or angioectasia (n=1; 4.8%). The sources of bleeding were considered to be ulcerated lesions or angioectasia. Of the 9 patients, 7 patients had tumors in the duodenum or the proximal jejunum. ORIGINAL ARTICLE Investigation of Undetected Small Bowel Tumors on Capsule EndoscopyMitsunori Maeda, Hideyuki Hiraishi Journal of Gastroenterology and Hepatology Researchlesions is a major issue, with the failure to detect neoplastic lesions having a major impact on prognosis. According to the literature, the rate of undetected neoplastic lesions in small-bowel CE is high (44.1% to 83.3%) [1][2][3][4] . Therefore, the aim of this study was to review CE findings in patients with small bowel tumors and analyze cases in which CE failed to detect tumors.

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Meta-analysis Shows Colon Capsule Endoscopy Is Effective in Detecting Colorectal Polyps

Cited by 95 publications

References 22 publications

Bowel preparation regimens for colon capsule endoscopy: a review

Bowel preparation regimens for colon capsule endoscopy: a review

Neutrophil-to-Lymphocyte Ratio, Plateletto- Lymphocyte Ratio, and Red Blood Cell Distribution Width as New Biomarkers in Patients with Colorectal Cancer

Investigation of Undetected Small Bowel Tumors on Capsule Endoscopy

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