Meta-analysis shows association between the tryptophan hydroxylase (TPH) gene and schizophrenia

Li, Dawei; He, Lin

doi:10.1007/s00439-006-0190-5

Cited by 31 publications

(18 citation statements)

References 49 publications

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“…In accordance with the findings of Li & He (2006), the polymorphism of the A779C gene, briefly called TPH1 (see above for the details), was one of two polymorphisms associated with schizophrenia. These findings immediately created a link with the discussion on the madness-creativity affinity on the grounds of a partly common genetic basis; however, more evidence pointed to affective disorders rather than schizophrenia or similar disorders as being implicated.…”

Section: Molecular Genetics Contributes To Creativity -Mood Disorderssupporting

confidence: 65%

The Creative Side of Mood Disorders

Chruszczewski

2014

Creativity

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The paper describes the relationship between creativity and mood disorders. After outlining the main directions of research in this field, the nature of the ascertained correlation between creativity and mood disorders is analysed from a theoretical perspective. Psychological and biological approaches are taken into account. The first is focused on the significance of periods of mania and their influence on cognitive and motivational processes; the second is focused on genetic aspects. A compromise hypothesis based on both approaches is proposed and discussed, in which creativity and mood disorders, although co-determined by basic genetic factors are not independent and influence each other mutually.The psychology of individual differences places creativity at the crossroads of personality and intelligence (Aguilar-Alonso, 1996;Eysenck, 1995a). Both can be affected by disorders. Therefore, it would seem that deficiencies in the sphere of personality or intellect caused by psychological disorders would inhibit creative activity. An assumption of this kind might potentially be true, under one condition: that creativity is fostered only by those individual traits that are associated with good adaptation. However, in the light of philosophical reflections dating back to antiquity, and empirical studies which have been conducted for at least seventy years (for an example see Eysenck, 1994), this is not the case.In discussions on the relationship between creativity and psychological disorders Plato and Aristotle are often quoted. The first of them (see "Phaedrus", XXII, by Plato, IVth century BC/1993) emphasised the affinity of art and madness, and argued that art -treated as being born from divine madness (mania sui generis) -is superior to all kinds of academism. Plato also stressed the particular proximity of that madness to poetry. The second of them, Aristotle, linked melancholia (which means depression or at least dysthymia in modern psychology terms) with eminence in various domains, not only artistic, but also in philosophy and politics (cf. "Problemata"

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Section: Molecular Genetics Contributes To Creativity -Mood Disorderssupporting

confidence: 65%

The Creative Side of Mood Disorders

Chruszczewski

2014

Creativity

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“…A meta-analysis showed a significant association between TPH1 218A/C and schizophrenia (Li and He, 2006b). The newly updated schizophrenia gene meta-analysis revealed that TPH1 is one of the four genes positively associated with schizophrenia, showing strong epidemiological credibility (Allen et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

TPH2 gene polymorphisms in the regulatory region are associated with paranoid schizophrenia in Northern Han Chinese

Xu¹,

Ding²,

Pang³

et al. 2014

Genet. Mol. Res.

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ABSTRACT. In the last years, serotonin (5-HT) has been related with the pathophysiology of several psychiatric disorders, including schizophrenia. Thus, genes related to the serotonergic (5-HTergic) system are good candidate genes for schizophrenia. The rate-limiting enzyme of 5-HT synthesis is tryptophan hydroxylase 2 (TPH2). Single nucleotide polymorphisms (SNPs) in the regulatory regions of TPH2 gene may affect gene expression and biosynthesis of 5-HT triggering to various neuropsychiatric disorders related to 5-HT dysfunction. The present study explored the association of SNPs within the TPH2 gene with paranoid schizophrenia in Han Chinese. A total of 164 patients with schizophrenia and 244 healthy controls were genotyped for six TPH2 SNPs (rs4570625, rs11178997, rs11178998, rs41317118, rs17110747, and rs41317114). Significant group differences were observed in the allele and genotype frequencies of rs4570625 and in the frequencies of GTA and TTA haplotypes corresponding to rs4570625-rs11178997-rs11178998. Our findings suggest that common genetic variations of TPH2 are likely to contribute to genetic susceptibility to paranoid schizophrenia in Han Chinese. Further studies in larger samples are needed to replicate this association.

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“…Nevertheless, association studies and even recent meta-analytic evidence have produced conflicting results (Li and He 2006;Abdolmaleky et al 2004;Fan and Sklar 2005). HTR2A is widely distributed in the brain, with highest concentrations in the cortex (Hoyer et al 1986), and is localized on cortical and hippocampal pyramidal glutamatergic neurons (Jakab and GoldmanRakic 1998), as well as on g-aminobutyric acid (GABA)ergic interneurons (Willins et al 1997), both of which play a key role in schizophrenia.…”

Section: Introductionmentioning

confidence: 98%

“…Genetic variation of TPH1 gene has been associated with the risk of schizophrenia in previous reports (Zaboli et al 2006;Anttila et al 2007). Metaanalysis study showed a significant association between 218A/C and schizophrenia (Li and He 2006). In contrast to TPH1, TPH2 is expressed in the raphe nucleus and directly affects the serotonergic pathways of the brain (Patel et al 2004).…”

Section: Introductionmentioning

confidence: 98%

Effect of Serotonin-Related Gene Polymorphisms on Pathogenesis and Treatment Response in Korean Schizophrenic Patients

Kim

Yoon

2011

Behav Genet

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Serotonin has been implicated in the pathophysiology of several psychiatric disorders including schizophrenia. Serotonergic system-related genes may be good candidates in investigating the genetic basis of schizophrenia. We aimed to investigate the associations of HTR1A C-1019G, HTR2A-1438A/G, TPH1 218A/C, and TPH2-703G/T variants with schizophrenia. A total of 202 patients with schizophrenia and 165 normal controls were genotyped for HTR1A C-1019G, HTR2A-1438A/G, TPH1 218A/C, and TPH2-703G/T single nucleotide polymorphisms (SNPs). In order to assess the severity of a patient's psychiatric symptoms, the brief psychiatric rating scale (BPRS), the positive and negative symptom scale (PANSS), and the Calgary depression scale for Schizophrenia (CDSS) were administered. Genotype and allele frequencies were compared between groups via χ(2) statistics. Associations between the genotypes of candidate SNPs with the severity of symptoms were examined with ANOVA by comparing the mean scores of BPRS, PANSS, and CDSS according to genotype. No significant differences in the genotype distributions and allele frequencies of four SNPs were found between patients with schizophrenia and normal controls. There was a trend towards association of HTR1A C-1019G polymorphism with negative symptom. Negative symptom score of PANSS was lower in the patients with CC genotype than in the G allele carriers. These results suggested that C allele might be associated with lesser negative symptom. More studies are needed to confirm these findings. In the future, we plan to study the associations between schizophrenia and other genetic polymorphisms.

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Meta-analysis shows association between the tryptophan hydroxylase (TPH) gene and schizophrenia

Cited by 31 publications

References 49 publications

The Creative Side of Mood Disorders

The Creative Side of Mood Disorders

TPH2 gene polymorphisms in the regulatory region are associated with paranoid schizophrenia in Northern Han Chinese

Effect of Serotonin-Related Gene Polymorphisms on Pathogenesis and Treatment Response in Korean Schizophrenic Patients

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