We carefully read the article "Lower limb muscle size after anterior cruciate ligament injury: a systematic review and meta-analysis" by Dutaillis et al. [1]. The authors explored the effect of anterior cruciate ligament injury on muscle size in the lower limbs and found that the quadriceps muscle of the injured limb after an anterior cruciate ligament injury is smaller than the equivalent muscle of the uninjured limb. When semitendinosus/gracilis tendon grafts were used for reconstruction, the harvested muscle showed a smaller muscle size than the uninjured limb. The methodology used by the authors involved a meta-analysis. Although the authors' analytical methods were scientific, we think there are some problems in this paper that need to be improved.