Meta-analysis on the effect of combining Lianhua Qingwen with Western medicine to treat coronavirus disease 2019

Wang, Deng-Chao; Yu, Miao; Xie, Wenxian; Huang, Liyan; Ji, Wei; Lei, Yue-Hua

doi:10.1016/j.joim.2021.10.005

Cited by 11 publications

(20 citation statements)

References 23 publications

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“…that failed to report the risk of bias assessment tool they used in the article, Liu et al [ 22 ] . and Wang et al [ 26 ] . used the Newcastle-Ottawa Scale (NOS) and Cochrane risk of bias tool.…”

Section: Resultsmentioning

confidence: 99%

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An umbrella review of Lianhuaqingwen combined with Western medicine for the treatment of coronavirus disease 2019

Yang

Zhang

Zhao

et al. 2022

Acupuncture and Herbal Medicine

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Objective: Lianhua Qingwen combined with Western medicine (LHQW+WM) has been proposed as a viable treatment for coronavirus disease 2019 . Interestingly, umbrella reviews of systematic reviews (SRs), which provide the most comprehensive evidence, are the best evidence in evidence-based medicine. Therefore, an umbrella review of SRs that summarizes and evaluates the efficacy of LHQW+WM for COVID-19 is urgently required.Methods: Overall, 6 databases were used to conduct a comprehensive literature search from inception to January 22, 2022. The corrected covered area (CCA) was used to analyze the overlapping between SRs. Meta-analysis was conducted when that of the included SRs was inappropriate. A MeaSurement Tool to Assess Systematic Reviews (AMSTAR-2) was also employed to assess the quality of the included SRs.Results: In total, 12 SRs were identified, which included 12 unique primary studies. The included SRs ranged in quality from moderate to critically low and had an extremely high CCA (36.4%). Compared to conventional treatment, LHQW+WM showed efficacy concerning fatigue recovery [risk ratio (RR) = 1.69, 95% confidence interval (CI): 1.04-2.73, n = 2, I 2 = 0%], cough recovery (RR = 1.65, 95% CI: 1.09-2.51, n = 3, I 2 = 39.1%), and overall effective rates (RR = 1.17, 95% CI: 1.07-1.28, n = 3, I 2 = 17.5%).Conclusion: LHQW+WM may improve the clinical symptoms of patients with COVID-19; however, the results should be interpreted cautiously because of the rigorous processes in the included SRs.

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Section: Resultsmentioning

confidence: 99%

“…Supplementary Table 1, http://links.lww.com/AHM/A25 , presents the citation metrics. Additionally, for SRs with almost complete overlap of the primary studies, there was only one primary study [ 37 ] in Wang et al [ 26 ] . compared to Fan et al [ 23 ] ., and Lyu et al [ 38 ] .…”

Section: Resultsmentioning

confidence: 99%

An umbrella review of Lianhuaqingwen combined with Western medicine for the treatment of coronavirus disease 2019

Yang

Zhang

Zhao

et al. 2022

Acupuncture and Herbal Medicine

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“…At the same time, our report also provides the aggravation rate of conversion to severe cases and the results of the intervention group in improving clinical symptoms (fever, cough, fatigue, chest tightness, shortness of breath, expectoration) and shortening the duration of fever. In the meta-analysis of Wang et al (2022), the result of Wang et al (2020) was not included in the overall effective rate, and the study did not report chest computed tomography manifestations and the aggravation rate of conversion to severe cases. In Zeng et al (2020) 's study, only 2 studies were included.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and Safety of Chinese Medicine Lianhua Qingwen for Treating COVID-19: An Updated meta-Analysis

Liu

Zhang

2022

Front. Pharmacol.

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The traditional Chinese medicine formula Lianhua Qingwen (LQ) combined with western medicine therapy is beneficial to coronavirus disease-19 (COVID-19), but there is still a lack of strong evidence-based. We conducted a systematic review and meta-analysis to evaluate the efficacy and safety of LQ combined with western medicine for patients with COVID-19. Seven databases (Chinese and English) were searched by two independent reviewers. Search for relevant keywords such as “Chinese medicine,” “Chinese herbal medicine,” and “Lianhua Qingwen” in the titles and abstracts of articles retrieved in the databases. Randomized controlled trials or case-control studies that reported sufficient data of participants before and after the intervention were included. Two researchers independently reviewed the studies and extracted the data. Fixed-or random-effect model was used to calculate the overall pooled risk estimates. Forest plots were generated to show pooled results. Seven studies involving 916 participants were included in the meta-analysis. Overall, compared with the control group, the total efficacy (OR = 2.23, 95% CI 1.56, 3.18), adverse events (OR = 0.42, 95% CI 0.18, 0.97), chest computed tomography manifestations (OR = 1.74, 95% CI 1.12, 2.72), and aggravation rate of conversion to severe cases (OR = 0.47, 95% CI 0.30, 0.75) of the intervention group were better. Moreover, the intervention group has an advantage over the control group in improving clinical symptoms (fever, cough, fatigue, chest tightness, shortness of breath, and expectoration) and shortening the fever duration (p < 0.05). Our findings indicate that LQ combined with western medicine may be more effective in treating COVID-19. However, due to the urgency of SARS-CoV-2 outbreaks leading to low methodological quality and not rigorous designs. This meta-analysis cannot draw clear conclusions. PROSPERO registration number: CRD42020190757

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“…Combination therapy was more successful than Western medicine single-handedly. A possible approach could be the up-regulation of antiviral features and the down-regulation of pro-inflammatory mediators [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

Traditional herbs against COVID-19: back to old weapons to combat the new pandemic

et al. 2022

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Background Recently, the coronavirus (COVID-19) pandemic is a chief public health disaster caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). There are no established effective preventive or therapeutic anti-COVID-19 drugs available except for some recently approved vaccines. Still, countless recent studies recommend various alternative and complementary approaches against COVID-19, which are medicinal herbs employed as traditional remedies to enhance immunity to struggle with viral infections. In addition, physicians worldwide are highly interested in vitamin and mineral supplements to help them combat COVID-19 either through protection or treatment. Dietary supplements specifically vitamin D, vitamin C, and zinc provide good prophylactic and therapeutic support to the presently available treatment regimens. In the present work, we have focused on plant-based remedies with promising anti-COVID-19 activities. Aim To enable investigators and researchers to identify potential herbal compounds with anti-COVID activity to be used as promising therapies to combat this pandemic. Main body This review highlights the recently published studies concerning natural traditional herbs, herbal bioactive metabolites, dietary supplements, and functional foods that could help prevent and/or treat COVID-19. Herein, we explored medicinal herbs as potential inhibitors of SARS-CoV-2 and discussed how these studies help form larger discussions of diet and disease. Moreover, by investigating the herbal bioactive components, we have outlined several medicinal herbs that can fight against COVID-19 by hindering SARS-CoV-2 replication and entry to its host cells, deterring the cytokine storm, and several other means. Finally, we have summarized various herbal products, functional foods, and dietary supplements with potent bioactive compounds which can inhibit and/or prevent COVID-19 disease progression. Conclusions Based on the studies reviewed in this work, it was concluded with no doubt that phytochemical components present in various herbs could have a starring role in the deterrence and cure of coronavirus contagion.

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Meta-analysis on the effect of combining Lianhua Qingwen with Western medicine to treat coronavirus disease 2019

Cited by 11 publications

References 23 publications

An umbrella review of Lianhuaqingwen combined with Western medicine for the treatment of coronavirus disease 2019

An umbrella review of Lianhuaqingwen combined with Western medicine for the treatment of coronavirus disease 2019

Efficacy and Safety of Chinese Medicine Lianhua Qingwen for Treating COVID-19: An Updated meta-Analysis

Traditional herbs against COVID-19: back to old weapons to combat the new pandemic

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