Meta-analysis on Brain Representation of Experimental Dental Pain

Lin, Cheng‐Jian; Niddam, David M.; Hsu, Ming Lun

doi:10.1177/0022034513512654

Cited by 21 publications

(36 citation statements)

References 37 publications

(55 reference statements)

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“…In keeping with our results, the previously mentioned meta-analysis of dental neuroimaging studies demonstrated predominantly mid-insular activations (Lin et al, 2014). One might therefore speculate that there might be a somatotopic organization within the insular cortex as previously suggested (Mazzola et al, 2009).…”

Section: Discussionsupporting

confidence: 92%

“…Our findings of the pain phase correspond to results previously reported in dental pain neuroimaging studies with the exception of absent activity in somatosensory cortices (table 1a) Jantsch et al, 2005;Lin et al, 2014). Although a somatotopic S1 activation of different facial stimulation sites could be demonstrated (DaSilva et al, 2002), the meta-analysis of Lin et al revealed inconsistent findings in this area as they reported a lack of S1 activity in 2 out of 6 studies (Lin et al, 2014), indicating that the response in this cortical area is less robust than in others.…”

Section: Discussionsupporting

confidence: 91%

“…Although a somatotopic S1 activation of different facial stimulation sites could be demonstrated (DaSilva et al, 2002), the meta-analysis of Lin et al revealed inconsistent findings in this area as they reported a lack of S1 activity in 2 out of 6 studies (Lin et al, 2014), indicating that the response in this cortical area is less robust than in others. Peyron et al…”

Section: Discussionmentioning

confidence: 96%

“…Considering the 130 year history of local anesthetics in dentistry remarkably little knowledge exists on their effects on the human brain. A meta-analysis recently summarized the relatively sparse evidence regarding the representation of experimental dental pain in the human brain (Lin et al, 2014). It revealed a cerebral network which mainly includes primary and secondary somatosensory cortices (S1 and S2), insula, thalamus, cingulate cortex and frontal brain regions.…”

Section: Introductionmentioning

confidence: 99%

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The Human Brain Response to Dental Pain Relief

et al. 2015

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Local anesthesia has made dental treatment more comfortable since 1884, but little is known about associated brain mechanisms. Functional magnetic resonance imaging is a modern neuroimaging tool widely used for investigating human brain activity related to sensory perceptions, including pain. Most brain regions that respond to experimental noxious stimuli have recently been found to react not only to nociception alone, but also to visual, auditory, and other stimuli. Thus, presumed functional attributions have come under scrutiny regarding selective pain processing in the brain. Evidently, innovative approaches are warranted to identify cerebral regions that are nociceptive specific. In this study, we aimed at circumventing known methodological confounders by applying a novel paradigm in 14 volunteers: rather than varying the intensity and thus the salience of painful stimuli, we applied repetitive noxious dental stimuli at constant intensity to the left mandibular canine. During the functional magnetic resonance imaging paradigm, we suppressed the nociceptive barrage by a mental nerve block. Brain activity before and after injection of 4% articaine was compared intraindividually on a group level. Dental pain extinction was observed to correspond to activity reduction in a discrete region of the left posterior insular cortex. These results confirm previous reports demonstrating that direct electrical stimulation of this brain region-but not of others-evokes bodily pain sensations. Hence, our investigation adds further evidence to the notion that the posterior insula plays a unique role in nociceptive processing. The human brain response to dental pain relief AbstractLocal anesthesia has made dental treatment more comfortable since 1884, but little is known about associated brain mechanisms. Functional magnetic resonance imaging (fMRI) is a modern neuroimaging tool widely used for investigating human brain activity related to sensory perceptions, including pain. Recently, most brain regions that respond to experimental noxious stimuli have been found to react not only to nociception alone, but also to visual, auditory and other stimuli. Thus, presumed functional attributions have come under scrutiny regarding selective pain processing in the brain. Evidently, innovative approaches are warranted to identify cerebral regions that are nociceptivespecific. In this study, we aimed at circumventing known methodological confounders by applying a novel paradigm in 14 volunteers: rather than varying the intensity and thus the salience of painful stimuli, we applied repetitive noxious dental stimuli at constant intensity to the left mandibular canine.During the fMRI paradigm we suppressed the nociceptive barrage by a mental nerve block. Brain activity before and after injection of 4% articaine was compared intra-individually on a group level.Dental pain extinction was observed to correspond to activity reduction in a discrete region of the left posterior insular cortex. These results confirm previous reports dem...

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Human Brain Response to Dental Pain Relief

et al. 2015

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show abstract

“…One recent meta‐analysis disclosed the mechanisms of how sensory and cognitive‐affective factors shape dental pain (Lin et al . ), suggesting a role of reappraisal and coping in the experience of OP.…”

Section: Introductionmentioning

confidence: 99%