Meta-analysis of the relationship between the number and location of perivascular spaces in the brain and cognitive function

Liu, Ling; Tu, Liangdan; Shen, Qiuyan; Bao, Yi; Xu, Fang; Zhang, Dan; Xu, Yanming

doi:10.1007/s10072-024-07438-3

Cited by 1 publication

(1 citation statement)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus the maximum possible total dPVS score is 9 when we combine all three brain regions. 31 Given that our focus was on the dPVS in the BG and CSO due to the potential association with cognitive deficits in elderly adults, 25,33 we limited our evaluation to the BG and CSO dPVS. In addition, based on analysis from other studies, 34,35 we then categorized the BG and CSO dPVS burden scores into low (0-1 points) and mod-erate/high (2-4 points) for statistical analysis.…”

Section: Dpvs Rating Scalementioning

confidence: 99%

Quantifying dilated perivascular spaces in children with sickle cell disease

Karkoska,

Gollamudi,

Sawyer

et al. 2024

Pediatric Blood & Cancer

View full text Add to dashboard Cite

Sickle cell disease (SCD)‐related neurological effects are particularly devastating. Dilated perivascular spaces (dPVS) are a well‐described component of cerebral small vessel disease in older adults without SCD. However, the burden and association of dPVS with neurological complications in children with SCD have not been described. In this study, we used the international consensus criteria to quantify dPVS in the centrum semiovale and basal ganglia in T2‐weighted magnetic resonance images (MRI) of children with SCD who were randomized as part of the Silent Cerebral Infarct Transfusion (SIT) trial. We examined the relationship between global and/or regional dPVS burden and presence or area of silent cerebral infarctions, hematological measures, demographic variables, and full‐scale intelligence quotient (FSIQ) scores. The study included 156 SIT trial participants who had pre‐randomization and study exit MRI. Their median age was 9.6 (5–15) years, 39% were female, and 94 (60%) participants had a high dPVS burden. Participants randomized to the blood transfusion arm and who had a high dPVS burden at baseline had a moderate decline in dPVS score over 36 months compared to no change in the observation group. On multivariable logistic regression, intelligence quotient was not associated with dPVS burden. Children with SCD included in the SIT trial have a high burden of dPVS compared to children without SCD. However, dPVS do not appear to have the same pathophysiology of silent cerebral infarcts. Further study is needed to determine both their etiology and clinical relevance.

show abstract