Meta-analysis of the relation between irritable bowel syndrome and antibodies against endogenous gonadotropin-releasing hormone and its receptor

Motawea, Karam R.; Varney, Joseph; Gamal, Mohamed; Abbas, Kirellos Said; Monib, Fatma A.; Albuni, Mhd Kutaiba; Battikh, Elias; Sawaf, Bisher; Khairy, Lina Taha; Bakkour, Agyad; Muwaili, Ali Hadi Hussein; Abdelmajid, Fatima Abubaker Abdalla; Ahmed, Eman Mohammed Sharif; Muwaili, Dhuha Hadi Hussein; Ahmed, Safaa Mohamed Alsharief; Swed, Sarya

doi:10.1080/08998280.2022.2093588

Cited by 2 publications

(1 citation statement)

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“…Antibodies against gonadotropin-releasing hormone (GnRH) and a reduced number of GnRH-containing neurons in the ENS were sporadically found in patients with IBS ( Ohlsson et al, 2010 ), and 11 out of 26 patients with IBS were found to be positive for IgM antibodies to GnRH ( Ohlsson et al, 2011 ). Motawea et al conducted a meta-analysis and reported a statistically significant association between IBS and increased prevalence of GnRH IgM antibodies (risk ratio = 2.29) ( Motawea et al, 2022 ). In 2012, Wood et al observed that the positivity rate of anti-enteric neuronal antibodies (AENA) was higher in IBS patients than in non-IBS controls using whole-mount ENS preparations as substrates, which provided substantial evidence of the potential involvement of autoimmunity in ENS ( Wood et al, 2012 ).…”

Section: Autoantibodies Documented In Ibs Patientsmentioning

confidence: 99%

Role of autoantibodies in the pathophysiology of irritable bowel syndrome: a review

Zhang,

Liao,

Fan

2024

Front. Physiol.

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Irritable bowel syndrome (IBS) is a chronic, recurrent disorder that is characterized by abdominal pain associated with defecation. IBS was previously considered to manifest without any structural alterations until the discovery of post-infection IBS. An increasing body of published evidence indicates that immune activation plays an important role in the development of IBS. Nevertheless, the pathophysiology of IBS, including mainly visceral hypersensitivity and gastrointestinal dysmotility, has not yet been explicitly elucidated. The observation of potential inflammatory degenerative neuropathy, including neuronal degeneration, spearheaded research on autoimmune responses targeting the enteric nervous system. Subsequently, several autoantibodies were detected in the sera of IBS patients, among which some were presumed to exert a pathogenic influence or be associated with the etiology of gastrointestinal dysmotility in IBS. Moreover, certain specific autoantibodies evidently served as biomarkers to facilitate the differentiation between IBS and other related diseases. Therefore, we aimed to present an overview of autoantibodies reported in the sera of IBS patients and highlight their significance in diagnosing and comprehending the pathophysiology of IBS. Consequently, we propose a therapeutic strategy from an autoimmune perspective.

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