Meta-analysis of the association between the rs7903146 polymorphism at the TCF7L2 locus and type 2 diabetes mellitus susceptibility

Abstract

ABSTRACT. Type 2 diabetes mellitus (T2DM) is a chronic disease caused by genetic and environmental factors. T2DM has been associated with specific polymorphisms in the TCF7L2 gene. This study evaluates the relationship between the rs7903146 locus polymorphism of the TCF7L2 gene and T2DM susceptibility through meta-analysis; the overall aim is to provide a basis for evidence-based medicinal treatment of T2DM. Cohort and case-control studies from Medline, PubMed, EMBASE, CBM, CNKI, and academic conferences/dissertations that examined the correlation between T2DM and rs7903146 polymorphisms were evaluated. We determined whether the TCF7L2 rs7903146 locus was associated with T2DM susceptibility by comparing alleles and genotypes. The Stata 11.0 software was applied for meta-analysis, and a random-effects model was adopted for heterogeneity testing and odds ratio (OR) calculation. A fixed-effect model was used for quantitative analysis of the heterogeneity between different studies, and for calculating the percentage of variability 16857 rs7903146 polymorphism in TCF7L2 and type 2 diabetes mellitus ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (4): 16856-16862 (2015) I 2 . A total of 10 studies related to the rs7903146 loci and T2DM susceptibility were enrolled; this included 3404 cases of T2DM patients and 6473 control cases. Meta-analysis showed that the T allele of rs7903146 was significantly correlated with the risk of T2DM, with both a dominant fixedeffect model (OR = 1.653, 95%CI = 1.416-1.653) and a co-dominant-fixed effect model (OR = 1.525, 95%CI = 1.350-1.723). Meta-analysis revealed that the T allele of rs7903146 was also correlated with T2DM susceptibility.

Sex-specific associations of TCF7L2 variants with fasting glucose, type 2 diabetes and coronary heart disease among Turkish adults

“…Similar findings were found in a meta-analysis conducted by Peng et al ( 14 ), which revealed that -47833C>T and -98368G>T variants are associated with higher type 2 diabetes risk. Similarly, meta-analysis results reported by Liu et al ( 15 ) and Dou et al ( 16 ) showed a significant association between -47833C>T and type 2 diabetes susceptibility in different populations. Our findings are in agreement with those reported by Chandak et al ( 29 ), who showed that -98368TT genotype increases fasting plasma glucose levels in the Indian population and that both of the most common variants are associated with type 2 diabetes in diabetic and nondiabetic individuals.…”

Dissecting heterogeneity in paediatric Type 1 diabetes: association of TCF7L2 rs7903146 TT and low‐risk human leukocyte antigen (HLA) genotypes

“…The TCF7L2 gene harbours several single nucleotide polymorphisms (SNPs) in strong linkage disequilibrium that tag the strongest genetic association with Type 2 diabetes . The TCF7L2 SNP with the most robust association and consistency across races/ethnicities of individuals with Type 2 diabetes is rs7903146, widely considered the causal variant at this locus .…”

Association between transcription factor 7-like 2 genetic polymorphisms and development of type 2 diabetes in a Chinese population

“…TCF7L2 expression is related to its proposed function in insulin secretion. Several previous studies have examined the role of the TCF7L2 rs7903146 polymorphism in the development of type 2 diabetes mellitus, but their results have been inconclusive (Assmann et al, 2014;Barros et al, 2014;Allahdini et al, 2015;GuewoFokeng et al, 2015;Liu et al, 2015;Nanfa et al, 2015;Yao et al, 2015;Yang et al, 2015). In this study, we conducted a hospital-based case-control investigation to evaluate the relationship between TCF7L2 rs7903146 and risk of developing type 2 diabetes mellitus in a Chinese population.…”