Meta-analysis of the association between major foods with added fructose and non-alcoholic fatty liver disease

Liu, Wenqi; Zhai, Daokuan; Zhang, Tingjing; Mudoti, Nyasha Grace; Chang, Qing; Liu, Yashu; Zhao, Yuhong; Yang, Ding; Xia, Yang

doi:10.1039/d3fo00882g

Cited by 3 publications

(1 citation statement)

References 55 publications

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“…In our study, the NAFL group exhibited a higher frequency of consumption of products rich in monosaccharides, which is consistent with the findings of Tseng et al, who reported a positive correlation between the consumption of monosaccharides in the form of sweetened beverages and NAFLD occurrence [48]. Based on a meta-analysis of 15 articles encompassing 15,149 individuals, Liu specified that fructose primarily caused liver fat accumulation [49].…”

Section: Discussionsupporting

confidence: 91%

Lifestyle and Quality of Life of Women Diagnosed with Hypothyroidism in the Context of Non-Alcoholic Fatty Liver

Janota,

Adamek,

Szczepańska

et al. 2023

Metabolites

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Interconnections between hypothyroidism and metabolic disturbances manifesting in the liver and body composition have not yet been comprehensively analyzed in the context of lifestyle. This study aimed to assess the selected lifestyle factors and quality of life in the context of the development of NAFL (non-alcoholic fatty liver) in women diagnosed with hypothyroidism. This study included 134 women categorized into three groups: with hypothyroidism and NAFL, with only hypothyroidism, and with only NAFL. We compared the groups concerning the KomPAN and WHOQOL-BREF questionnaires, anthropometric measurements, body composition parameters, and the stage of liver steatosis. The individuals with NAFL most frequently consumed lard, fried dishes, processed meats, red meat, sweets, and sweetened beverages. The individuals with hypothyroidism without coexisting NAFL exhibited the highest satisfaction with health. The NAFL group had the highest average body fat percentage. Selected lifestyle aspects influenced the development of NAFL in women diagnosed with hypothyroidism. Women’s overall quality of life did not vary depending on the coexisting medical conditions. Preventive programs should promote the following: the regular consumption of meals, the appropriate energy supply, physical activity, mental health support, and striving for proper body composition parameters.

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Section: Discussionsupporting

confidence: 91%

Lifestyle and Quality of Life of Women Diagnosed with Hypothyroidism in the Context of Non-Alcoholic Fatty Liver

Janota,

Adamek,

Szczepańska

et al. 2023

Metabolites

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Gubra Amylin‐NASH Diet Induced Nonalcoholic Fatty Liver Disease Associated with Histological Damage, Oxidative Stress, Immune Disorders, Gut Microbiota, and Its Metabolic Dysbiosis in Colon

Zhang,

Qin,

et al. 2024

Molecular Nutrition Food Res

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ScopeThe overall changes of colon under nonalcoholic fatty liver disease (NAFLD) remain to be further elucidated.Methods and ResultsThis study establishes a mouse model of NAFLD through a long‐term Gubra Amylin‐nonalcoholic steatohepatitis (NASH) diet (GAN diet). The results show that GAN diet significantly induces weight gain, liver steatosis, colonic oxidative stress, and lipid accumulation in blood, liver, and adipose tissue in mice. GAN feeding reduces the diversity of the gut microbiota, alters the composition and abundance of the gut microbiota, and leads to an increase in microbial metabolites such as long‐chain fatty acids (LCFAs) and secondary bile acids (BAs), as well as a decrease in short‐chain fatty acids (SCFAs). The RNA‐seq and immunofluorescence results reveal that the GAN diet alters the expression of proteins and their coding genes involved in oxidative stress, immune response, and barrier function in colon tissue, such as lipocalin‐2 (Lcn2, p < 0.05), heme oxygenase‐1 (HO‐1/Hmox1, p < 0.05), interferon‐gamma (IFN‐γ), and claudin‐3/7. In addition, correlation analysis indicates a strong correlation between the changes in gut microbiota and lipid biomarkers. Additionally, the expression of immune related genes in colon tissue is related to the LCFAs produced by microbial metabolism.ConclusionGAN‐induced NAFLD is related to microbiota and its metabolic imbalance, oxidative stress, immune disorders, and impaired barrier function in colon.

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Beneficial Effects of the Ketogenic Diet on Nonalcoholic Fatty Liver Disease (NAFLD/MAFLD)

Dyńka,

Rodzeń,

Rodzeń

et al. 2024

JCM

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The prevalence of nonalcoholic fatty liver disease (NAFLD) is likely to be approaching 38% of the world’s population. It is predicted to become worse and is the main cause of morbidity and mortality due to hepatic pathologies. It is particularly worrying that NAFLD is increasingly diagnosed in children and is closely related, among other conditions, to insulin resistance and metabolic syndrome. Against this background is the concern that the awareness of patients with NAFLD is low; in one study, almost 96% of adult patients with NAFLD in the USA were not aware of their disease. Thus, studies on the therapeutic tools used to treat NAFLD are extremely important. One promising treatment is a well-formulated ketogenic diet (KD). The aim of this paper is to present a review of the available publications and the current state of knowledge of the effect of the KD on NAFLD. This paper includes characteristics of the key factors (from the point of view of NAFLD regression), on which ketogenic diet exerts its effects, i.e., reduction in insulin resistance and body weight, elimination of fructose and monosaccharides, limitation of the total carbohydrate intake, anti-inflammatory ketosis state, or modulation of gut microbiome and metabolome. In the context of the evidence for the effectiveness of the KD in the regression of NAFLD, this paper also suggests the important role of taking responsibility for one’s own health through increasing self-monitoring and self-education.

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Meta-analysis of the association between major foods with added fructose and non-alcoholic fatty liver disease

Abstract: Objectives: The relationship between the consumption of foods with added fructose and non-alcoholic fatty liver disease (NAFLD) was inconsistent in previous epidemiological studies, and no meta-analysis has been performed on...

Cited by 3 publications

References 55 publications

Lifestyle and Quality of Life of Women Diagnosed with Hypothyroidism in the Context of Non-Alcoholic Fatty Liver

Lifestyle and Quality of Life of Women Diagnosed with Hypothyroidism in the Context of Non-Alcoholic Fatty Liver

Gubra Amylin‐NASH Diet Induced Nonalcoholic Fatty Liver Disease Associated with Histological Damage, Oxidative Stress, Immune Disorders, Gut Microbiota, and Its Metabolic Dysbiosis in Colon

Beneficial Effects of the Ketogenic Diet on Nonalcoholic Fatty Liver Disease (NAFLD/MAFLD)

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