Meta-analysis of the association between common interleukin-1 polymorphisms and dental implant failure

Abstract

Interleukin-1 (IL) plays a pivotal role in immune-inflammatory response that maintains periodontal homeostasis. A number of epidemiological studies have been conducted to investigate the associations between common polymorphisms of IL-1 (IL-1A, IL-1B) genes and risk of peri-implant disease, but the findings remain inconclusive. Thirteen studies evaluating the association between IL-1 polymorphisms and risk for peri-implant diseases (implant failure/loss, peri-implantitis) were included. Fixed model or random-effects models were applied to calculate overall and ethnicity-specific summary odds ratios (ORs) and corresponding 95% confidence intervals (CIs) as risk estimates for IL-1 polymorphisms individually or in combination. Heterogeneity and publication bias were evaluated by Q-test, I2 statistic, Begg's funnel plot and Egger's test accordingly. The composite genotype of IL-1A (-889) and IL-1B (+3954) was associated with increased risk of implant failure/loss (OR 1.76, 95% CI 1.21-2.57) and peri-implantitis (OR 2.34, 95% CI 1.03-5.33). The significance was borderline in European descents (implant failure/loss: OR 1.48, 95% CI 0.99-2.22; peri-implantitis: OR 1.65, 95% CI 1.00-2.73). T allele of IL-1B (-511) was associated with increased risk of implant failure/loss (OR 1.28, 95% CI 1.01-1.62), while the association was not significant in European descents (OR 1.12, 95% CI 0.85-1.48). These findings support a potential role of IL-1 polymorphisms, particularly the composite genotype of IL-1A (-889) and IL-1B (+3954), in peri-implant disease susceptibility. More studies with large sample size are needed to validate the associations.

Susceptibility of different mouse strains to peri‐implantitis

“…Moreover, the current study concurs with other studies that identified the genetic importance of single nucleotide polymorphisms as a risk factor for PI . In addition, our data, in conjunction with previously published data, suggest that PI, like periodontitis, is a complex trait disease, in which multiple genetic polymorphisms act in concert to increase disease risk . Corroborating with a complex trait disease model for PI, a meta‐analysis evaluating the role of interleukin‐1 in PI showed that while there was not a significant effect of interleukin‐1A or interleukin‐1B individually, a composite polymorphism phenotype with interleukin‐1A and interleukin‐1B was associated with an increased risk for implant failure and subsequent PI …”

Association between tumor necrosis factor-alpha G-308A polymorphism and dental peri-implant disease risk

“…For example, Liao et al [37] performed a meta-analysis on the association between interleukin-1 polymorphisms and dental implant failure. They found that interleukin-1α (−899) and interleukin-1β (+3954) polymorphisms are among the risk factors of dental implant failure/loss and peri-implantitis.…”

Clinical aspects and polymorphisms in the LTA, TNFA, LTB genes and association with dental implant loss

“…Among these factors, the most studied are those related to the host, such as bone quantity and quality osteoporosis, smoking, presence of teeth plaque and calculus index, dental mobility general health condition and genetic factors . The suggestion, is that genetic background contributes to a better understanding of why some patients present dental implant failure without a clear clinical cause…”

“…Studies have already suggested a genetic contribution to dental implants loss. Losses without apparent clinical cause were attributed partially to genetic polymorphisms, which may influence the osseointegration process of dental implants . To the author's knowledge, there is no study with LTA , TNFA, and LTB genes and implant loss to date.…”

“…Independently on the type of loss, this condition presents a multifactorial characteristic . It was found that most patients who lost implant (75%) did not present any apparent clinical cause, and several studies have suggested the association of implant loss with genetic factors …”