Meta-analysis of the Association between HLA-DRB1 Allele and Rheumatoid Arthritis Susceptibility in Asian Populations

Abstract

The aims of this study were to summarize results on the association of HLA-DRB1 with rheumatoid arthritis (RA) in Asians and to determine if the shared epitope (SE) hypothesis could explain the meta-analysis results. Among the papers published between January 1987 and July 2006 on RA susceptibility in Asian-Mongoloid populations (Korean, Japanese, Chinese, and Thai), 12 were selected for the meta-analysis. Mongoloid-Asian patients with RA had significantly higher frequencies of HLA-DRB1*0101, *0401, *0410, and *1001 than controls (OR 1.5-2.1, p<0.05 for association). When analyses were restricted to more ethnically homogeneous populations, HLA-DRB1*0405 showed a significant susceptibility to RA in Koreans (OR 5.65, 95% CI 4.32-7.39), whereas the HLA-DRB1*0301, *0403, *0406, *0701, *1301, and *1405 alleles showed protective association with RA (OR 0.32-0.70, p<0.05 for association). In conclusion, it was found that HLA-DRB1 *0101, *0401, *0405, *0410, and *1001 are susceptible, while HLA-DRB1*0301, *0403, *0406, *0701, *1301, and *1405 are protective in Asian-Mongoloids. All the RA-associated alleles except DRB1*0301 could be explained by the structural model supporting the SE hypothesis that RA susceptibility is determined by the combination of amino acid residues at HLA-DR β71 and β74, not by β71 alone.

Frequency of HLA-DRB1 alleles in rheumatoid arthritis patients in Zahedan, southeast Iran

“…Other studies demonstrated association between these alleles and RA; they have recently been reviewed in a number of meta-analyses or review articles 1112. Consistent with the above results, we found DRB1*10 to be a predisposing factor in the studied population; however, in contrast, DRB1*01 allele was found to be equally distributed between RA and control groups.…”

“…Another meta-analysis, in Asian-Mongoloids (Korean, Japanese, Chinese and Thai), showed that HLA-DRB1*0101, *0401, *0405, *0410 and *1001 are contributory to susceptibility, while HLA-DRB1* 0301, *0403, *0406, *0701, *1301 and *1405 are protective 11. Like the results among Asian populations, the HLA-DRB1*03 was found in our study to play a protective role against RA.…”

Meta-Analysis of the Association of HLA-DRB1 with Anti-Citrullinated Protein Antibody-Positive and Anti-Citrullinated Protein Antibody-Negative Rheumatoid Arthritis

“…These results are in accordance with studies performed by Diane van der Woude [6] and Kyung Ran Jun [30]. Previous study has…”

Türkiye’nin Güneydoğu Anadolu Bölgesinde Tersiyer Bir Merkezdeki Romatoid Artritli Hastalarda HLAD-RB1 Alel Dağılımı

“…In a meta-analysis on the Asian population, the DRB1*0403, DRB1*0701, DRB1*1101 and DRB1*1405 subtypes were found as the protective alleles in patients with RA (17). In addition, in another study on RA patients in Korea, DRB1*0701 has been described as the protective subtype (7).…”

“…In a meta-analysis on the Asian population, the DRB1*1001 allele was shown to be more frequent in patients with RA compared to controls (17). In the Spanish (13) and Greek populations (14), the DRB1*1001 allele was found to be related with the predisposition to RA.…”