Meta-analysis of the antifungal activities of three essential oils as alternative therapies in dermatophytosis infections

Rodríguez, Julia Villar; Pico, Ana María Pérez; Álvarez, Esther; Mayordomo, Raquel

doi:10.1111/jam.15539

Cited by 11 publications

(4 citation statements)

References 91 publications

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“…Overall, we can summarize our findings that lemongrass and cinnamon have significantly better efficacy than tea tree, except for the concentration of 100 %, and their effect did not dependent on the tested concentration. The efficacy was the highest possible and the zone inhibition Despite promising results of recent studies [6,33,50], we agree with their authors that the potential toxicity of these products must be considered because EO have been shown to cause skin allergy and irritation. As a result, it is critical not only to investigate the effectiveness of essential oils, but also pay attention to their safety (harmlessness) as well as the potential associated risks.…”

Section: T a O Et Al Confirmed That Essential Oil Fromsupporting

confidence: 81%

In Vitro Antifungal Activity of Selected Essential Oils Against Trichophyton mentagrophytes

Kottferová¹,

Čonková

2023

Folia Veterinaria

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The in vitro activity of Cinnamomum cassia, Melaleuca alternifolia, and Cymbopogon citratus essential oils and antimycotics clotrimazole, fluconazole, and ketokonazole against T. mentagrophytes was evaluated by the disc-diffusion method. The essential oils were tested at 5, 10, 20, 30, 50, and 100 % concentration. It was found that Cymbopogon, commonly called lemongrass, and cinnamon show stable results independent of the concentration used, whereas the efficacy of tea tree oil, significantly decreases with the decreasing concentration. When comparing the efficacy of antimycotics the largest zone of inhibition was obtained with clotrimazole, while fluconazole proved to be ineffective. We found that cinnamon and lemongrass are more effective than the antimycotics that we have used. Our study confirmed that some essential oils can be used for the treatment of dermatophytoses caused by Trichophyton mentagrophytes and some of them are more effective than the commercial drugs.

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Section: T a O Et Al Confirmed That Essential Oil Fromsupporting

confidence: 81%

In Vitro Antifungal Activity of Selected Essential Oils Against Trichophyton mentagrophytes

Kottferová¹,

Čonková

2023

Folia Veterinaria

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“…The activities found were dose-dependent with significant cytotoxicity at concentrations of ≥10% [ 78 ]. Despite these results, a recent meta-analysis showed that TTO had a limited antifungal effect ( Trichophyton rubrum , Trichophyton mentagrophytes complex, and C. albicans ) when compared to other EOs ( Cinnamomum zeylanicum and Thymus vulgaris ) [ 79 ]. Thus, the use of TTO against dermatophytes would not be advisable.…”

Section: Biological Properties Of Ttomentioning

confidence: 99%

Tea Tree Oil: Properties and the Therapeutic Approach to Acne—A Review

et al. 2023

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Acne vulgaris is an inflammatory dermatological pathology that affects mostly young people. However, it can also appear in adulthood, mainly in women. It has a high psychosocial impact, not only at the time of active lesions but also due to the consequences of lesions such as scarring and hyperpigmentation. Several factors are involved in the physiopathology of acne and the constant search for active ingredients is a reality, namely phytotherapeutic ingredients. Tea tree oil is an essential oil extracted from Melaleuca alternifolia (Maiden & Betch) Cheel with known antibacterial, anti-inflammatory, and antioxidant properties, making it a candidate for the treatment of acne. This review aims to describe the various properties of tea tree oil that make it a possible ingredient to use in the treatment of acne and to present several human studies that have evaluated the efficacy and safety of using tea tree oil in the treatment of acne. It can be concluded that tea tree oil has good antibacterial, anti-inflammatory, and antioxidant properties that result in a decrease in the number of inflammatory lesions, mainly papules, and pustules. However, given the diversity of study designs, it is not possible to draw concrete conclusions on the efficacy and safety of this oil in the treatment of acne.

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“…The two major classes used are azole, topical drugs (i.e., tioconazole, clotrimazole, oxiconazole, econazole, miconazole) and systemic azole agents (fluconazole, itraconazole) and allylamine (terbinafine and naftifine) [ 150 ]. Promising results are obtained with alternative antifungal agents such as epigallocatechin 3-O-gallate (EGCg) [ 159 , 160 ] and plant essential oils [ 161 , 162 , 163 ].…”

Section: Fungal Infectionsmentioning

confidence: 99%

Clinical Manifestations of Human Exposure to Fungi

Oliveira

Lisboa

et al. 2023

JoF

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Biological particles, along with inorganic gaseous and particulate pollutants, constitute an ever-present component of the atmosphere and surfaces. Among these particles are fungal species colonizing almost all ecosystems, including the human body. Although inoffensive to most people, fungi can be responsible for several health problems, such as allergic fungal diseases and fungal infections. Worldwide fungal disease incidence is increasing, with new emerging fungal diseases appearing yearly. Reasons for this increase are the expansion of life expectancy, the number of immunocompromised patients (immunosuppressive treatments for transplantation, autoimmune diseases, and immunodeficiency diseases), the number of uncontrolled underlying conditions (e.g., diabetes mellitus), and the misusage of medication (e.g., corticosteroids and broad-spectrum antibiotics). Managing fungal diseases is challenging; only four classes of antifungal drugs are available, resistance to these drugs is increasing, and no vaccines have been approved. The present work reviews the implications of fungal particles in human health from allergic diseases (i.e., allergic bronchopulmonary aspergillosis, severe asthma with fungal sensitization, thunderstorm asthma, allergic fungal rhinosinusitis, and occupational lung diseases) to infections (i.e., superficial, subcutaneous, and systemic infections). Topics such as the etiological agent, risk factors, clinical manifestations, diagnosis, and treatment will be revised to improve the knowledge of this growing health concern.

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Meta-analysis of the antifungal activities of three essential oils as alternative therapies in dermatophytosis infections

Cited by 11 publications

References 91 publications

In Vitro Antifungal Activity of Selected Essential Oils Against Trichophyton mentagrophytes

In Vitro Antifungal Activity of Selected Essential Oils Against Trichophyton mentagrophytes

Tea Tree Oil: Properties and the Therapeutic Approach to Acne—A Review

Clinical Manifestations of Human Exposure to Fungi

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