Meta-Analysis of Risk Association Between Interleukin-17A and F Gene Polymorphisms and Inflammatory Diseases

Abstract

This meta-analysis examined the relationship between IL-17A (rs2275913) and IL17F (rs763780 T/C) gene polymorphisms and the risk of inflammatory diseases, including periodontitis, rheumatoid arthritis (RA), and inflammatory bowel disease. PubMed, MEDLINE, EMBASE, Web of Science, and Elsevier Science Direct were searched, and odds ratios (ORs) with 95% confidence interval (CI) were calculated to estimate the strength of the association. A total of 25 studies comprising 7,474 cases and 10,628 controls were included. Significant associations were found between inflammatory diseases and IL-17A rs2275913 A versus G allele (OR = 1.197, P = 0.033) and the GA versus GG genotype in the codominant model (OR = 1.406, P = 0.036). Our findings suggested that individuals who carry the rs2275913 A allele or GA genotype have a 20% or 41%-increased risk of inflammatory diseases compared with subjects with the G allele or GG genotype, respectively. With respect to IL-17F rs763780, the C versus T allele (OR = 1.94; P = 0.040), the TC versus TT (OR = 1.39; P = 0.041), the CC versus TT (OR = 2.71; P = 0.003), as well as the TC + CC versus TT genotype (OR = 1.83; P = 0.032) were risk factors for RA. In summary, our pooled analysis indicated that the IL-17A (rs2275913) and IL17F (rs763780 T/C) increased the RA risk.

Genetic variants in IL17A and serum levels of IL-17A are associated with COPD related to tobacco smoking and biomass burning

“…On the other hand, the Th17 profile has been studied widely in autoimmune diseases and has been described as a risk factor. For example, there are studies of SNPs in IL17A associated with rheumatoid arthritis and systemic lupus erythematosus [8][9][10][11] , but there are not enough studies in COPD, despite the pathophysiological role of IL17 and Th17 cells. Since 2003, Agustí and coworkers 12 hypothesized that one of the possible pathogenic mechanisms in COPD is the existence of self-perpetuating inflammation, similar to other autoimmune diseases.…”

Association of Interleukin-17F 7488A/G and 7383A/G Polymorphisms With Rheumatoid Arthritis: A Meta-Analysis

“…Another meta-analysis including four studies also observed a positive association between IL-17F 7488A/G and RA susceptibility. 30 However, caution should be taken for the conclusion of this meta-analysis since a study on osteoarthritis was included in the RA group. 31 There were several strengths of our work.…”

Correlation study between Interleukin-17 Gene Polymorphisms and risk of development of recurrent aphthous ulcer in Han Chinese Population

“…Currently, IL-17 was considered as one of pro-in ammatory cytokines, and IL-17 could initiate the release of pro-in ammation cytokines and chemokines, , matrix metalloproteinases, and antimicrobial peptides from myeloid cells, mesenchymal cells and even epithelial cells [11]. Recently, IL-17 has emerged as an important driver of pathogenic in ammation, and is considered a key underlying element in the pathogenesis of autoimmune diseases such as systemic lupus erythematosus, membranous glomerulonephritis, and others [12,13].…”