Meta‐analysis of randomized, controlled treatment trials for pediatric obsessive‐compulsive disorder

Watson, Hunna J.; Rees, Clare S.

doi:10.1111/j.1469-7610.2007.01875.x

Cited by 250 publications

(161 citation statements)

References 43 publications

(38 reference statements)

Supporting

Mentioning

146

Contrasting

Unclassified

Order By: Relevance

“…Finally, the length of treatment was consistent with other treatment studies of childhood OCD (Abramowitz et al, 2005;Watson and Rees, 2008). However, it may have been insufficient to observe an effect of riluzole.…”

Section: Discussionsupporting

confidence: 74%

“…It often causes significant morbidity and persists across the lifespan (Micali et al, 2010). Established treatments for childhood OCD include the serotonin reuptake inhibitors (SRIs) and cognitivebehavioral therapy (CBT), particularly exposure and response prevention (Geller et al, 2003;Watson and Rees, 2008). Moreover, the combination of medication and CBT may be more effective than either treatment alone (Pediatric OCD Treatment Study, 2004).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

12-Week, Placebo-Controlled Trial of Add-on Riluzole in the Treatment of Childhood-Onset Obsessive–Compulsive Disorder

Grant

Joseph

Farmer

et al. 2013

Neuropsychopharmacol

View full text Add to dashboard Cite

Many children with childhood-onset obsessive-compulsive disorder (OCD) fail to respond adequately to standard therapies. Evidence from preclinical and clinical studies suggests that the glutamatergic neurotransmitter system might be an alternative treatment target. This study examined the efficacy of riluzole, a glutamatergic modulator, as an adjunctive therapy for children with treatment-resistant OCD. In a 12-week, double-blind, placebo-controlled study, 60 treatment-resistant children and adolescents (mean age ¼ 14.5±2.4 years), with moderate to severe OCD (mean Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS) ¼ 28.2 ± 3.7), 17 of whom also had concomitant autism spectrum disorder, were randomized to receive riluzole (final dose of 100 mg/day) or placebo in addition to the existing treatment regimen. Fifty-nine subjects completed the randomized trial. Primary outcome measures were changes on the CY-BOCS, the Clinical Global Impressions Scale, and the Children's Global Assessment Scale. Riluzole was fairly well tolerated, although it was associated with one case of pancreatitis and five instances of slight increases in transaminases. All subjects showed significant reductions in CY-BOCS scores during treatment; however, there was no significant difference between placebo and riluzole on any of the primary or secondary outcome measures. The study failed to demonstrate superiority of riluzole over placebo as an adjunctive treatment for children with childhood-onset OCD. However, future studies may show benefits for less treatment-refractory children with fewer concomitant medications.

show abstract

Section: Discussionsupporting

confidence: 74%

Section: Introductionmentioning

confidence: 99%

12-Week, Placebo-Controlled Trial of Add-on Riluzole in the Treatment of Childhood-Onset Obsessive–Compulsive Disorder

Grant

Joseph

Farmer

et al. 2013

Neuropsychopharmacol

View full text Add to dashboard Cite

show abstract

“…In these two meta-analyses only psychological treatments were included. The overlap was even lower when compared our meta-analysis with other meta-analyses that also included pharmacological treatments, such as Watson and Rees (2008) with 6.5%, or Abramowitz et al (2005) with 19.6%. The minor overlap between our meta-analysis and the previous ones guarantees the originality of our results.…”

Section: Search Strategymentioning

confidence: 83%

“…There have been published four meta-analyses on the efficacy of psychological interventions in pediatric OCD (Abramowitz, Whiteside, & Deacon, 2005;Freeman et al, 2007;O'Kearney, 2007;Watson & Rees, 2008). Abramowitz et al (2005Abramowitz et al ( ) identified 18 articles, published between 1983Abramowitz et al ( and 2004, that included 10 ERP groups, 10 pharmacotherapy groups, and seven placebo control groups.…”

Section: Review Of Previous Meta-analysesmentioning

confidence: 99%

Psychological Treatment of Obsessive-Compulsive Disorder in Children and Adolescents: a Meta-Analysis

et al. 2015

View full text Add to dashboard Cite

Abstract. Although several meta-analyses have investigated the efficacy of psychological treatments for pediatric obsessive-compulsive disorder (OCD), there is not yet a consensus on the most efficacious treatment components. A meta-analysis was carried out to examine the efficacy of the different treatment techniques used in the psychological interventions of pediatric OCD. An exhaustive literature search from 1983 to February 2014 enabled us to locate 46 published articles that applied some kind of cognitive-behavioral therapy (CBT). For each group the effect size was the standardized pretest-posttest mean change, and it was calculated for obsessive-compulsive symptoms and for other outcome measures. The results clearly showed large effect sizes for CBT in reducing obsessive-compulsive symptoms and, to a lesser extent, other outcome measures (d + = 1.860; 95% CI: 1.639; 2.081). The most promising treatments are those based on multicomponent programs comprising ERP, cognitive strategies, and relapse prevention. The analysis of other potential moderator variables and the implications for clinical practice are discussed.

show abstract

“…A substantial number of studies have evaluated the use of cognitive-behavioural therapy (CBT) involving exposure and response prevention [6,31,32]. Interventions for OCD, as indeed as for other child psychiatric disorders, have also taken into increasing consideration the involvement of parents and families [28].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of quality of life therapy for parents of children with obsessive–compulsive disorders in Iran

Abedi

Vostanis

2010

Eur Child Adolesc Psychiatry

View full text Add to dashboard Cite

Previous research has provided evidence on the effectiveness of CBT in the symptomatic improvement of children with obsessive-compulsive disorders. There is also increasing recognition of the importance of involving parents and families in treatment. The aim of this study was to evaluate the short-term effectiveness of such an intervention that promoted family strengths [(quality of life therapy (QoLT)] for mothers of children with obsessivecompulsive disorders (OCD). The sample consisted of 40 children with OCD and their mothers, who had been referred to clinics in Esfahan city in Iran. Mothers were randomly allocated to an experimental (QoLT) and waiting list control group. Mothers participated in eight QoLT group sessions over 4 weeks. QoLT incorporated CBT techniques in managing OCD symptoms. Measures were completed pre-and post-intervention by both groups. Children completed the Yale-Brown obsession compulsion scale for Children, the Revised children's manifest anxiety scale, and the brief multidimensional student's life satisfaction scale; mothers completed the quality of life inventory (QoLI). QoLT was associated with decrease in OCD and anxiety symptoms and increase in children's satisfaction in the global, family and environment domains, as well as with increased QoLI scores in their mothers.Parenting interventions like QoLT can complement individual modalities such as CBT in the presence of familyrelated difficulties. This can be particularly applicable in countries and settings with limited resources and high stigma of child mental health problems.

show abstract

Meta‐analysis of randomized, controlled treatment trials for pediatric obsessive‐compulsive disorder

Cited by 250 publications

References 43 publications

12-Week, Placebo-Controlled Trial of Add-on Riluzole in the Treatment of Childhood-Onset Obsessive–Compulsive Disorder

12-Week, Placebo-Controlled Trial of Add-on Riluzole in the Treatment of Childhood-Onset Obsessive–Compulsive Disorder

Psychological Treatment of Obsessive-Compulsive Disorder in Children and Adolescents: a Meta-Analysis

Evaluation of quality of life therapy for parents of children with obsessive–compulsive disorders in Iran

Contact Info

Product

Resources

About