Meta-analysis of P300 waveform in panic disorder

Howe, Aaron; Pinto, Antônio Carlos Guedes; Luca, Vincenzo De

doi:10.1007/s00221-014-3999-5

Cited by 21 publications

(17 citation statements)

References 47 publications

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“…Although there was no significant frontal-greater-than-parietal P3b topography in the right hemisphere in the depression group or anxiety group, decreased parietal P3b and increased frontal P3b were observed for both patient groups. Decreased parietal P3b with regard to depression and anxiety is consistent with previous studies 21 23 24 25 35 36 . Increased frontal P3b in the anxiety group arose from increased PFC activities according to the source analysis results.…”

Section: Discussionsupporting

confidence: 92%

“…The results of the previous P300 studies of anxiety disorders have not suggested consistent patterns. Decreased parietal P3b in patients with anxiety disorders has been reported in a few studies 23 24 25 , whereas increased frontal P300 subcomponent has been found to be associated with anxiety disorders in one study 26 . Additionally, few studies have investigated P300 in comorbid patients.…”

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confidence: 83%

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Source analysis of P3a and P3b components to investigate interaction of depression and anxiety in attentional systems

Wang

Liu

et al. 2015

Sci Rep

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This study examined the impact of depressive disorders, anxiety disorders and the comorbidity of these disorders on the regional electrophysiological features of brain activity. Sixty-four-channel event-related potentials (ERP) were acquired during a visual oddball task in patients with depressive disorder, patients with anxiety disorders, patients with comorbid depressive and anxiety disorders and healthy subjects. An fMRI-constrained source model was applied to ERP to identify different cortical activities in the patient and control groups. Comorbid patients showed an abnormal frontal-greater-than-parietal P3b topography in the right hemisphere and the highest P3a amplitude at frontal and central sites at the scalp midline. For P3b, depressed patients showed decreased right-lateralized activity in the precentral sulcus (PrCS) and posterior parietal cortex (PPC). Anxious patients demonstrated hyperactive prefrontal cortices (PFC). Comorbid patients presented decreased activity in the cingulate gyrus, right PrCS and right PPC and increased activity in the left PFC and left insular (INS). For P3a, hyperactive left PrCS was found in comorbid patients. Comorbid patients showed both anxiety-related and depression-related activity. A superimposition effect of depression and anxiety was identified with (1) aggravated hypo-function of the right-lateralized dorsal attention and salience networks and (2) complicated anxiety-related hyper-function of the left-lateralized ventral attention and salience networks.

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Section: Discussionsupporting

confidence: 92%

mentioning

confidence: 83%

Source analysis of P3a and P3b components to investigate interaction of depression and anxiety in attentional systems

Wang

Liu

et al. 2015

Sci Rep

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“…So far, the underlying theoretical framework about P300 latency is still not well explained. Delayed P300 latency was found in patients with obvious cognitive impairment, such as schizophrenia [61,62], mild cognitive impairment [63], and Alzheimer's disease [63], but not in panic disorders [64] as well as ASD in this meta-analysis. As the synthetic effect sizes contained a significant level of heterogeneity, we conducted subgroup analysis to investigate the root causes and to test if there was difference between groups in each subgroup.…”

Section: Discussionmentioning

confidence: 95%

P300 amplitude and latency in autism spectrum disorder: a meta-analysis

Cui

Wang

Liu

et al. 2016

Eur Child Adolesc Psychiatry

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Autism spectrum disorder (ASD) is an early onset neurodevelopmental disorder. Evidence suggests that ASD patients have abnormalities in information processing. Event-related potential (ERP) technique can directly record brain neural activity in real time. P300 is a positive ERP component which can measure the neuroelectrophysiological characteristics of human beings and has the potential to discover the pathological mechanism of ASD. However, P300 studies on ASD patients are incongruent and the disparities may be caused by several factors. By searching PubMed, Embase and Cochrane Library databases, a meta-analysis of P300 component difference between ASD group and typically developed (TD) control group was conducted. Results of amplitude and latency of P3b and P3a from included studies were synthesized. Random effect model was chosen and standardized mean difference (SMD) was calculated. Subgroup analysis was used to identify the source of heterogeneity and to test the effect of different experiment factors. A total of 407 ASD patients and 457 TD controls from 32 studies were included in this analysis. Reduced amplitude of P3b was found in ASD group (SMD = -0.505, 95 % CI -0.873, -0.138) compared with TD group, but no difference of P3b latency, P3a amplitude, or P3a latency was found between groups. Subgroup analysis showed that oddball paradigm elicited attenuated P3b amplitude in Pz electrode among ASD subjects. This meta-analysis suggests ASD patients have abnormalities in P300 component, which may represent for deficits in cognition, attention orientation and working memory processing, particularly in the decision-making processing condition.

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“…To our knowledge, no previous study has examined the interaction between error processing and the P300 in relation to individual differences in anxiety. Some previous work has found an increased P300 in anxious individuals (Ischebeck, Endrass, Simon, & Kathmann, 2011;Miltner et al, 2005;Simons, 2010;Wang et al, 2013), while other work has not (Howe, Pinto, & De Luca, 2014;Kıvırcık, Yener, Alptekin, & Aydın, 2003;Sachs et al, 2004). To our knowledge, no previous study has examined the relationship between the P300 elicited by flanker stimuli and anxiety; most studies have focused on the P300 in response to emotional stimuli (e.g., images of spiders in spider phobics).…”

Section: Discussionmentioning

confidence: 98%

Considering ERP difference scores as individual difference measures: Issues with subtraction and alternative approaches

et al. 2016

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There is growing interest in psychophysiological and neural correlates of psychopathology, personality, and other individual differences. Many studies correlate a criterion individual difference variable (e.g., anxiety) with a psychophysiological measurement derived by subtracting scores taken from two within-subject conditions. These subtraction-based difference scores are intended to increase specificity by isolating variability of interest. Using data on the error-related negativity (ERN) and correct response negativity (CRN) in relation to generalized anxiety disorder (GAD), we highlight several conceptual and practical issues with subtraction-based difference scores and propose alternative approaches based on regression. We show that ERN and CRN are highly correlated, and that the DERN (i.e., ERN 2 CRN) is correlated in opposite directions both with ERN and CRN. Bivariate analyses indicate that GAD is related to DERN and ERN, but not CRN. We first show that, by using residualized scores, GAD relates both to a larger ERN and smaller CRN. Moreover, by probing the interaction of ERN and CRN, we show that the relationship between GAD and ERN varies by CRN. These latter findings are not evident when using traditional subtraction-based difference scores. We then completed follow-up analyses that suggested that an increased P300 in anxious individuals gave rise to the apparent anxiety/CRN relationship observed. These findings have important conceptual implications for facilitating the interpretability of results from individual difference studies of psychophysiology.

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Meta-analysis of P300 waveform in panic disorder

Cited by 21 publications

References 47 publications

Source analysis of P3a and P3b components to investigate interaction of depression and anxiety in attentional systems

Source analysis of P3a and P3b components to investigate interaction of depression and anxiety in attentional systems

P300 amplitude and latency in autism spectrum disorder: a meta-analysis

Considering ERP difference scores as individual difference measures: Issues with subtraction and alternative approaches

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