Meta-analysis of latent tuberculosis in healthcare workers in Iran: a retrospective review

Abstract

Background Here we review the status of latent tuberculosis (LTB) in Iranian healthcare workers (HCWs). Methods A literature search was conducted using keywords according to the Preferred Reporting Items for Systematic Review and Meta-Analyses instructions. Cross-sectional studies published from 1 January 2000 through 1 January 2019 were retrieved. Meta-analysis was performed using Comprehensive Meta-Analysis software using the random effects model, Cochran's Q and I2 tests. Publication bias was estimated by funnel plot and Egger's linear regression test. Results Among 774 articles retrieved in the primary literature search, 21 studies met the eligibility criteria. No publication bias was observed among the included studies (p=0.07). The prevalence of LTB ranged from 7% to 63% in Iranian HCWs from different geographical areas. The overall combined prevalence of LTB among Iranian HCWs was 30.9% (95% confidence interval 24.2 to 38.5). Also, 52.4% of the included studies showed a significant correlation between occupation and LTB incidence (p<0.05). Conclusions The prevalence of LTB was high among Iranian HCWs. This requires developing comprehensive information databases and surveillance systems for detecting LTB among HCWs. It is also essential to periodically screen for LTB in HCWs to provide a timely diagnosis of the infection. It is recommended to perform a tuberculin skin test, a useful tool for screening and treatment of LTB, on an annual basis in HCWs.

Changes in the rate of bacillus tuberculosis infection in health workers in the first year of the COVID-19 epidemic in Kashan- Iran

“…The prevalence in EMRO member countries in 2021 was 41.78% [ 22 ], while among medical personnel in low- and middle-income countries, it was 54% [ 23 ]. The prevalence of LTBI among medical personnel in various regions of Iran has ranged from 7% to 63% [ 24 , 25 ]. In the Doosti study conducted in Iran, Golestan province exhibited the highest incidence rate of new TB cases at 35.9 per 100,000, followed closely by Sistan and Baluchestan with a rate of 34.2 per 100,000.…”