Meta-analysis of IL12B polymorphisms (rs3212227, rs6887695) with psoriasis and psoriatic arthritis

Abstract

Interleukin 12 (IL-12) is a key player in model systems of autoimmunity. One of the most robust genetic findings is the association of variants in the IL12B gene with psoriasis and psoriatic arthritis (PsA). This study aims to assess whether combined evidence shows the association between IL12B polymorphisms and the susceptibility to psoriasis/PsA. We conducted a systematic review to examine the association between the IL12B rs3212227 (1188A > C) and rs6887695 and psoriasis/PsA. In addition, we used studies for which combined information from all genotypes was available to compare risks in dominant and recessive model. Potential publication bias was evaluated by Egger's linear regression test. Eleven articles met the inclusion criteria and contributed data to the meta-analyses. For rs3212227, the odds ratios the minor allele for psoriasis and PsA were 0.688 (95 % CI 0.650-0.729) and 0.707 (95 % CI 0.628-0.797), respectively. Then, for rs6887695, the pooled ORs were 0.704 (95 % CI 0.670-0.739) for psoriasis and 0.677 (95 % CI 0.599-0.767) for PsA. The overall ORs for all genotypes of rs3212227 and rs6887695 were all significantly associated with psoriasis. No publication bias was presented. Taken together, our results demonstrate a significant association between IL12B gene polymorphisms and psoriasis and PsA.

New polymorphisms associated with response to anti-TNF drugs in patients with moderate-to-severe plaque psoriasis

“…IL12 is a proinflammatory cytokine involved in the lymphocyte T helper 1 (Th1) pathway. This cytokine has been widely associated with psoriasis [28][29][30] . Moreover, rs2546890 in IL12 has been associated with psoriasis 26 .…”

IL12B (p40) Gene Polymorphisms Contribute to Ustekinumab Response Prediction in Psoriasis

“…Recent studies have highlighted the involvement of Th17 and underlined the crucial role of IL12 and IL23 in the context of Th17 cell-dependent chronic inflammation [3,11,12,13,14,15]. Psoriasis predisposition polymorphisms in the IL12B gene, encoding for the p40 subunit of IL-12 and IL-23, regulate the amount of p40 produced by cells in response to inflammatory stimuli and the polarization of Th cells in psoriasis [16].…”

Polymorphisms Associated with Adalimumab and Infliximab Response in Moderate-To-Severe Plaque Psoriasis

“…IL-12B is a proinflammatory cytokine that induces T helper 1 (Th1) pathway. Previous publications have suggested that IL-12B plays an important role in psoriasis development [12,44,45]. Furthermore, rs2546890 (IL-12B) is associated with the susceptibility to develop psoriasis [46] and to develop psoriatic arthritis in psoriasis patients [47].…”