Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder

Liu, Y; Blackwood, Douglas; Caesar, Sian; Geus, E.J.C. de; Farmer, Anne; Ferreira, Manuel; Ferrier, I. Nicol; Fraser, Christine; Gordon‐Smith, Katherine; Green, E K; Grozeva, Detelina; Gurling, Hugh; Hamshere, Marian L.; Heutink, Peter; Holmans, Peter; Hoogendijk, Witte J.G.; Hottenga, Jouke‐Jan; Jones, Lisa; Jones, Ian; Kirov, George; Lin, Dan; McGuffin, Peter; Moskvina, Valentina; Nolen, Willem A.; Perlis, Roy H.; Posthuma, Daniëlle; Scolnick, Edward M.; Smit, August B.; Smit, Jan; Smoller, Jordan W.; Clair, David St; Dyck, Richard van; Verhage, Matthijs; Willemsen, Gonneke; Young, Allan H.; Zandbelt, T.; Boomsma, Dorret I.; Craddock, Nick; O’Donovan, Michael; Owen, Michael John; Penninx, Brenda W. J. H.; Purcell, Shaun; Sklar, Pamela; Sullivan, Patrick F.

doi:10.1038/mp.2009.107

Cited by 163 publications

(140 citation statements)

References 14 publications

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“…Moreover, CACNA1C was involved in four of the top 10 pathways identified by both core-gene enrichment analysis and GWAS PBA (Table S3 in Supplement 1). This gene has been identified as associated with BD in several GWAS (37)(38)(39), and evidence from brain imaging has also demonstrated changes in total gray matter volume in carriers of risk allele (64). The pathways, in which CACNA1C was highly involved, might present possible explanations for this gene on its role in disease pathogenesis.…”

Section: Discussionmentioning

confidence: 94%

BDgene: A Genetic Database for Bipolar Disorder and Its Overlap With Schizophrenia and Major Depressive Disorder

Chang¹,

Gao²,

Zhao³

et al. 2013

Biological Psychiatry

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Section: Discussionmentioning

confidence: 94%

BDgene: A Genetic Database for Bipolar Disorder and Its Overlap With Schizophrenia and Major Depressive Disorder

Chang¹,

Gao²,

Zhao³

et al. 2013

Biological Psychiatry

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“…The gene product of DCAF12, DDB1 , and CUL4 associated factor 12 interacts with the COP9 signalosome, a macromolecular complex that interacts with cullin-RING E3 ligases and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. The locus 6q25.2 containing RGS17 was previously reported to be associated with major depressive and bipolar disorders (Ferreira et al 2008; Liu et al 2011), general cognitive ability (Davis et al 2010), and tonometry (Levy et al 2007). …”

Section: Discussionmentioning

confidence: 99%

Large-scale genome-wide association study of Asian population reveals genetic factors in FRMD4A and other loci influencing smoking initiation and nicotine dependence

et al. 2011

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Diseases related to smoking are the second leading cause of death in the world. Cigarette smoking is a risk factor for several diseases such as cancer and cardiovascular and respiratory disorders. Despite increasing evidence of genetic determination, the susceptibility genes and loci underlying various aspects of smoking behavior are largely unknown. Moreover, almost all reported genome-wide association studies (GWASs) have been performed on samples of European origin, limiting the applicability of the results to other ethnic populations. In this first GWAS on smoking behavior in an Asian population, after analyzing 8,842 DNA samples from the Korea Association Resource project with 352,228 single nucleotide polymorphisms (SNPs) genotyped for each sample, we identified 8 SNPs significantly associated with smoking initiation (SI) and 4 with nicotine dependence (ND). Because of the current unavailability of an independent Asian smoking sample, we replicated the discoveries in independent samples of European-American and African-American origin. Of the 12 SNPs examined in the replicated samples, we identified two SNPs, in the regulator of G-protein signaling 17 gene (rs7747583, p valuemeta = 6.40 × 10−6; rs2349433, p valuemeta = 5.57 × 10−6), associated with SI. Also, we found two SNPs significantly associated with ND; one in the FERM domain containing 4A (rs4424567, p valuemeta = 2.30 × 10−6) and the other at 7q31.1 (rs848353, p valuemeta = 9.16 × 10−8). These SNPs represent novel targets for examination of smoking behavior and warrant further investigation using independent samples.

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“…Serious mental disorders are currently diagnosed and differentiated based on clinical symptoms, yet the genetic aetiology of these disorders is a topic of active debate. Genetic association and genome-wide association studies (GWAS) (Huang et al, 2010;Liu et al, 2011;Purcell et al, 2009;Smoller et al, 2013) suggest there is some degree of genetic overlap among specific disorders such as affective disorders and psychosis, but also specific genetic diversity. Genetic pleiotrophy, or the impact of one gene on multiple phenotypes, has been reported to account for 17% of the genes or 5% of the single nucleotide polymorphisms (SNPs) associated with complex traits (Serretti and Fabbri, 2013;Sivakumaran et al, 2011).…”

Section: Introductionmentioning

confidence: 97%

Specific and common genes implicated across major mental disorders: A review of meta-analysis studies

Gatt

Burton

Williams

et al. 2015

Journal of Psychiatric Research

250

181

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Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder

Cited by 163 publications

References 14 publications

BDgene: A Genetic Database for Bipolar Disorder and Its Overlap With Schizophrenia and Major Depressive Disorder

BDgene: A Genetic Database for Bipolar Disorder and Its Overlap With Schizophrenia and Major Depressive Disorder

Large-scale genome-wide association study of Asian population reveals genetic factors in FRMD4A and other loci influencing smoking initiation and nicotine dependence

Specific and common genes implicated across major mental disorders: A review of meta-analysis studies

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