Meta-Analysis of Gene Expression Changes in the Blood of Patients with Mild Cognitive Impairment and Alzheimer’s Disease Dementia

Bottero, Virginie; Potashkin, Judith A.

doi:10.3390/ijms20215403

Cited by 33 publications

(24 citation statements)

References 161 publications

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“…This observation indicates that PEMF coupled with chemotherapy (TMZ plus PEMF) can trigger epigenetic mechanisms to slow down the neoplastic proliferation. Capelli et al (2017) focused on miR-335-5p and miR-26b-5p, which are upregulated in AD disorder (Bottero and Potashkin 2019). They applied an ex vivo model: peripheral blood mononuclear cells (PBMCs) freshly isolated from the peripheral blood of AD patients were exposed to PEMF (75 Hz, 3 mT) and, after exposure, miR levels were evaluated.…”

Section: Investigations On Brain Cellsmentioning

confidence: 99%

Epigenetic dysregulation in various types of cells exposed to extremely low-frequency magnetic fields

Giorgi

2021

Cell Tissue Res

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Epigenetic mechanisms regulate gene expression, without changing the DNA sequence, and establish cell-type-specific temporal and spatial expression patterns. Alterations of epigenetic marks have been observed in several pathological conditions, including cancer and neurological disorders. Emerging evidence indicates that a variety of environmental factors may cause epigenetic alterations and eventually influence disease risks. Humans are increasingly exposed to extremely low-frequency magnetic fields (ELF-MFs), which in 2002 were classified as possible carcinogens by the International Agency for Research on Cancer. This review summarizes the current knowledge of the link between the exposure to ELF-MFs and epigenetic alterations in various cell types. In spite of the limited number of publications, available evidence indicates that ELF-MF exposure can be associated with epigenetic changes, including DNA methylation, modifications of histones and microRNA expression. Further research is needed to investigate the molecular mechanisms underlying the observed phenomena.

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Section: Investigations On Brain Cellsmentioning

confidence: 99%

Epigenetic dysregulation in various types of cells exposed to extremely low-frequency magnetic fields

Giorgi

2021

Cell Tissue Res

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“…Indeed, there is no fully validated biomarker with the required sensitivity and specificity for accurately diagnosing patients within the dementia spectrum. Network-based approaches have been useful for revealing some of the mechanistic pathways involved in the development of different dementias including, AD [10][11][12][13][14], VaD [15], and FTD [16][17][18]. Very few studies, however, have employed network-based approaches for identifying unique features that could help distinguishing dementias.…”

Section: Introductionmentioning

confidence: 99%

Transcriptomic and Network Analysis Identifies Shared and Unique Pathways across Dementia Spectrum Disorders

Santiago¹,

Bottero

Potashkin

2020

IJMS

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Background: Dementia is a growing public health concern with an estimated prevalence of 50 million people worldwide. Alzheimer’s disease (AD) and vascular and frontotemporal dementias (VaD, FTD), share many clinical, genetical, and pathological features making the diagnosis difficult. Methods: In this study, we compared the transcriptome from the frontal cortex of patients with AD, VaD, and FTD to identify dysregulated pathways. Results: Upregulated genes in AD were enriched in adherens and tight junctions, mitogen-activated protein kinase, and phosphatidylinositol 3-kinase and protein kinase B/Akt signaling pathways, whereas downregulated genes associated with calcium signaling. Upregulated genes in VaD were centered on infectious diseases and nuclear factor kappa beta signaling, whereas downregulated genes are involved in biosynthesis of amino acids and the pentose phosphate pathway. Upregulated genes in FTD were associated with ECM receptor interactions and the lysosome, whereas downregulated genes were involved in glutamatergic synapse and MAPK signaling. The transcription factor KFL4 was shared among the 3 types of dementia. Conclusions: Collectively, we identified similarities and differences in dysregulated pathways and transcription factors among the dementias. The shared pathways and transcription factors may indicate a potential common etiology, whereas the differences may be useful for distinguishing dementias.

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“…Again, in another study an association of the same miRNA with PD specific genetic pathway was revealed [99]. A meta-analysis study also revealed hsa-miR-193b-3p to be dysregulated in patients with both mild cognitive impairment (MCI) and Alzheimer's Disease Dementia (ADD) [100]. hsa-miR-16-5p was also found to be deregulated (down-regulated) in several studies, in brain tissues of patients with Late-onset Alzheimer's Disease (LOAD) [101].…”

Section: Discussionmentioning

confidence: 95%

Identification of Common Molecular Signatures Shared between Alzheimer’s and Parkinson’s Diseases and Therapeutic Agents Exploration: An Integrated Genomics Approach

Faruqui

Prium

Mowna

et al. 2021

Preprint

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Alzheimer’s disease (AD) and Parkinson’s disease (PD) are two most prevalent age-related dementias that severely affect a large number of elderly people around the globe. Poor understanding of pathogenesis of these neurological diseases imposes challenge to discover therapeutic measures and effective diagnosis methods. In this study, a network-based approach was utilized to identify potential common molecular signatures and therapeutic agents for AD and PD. Protein-protein interaction analysis revealed NCK1, UBC, CDH1, CDC20, ACTB, PSMA7, PRPF8, RPL7, XRCC6 and HSP90AB1 as the best proteome signatures. Different regulatory transcriptional signatures i.e., YY1, NFKB1, BRCA1, TP53, GATA2, SREBF2, E2F1, FOXC1, RELA and NFIC and post-transcriptional signatures i.e., hsa-mir-186-5p, hsamir-92a-3p, hsa-mir-615-3p, hsa-let-7c-5p, hsa-mir-100-5p, hsa-mir-93-3p, hsa-mir-5681a, hsamir-484, hsa-mir-193b-3p and hsa-mir-16p-5p were identified from other interaction network. Drug-gene interaction study revealed possible therapeutic agents which may reverse the AD and PD condition. The scientific approach of this study should contribute to identify potential biomarkers, drug targets and therapeutic agents against AD and PD which should in turn advance the present efforts of scientists to secure effective diagnosis and therapeutic options. However, further in vivo and in vitro experiments might be required to validate the outcomes of this study.

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Meta-Analysis of Gene Expression Changes in the Blood of Patients with Mild Cognitive Impairment and Alzheimer’s Disease Dementia

Cited by 33 publications

References 161 publications

Epigenetic dysregulation in various types of cells exposed to extremely low-frequency magnetic fields

Epigenetic dysregulation in various types of cells exposed to extremely low-frequency magnetic fields

Transcriptomic and Network Analysis Identifies Shared and Unique Pathways across Dementia Spectrum Disorders

Identification of Common Molecular Signatures Shared between Alzheimer’s and Parkinson’s Diseases and Therapeutic Agents Exploration: An Integrated Genomics Approach

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