Meta-analysis of erythrocyte Na,K-ATPase activity in bipolar illness

Abstract

Sodium, potassium‐activated adenosine triphosphatase (Na,K‐ATPase) pump activity has been variously reported to be increased, decreased, or unchanged in bipolar patients. To explore this association we conducted a meta‐analysis of the available literature. All papers containing data on erythrocyte Na,K‐ATPase activity were reviewed independently by both authors. A meta‐analysis of these data was accomplished by standard procedure. We found a significant mood‐state‐related decrease in Na,K‐ATPase activity in both manic and bipolar depressed patients when compared to euthymic bipolar patients, but not when ill patients were compared to normal controls. The overall change can be characterized as small to moderate in magnitude. Depression and Anxiety 5:53–65, 1997. © 1997 Wiley‐Liss, Inc

The behavioral actions of lithium in rodent models: Leads to develop novel therapeutics

“…Although its precise relationship to the disorder is unknown, a finding in patients with bipolar disorder is dysregulated ion balance, as seen by increased intracellular sodium and calcium, and decreased sodium pump activity in peripheral cells (Looney and el-Mallakh, 1997). In order to investigate this relationship vis-à-vis rodent behavior, some investigators have administered ouabain, a sodium pump inhibitor, to rats.…”

Mania-like behavior induced by genetic dysfunction of the neuron-specific Na + ,K + -ATPase α3 sodium pump

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Psychiatric disorders in rapid-onset dystonia-parkinsonism

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