Meta-analysis of dragon’s blood resin extract as radio-protective agent

Mahmood, S. Z.; Fatima, Toseef; Zulfaqar, Hina; Saher, Romana; Rafiq, Muhammad; Rehman, Abdul; Dai, Ruitong; Ashfaq, Muhammad; Hasan, Murtaza

doi:10.12980/jclm.5.2017j7-75

Cited by 7 publications

(5 citation statements)

References 61 publications

(71 reference statements)

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Section: Resultsmentioning

confidence: 99%

“…Furthermore 70% hexane/H 2 O showed a much lower peak with no bio-reducing potential [36,37] ( Figure 2b). Similarly, the four methanol/hexane-based fractions with different ratios (30%, 50%, 70%, 90%) were evaluated next for bioreducing potential and was indicated that 30% fraction mixture of methanol/hexane (3:1) showed a much sharper peak indicating better bioreducing potential than 50%, 70%, 90% methanol/hexane fraction mixtures [23,38] (Figure 2c). For optimizing the results a comparative analysis was done between 30% fraction of methanol/H2O, 30% hexane/H2O and 30% methanol/hexane and the results demonstrated that out of all mixtures the 30% methanol/hexane (3:7) fraction mixture showed a much sharper peak.…”

Section: Characterization Of Green Synthesized Co 3 O 4 Npsmentioning

confidence: 98%

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Fractionation of Biomolecules in Withania coagulans Extract for Bioreductive Nanoparticle Synthesis, Antifungal and Biofilm Activity

et al. 2020

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Withania coagulans contains a complex mixture of various bioactive compounds. In order to reduce the complexity of the plant extract to purify its phytochemical biomolecules, a novel fractionation strategy using different solvent combination ratios was applied to isolate twelve bioactive fractions. These fractions were tested for activity in the biogenic synthesis of cobalt oxide nanoparticles, biofilm and antifungal activities. The results revealed that plant extract with bioactive fractions in 30% ratio for all solvent combinations showed more potent bioreducing power, according to the observed color changes and the appearance of representative absorption peaks at 500–510 nm in the UV-visible spectra which confirm the synthesis of cobalt oxide nanoparticles (Co3O4 NPs). XRD diffraction was used to define the crystal structure, size and phase composition of the products. The fractions obtained using 90% methanol/hexane and 30% methanol/hexane showed more effectiveness against biofilm formation by Pseudomonas aeruginosa and Staphylococcus aureus so these fractions could potentially be used to treat bacterial infections. The 90% hexane/H2O fraction showed excellent antifungal activity against Aspergillus niger and Candida albicans, while the 70% methanol/hexane fraction showed good antifungal activity for C. albicans, so these fractions are potentially useful for the treatment of various fungal infections. On the whole it was concluded that fractionation based on effective combinations of methanol/hexane was useful to investigate and study bioactive compounds, and the active compounds from these fractions may be further purified and tested in various clinical trials.

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Section: Resultsmentioning

confidence: 99%

Section: Characterization Of Green Synthesized Co 3 O 4 Npsmentioning

confidence: 98%

Fractionation of Biomolecules in Withania coagulans Extract for Bioreductive Nanoparticle Synthesis, Antifungal and Biofilm Activity

et al. 2020

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“…Dragon's blood (DB, Long-Xue in Chinese) is a rare and precious traditional medicine in China. It is abundant in four different plant genera: Dracaena, Croton, Daemonorops, and Pterocarpus ( 67 ). DB has the properties of anti-inflammation and anti-oxidative stress ( 68 ).…”

Section: Active Extracts Of Chinese Medicinesmentioning

confidence: 99%

The PI3K/AKT Pathway—The Potential Key Mechanisms of Traditional Chinese Medicine for Stroke

Zhang

et al. 2022

Front. Med.

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Stroke is associated with a high disability and fatality rate, and adversely affects the quality of life of patients and their families. Traditional Chinese Medicine (TCM) has been used effectively in the treatment of stroke for more than 2000 years in China and surrounding countries and regions, and over the years, this field has gleaned extensive clinical treatment experience. The Phosphatidylinositol 3 kinase (PI3K)/protein kinase B (AKT) pathway is important for regulation of cell migration, proliferation, differentiation, and apoptosis, and plays a vital role in vascularization and oxidative stress in stroke. Current Western medicine treatment protocols for stroke include mainly pharmacologic or mechanical thrombectomy to restore blood flow. This review collates recent advances in the past 5 years in the TCM treatment of stroke involving the PI3K/AKT pathway. TCM treatment significantly reduces neuronal damage, inhibits cell apoptosis, and delays progression of stroke via various PI3K/AKT-mediated downstream pathways. In the future, TCM can provide new perspectives and directions for exploring the key factors, and effective activators or inhibitors that affect occurrence and progression of stroke, thereby facilitating treatment.

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“…The previous study mentioned that this resin can be potentially used as a wound healing [2]. A recent study reveals that the phenolic compound in dragon blood resin can potentially act as protective agent in liver, brain, kidney failure, spleen, cerebrum diseases, antioxidant agent and anti-biofilm agent [3][4][5]. In Indonesia, this resin traditionally used for treatment of diarrhea, digestive problems, and wound healing.…”

Section: Introductionmentioning

confidence: 99%

“…Dragon's blood resin also reported contains few secondary metabolites such as Flavonoid, Terpenoid, and Tannin [9]. Dragon's blood resin is a bright red resin due to presence of flavylium chromophores also called Dracorhodin, which has ethnomedicinal properties because it contains phenolic compounds [3]. Toriq also reported that Dracorhodin is a major compound contain in dragon's blood resin.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Activity of n-Hexane Dragon’s Blood Resin Extract (Daemonorops draco wild Blume) from Bener Meriah, Aceh Province, Indonesia

et al. 2023

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The dragon’s blood resin (Daemonorops draco wild Blume) has been used in folk medicine for pharmacological activities such as antimicrobial, antivirus, anti-inflammation, gastrointestinal disorders, blood circulation dysfunctions, antitumor, and cancer. This study was designated to evaluate the antibacterial activity of n-Hexane dragon’s blood resin extract against Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, and Candida albicans 10231. The other purpose of this study was to determine the secondary metabolites compound of n-Hexane dragon’s blood resin extract. The antimicrobial activities of the n-Hexane dragon’s blood resin extract was determined using well diffusion method and the results showed that the extract at concentration of 15% exhibited antimicrobial activities against Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, and Candida albicans 10231 with the diameter inhibition of 13.20 mm; 21.3 mm; and 13.0 mm respectively. The phytochemicals screening showed that the extract contains secondary metabolites in the form of flavonoids. The GC-MS analysis showed that n-Hexane dragon’s blood resin extract contains 48 chemicals compounds, and the compound at RT 26 was indicated a Drachorhodin compound (C17H 18O3) with the mass ration of m/z was 270 g/mol. Overall, the n-Hexane dragon’s blood resin extract be a good choice for antimicrobial agent against bacteria and fungi.

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Meta-analysis of dragon’s blood resin extract as radio-protective agent

Cited by 7 publications

References 61 publications

Fractionation of Biomolecules in Withania coagulans Extract for Bioreductive Nanoparticle Synthesis, Antifungal and Biofilm Activity

Fractionation of Biomolecules in Withania coagulans Extract for Bioreductive Nanoparticle Synthesis, Antifungal and Biofilm Activity

The PI3K/AKT Pathway—The Potential Key Mechanisms of Traditional Chinese Medicine for Stroke

Antibacterial Activity of n-Hexane Dragon’s Blood Resin Extract (Daemonorops draco wild Blume) from Bener Meriah, Aceh Province, Indonesia

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