Meta-Analysis of Deferral Versus Performance of Coronary Intervention Based on Coronary Pressure–Derived Fractional Flow Reserve

Safety and Long-Term Clinical Outcomes of Fractional Flow Reserve Guided Coronary Revascularisation

“…Interestingly, on long-term follow-up, we found that patients with an FFR.0.80 were significantly more likely to suffer MACE than patients with an FFR0.80, the primary driver being a higher incidence of TVR (12.9% versus 5.3%). Early reports using bare metal stents to treat patients with FFR,0.80 found there was a 17% incidence [14] of TVR at 18 months but more recent studies employing second generation drug eluting stents have demonstrated very low rates of 3.7% at 3 years [5]. Prior investigators have found lower rates (2-8%) of TVR in patients with an FFR.0.80 where PCI was deferred in comparison with our study (12.9%) [12,14].…”

“…Early reports using bare metal stents to treat patients with FFR,0.80 found there was a 17% incidence [14] of TVR at 18 months but more recent studies employing second generation drug eluting stents have demonstrated very low rates of 3.7% at 3 years [5]. Prior investigators have found lower rates (2-8%) of TVR in patients with an FFR.0.80 where PCI was deferred in comparison with our study (12.9%) [12,14]. A potential explanation is that these studies only followed up patients for 2 to 3 years whereas our study followed up patients for up to 5 years.…”

Use and Value of Fractional Flow Reserve in Coronary Arteriography

“…15 In addition, the available literature confirms the safety of deferring PCI in FFR-negative lesions. 16…”

Transatlantic Editorial: a comparison between European and North American guidelines on myocardial revascularization

“…The American and European scientific societies recognize the prognostic importance of the severity of target vessel stenosis for radial graft patency based on visual assessment by coronary angiogram. Physiologically rather than anatomically defined stenosis as assessed by fractional flow reserve (FFR) has prognostic importance in percutaneous revascularization, and both the American and European guidelines recommend this practice for PCI [27][28][29][30][31][32]. There is some evidence that FFR-guided coronary surgery is associated with improved graft patency [33,34].…”