Meta-analysis of correlationship between HLA-G 3′UTR 14-bp Ins/Del polymorphism and virus susceptibility

Abstract

Background:There is a considerable amount of literature on the potential relationship between human leukocyte antigen-G 14-bp Ins/Del polymorphism and virus infection; however, results from these studies were inconclusive.Objectives:A meta-analysis was carried out to determine whether the 14-bp Ins/Del polymorphism is a susceptible factor for virus infection.Methods:Data were extracted from PubMed and Web of Science databases, and included 10 case–control studies (1835 patients and 2357 controls).Results:A total of 177 records from 10 studies were retrieved. Overall, no significant correlation was found between HLA-G 14-bp Ins/Del polymorphism and total viruses under all genetic models (dominant model: OR = 0.93, 95% CI = 0.68–1.29; recessive model: OR = 1.12, 95% CI = 0.84–1.48; deletion/deletion (DD) vs insertion/insertion (II): OR = 1.03, 95% CI = 0.71–1.49; deletion (D) vs insertion (I): OR = 1.01, 95% CI = 0.81–1.25). However, further subgroup analyses by virus type and ethnicity revealed that HLA-G 14-bp Ins/Del polymorphism was significantly associated with HTLV-1 infection in mixed population under the dominant model.Conclusions:Our study demonstrated that HLA-G 14-bp Ins/Del polymorphism may not have any effect on susceptibility to viruses.

HLA-G 14-bp insertion/deletion polymorphism and risk of coronavirus disease 2019 (COVID-19) among Iraqi patients

“…Some investigator groups have linked this polymorphism with human cytomegalovirus and human T-lymphotropic virus type-1 (HTLV-1) infections [27] , [44] , while others indicated no clear association with viral infections [25] , [45] . However, a meta-analysis study of 10 studies revealed that the overall analysis favored no association between different viral infections and the 14-bp Ins/Del polymorphism, but subgroup analysis demonstrated a significant association with HTLV-1 infection [46] . An additional study has demonstrated that HLΑ-G 14-bp Ins/Del polymorphism was significantly linked to chronic hepatitis B virus in Brazilians [26] .…”

HLA‐G: Function, polymorphisms and pathology

“…Thus, the 14‐bp DEL allele and INS/DEL genotype were more frequent in control group than in CHB patients (Eskandari et al, 2017). Yet, not all published results readily support the association between HLA‐G alleles and virus infection susceptibility and several reports (including meta‐analysis) question this linkage (Alves et al., 2015; Lv et al, 2018).…”

Evaluation of the Impact of Hla-G 14bp Polymorphism on the Susceptibility of Hepatitis C Virus Infection in Egyptian Patients

“…On the other hand, in a meta-analysis study, Lv et al (2018) demonstrated that HLA-G 14-bp Ins/Del polymorphisms may exert no influence on susceptibility to viruses. However, they added that, due to the limited number of studies examined, the results from that meta-analysis may be inconclusive.…”