Meta-Analysis of Clinical Efficacy of Pulsed Radio Frequency Energy Treatment

Guo, Lifei; Kubat, Nicole J.; Nelson, Teresa; Isenberg, Richard A.

doi:10.1097/sla.0b013e3182447b5d

Cited by 48 publications

(37 citation statements)

References 24 publications

(28 reference statements)

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“…[17][18][19][20] According to a recent meta-analysis of the literature, PEMF therapy is effective in treating postoperative pain and edema. 2 Healing bone treated with PEMF has reportedly shown an increased calcification and greater mechanical strength, 12,21,22 and these findings were confirmed by another meta-analysis. 23 PEMF therapy has been used in the field of dentistry as well, with good outcomes in various in vitro, animal, and clinical studies.…”

mentioning

confidence: 79%

See 1 more Smart Citation

Pulsed electromagnetic fields for postoperative pain: a randomized controlled clinical trial in patients undergoing mandibular third molar extraction

Stocchero

Gobbato

Biagi

et al. 2015

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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mentioning

confidence: 79%

“…1 It is also used to treat chronic wounds and facilitate bone repair processes. 2 PEMF therapy relies on short-lived emissions of electrical current, which generate an electromagnetic field in the tissues to be treated and have beneficial effects without affecting any of the main biologic functions. No side effects have been reported.…”

mentioning

confidence: 99%

Pulsed electromagnetic fields for postoperative pain: a randomized controlled clinical trial in patients undergoing mandibular third molar extraction

Stocchero

Gobbato

Biagi

et al. 2015

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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“…A meta-analysis of PEMF support efficacy in relief of traumatic, postoperative, and chronic pain in addition to edema reduction and increased wound healing potential [20]. A randomized controlled trial on the effects of PEMF therapy on nerve growth and function determined that moderate to severe itchy and burning type pain was significantly reduced with active therapy.…”

Section: Discussionmentioning

confidence: 99%

“…A meta-analysis of PEMF use reported evidence of the effectiveness of this therapy in the treatment of postoperative and non-postoperative pain and edema and wound healing [20]. Previous in vitro and in vivo studies suggest that PEMF modulates pain signaling through activation of peripheral endogenous opioids [21,22].…”

Section: Brief Review Of the Literaturementioning

confidence: 99%

A Randomized, Sham-Controlled, Double-Blind Pilot Study of Pulsed Electromagnetic Field Therapy to Evaluate Small Fiber Nerve Growth and Function and Skin Perfusion in Subjects with Painful Peripheral Diabetic Neuropathy

Aj¹,

Rp²,

Muhlenfeld³

et al. 2017

J Diabetic Complications Med

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Abstract:Purpose: The objective of this study was to determine the potential efficacy and safety of dual energy pulsed electromagnetic field therapy (PEMF) on painful distal symmetric diabetic sensorimotor polyneuropathy (DSPN).Methodology: Subjects with Type 2 diabetes and painful DSPN were randomized to receive either an active or sham PEMF device. Objective measures of efficacy (skin biopsy, nerve conduction velocity (NCV) studies, dorsal and plantar foot skin perfusion pressure (SPP) were performed prior to and following 60-days of twice daily 30 minute treatments. Patient reported outcomes included perception of pain, concomitant medication use and adverse events.Major findings: Dorsal foot SPP improved with PEMF (n=11), change from baseline=19.6 mmHg) vs. sham (n=7, change=-17.4 mmHg), p=0.03. Trends in favor of PEMF vs sham were observed for medial nerve (n=4), planter nerve (n=4) and sural nerve (n=15) onset time and amplitude (p>0.05) other than medial planter onset time (p=0.04). Although change in pain scores were similar, compliance with device use was higher in the active group compared to the sham control. The series of tests and long-term use of PEMF was well-tolerated and feasible. No device related adverse effects were recorded.Principal conclusions: Twice daily PEMF therapy was feasible, well-tolerated, and associated with trends suggesting improved nerve function and microcirculation in patients with painful DSPN. Future, large randomized controlled trials are necessary to confirm these findings and evaluate the potential longer term benefits on symptoms and pathology of DSPN.Keywords: Diabetes; Nerve conduction velocity; Peripheral neuropathy; Pulsed electromagnetic field; Skin biopsy; Skin perfusion pressure Key MessagesPainful diabetic neuropathy affects the majority of patients with diabetes during their lifetime. The presence of diabetic neuropathy increases the potential for diabetes-related lower extremity complications.The aim of this randomized, sham-controlled trial was to determine the feasibility and effects of 60 days of treatment with PEMF therapy on skin perfusion, nerve growth and function as well as pain perception, compliance and safety in subjects with painful diabetic neuropathy. Nineteen patients (12 active; 7 sham) participated in this study.This pilot study demonstrated feasibility of use and trends in favor of PEMF in nerve function and skin perfusion of the dorsal foot. Although a reduction in average pain intensity score was not observed, subjects in the active group were relatively more compliant with device use. No device adverse effects were reported.

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“…Today, RF energy is widely used for a number of applications, including production and supplementary treatment option for peripheral and central nervous system lesions, a variety of diseases and malignant tumors [2–5]. RF is also an alternative option used for treating chronic tendinopathy to reduce pain [6–10].…”

Section: Introductionmentioning

confidence: 99%

Direct Radiofrequency Application Improves Pain and Gait in Collagenase-Induced Acute Achilles Tendon Injury

Tsai

Chang

Lee

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Radiofrequency (RF) is often used as a supplementary and alternative method to alleviate pain for chronic tendinopathy. Whether or how it would work for acute tendon injury is not addressed in the literatures. Through detailed pain and gait monitoring, we hypothesized that collagenase-induce acute tendinopathy model may be able to answer these questions. Gait parameters, including time, distance, and range of motion, were recorded and analyzed using a walking track equipped with a video-based system. Expression of substance P (SP), calcitonin gene related peptide (CGRP), and galanin were used as pain markers. Beta-III tubulin and Masson trichrome staining were used as to evaluate nerve sprouting, matrix tension, and degeneration in the tendon. Of fourteen analyzed parameters, RF significantly improved stance phase, step length, preswing, and intermediary toe-spread of gait. Improved gait related to the expression of substance P, CGRP, and reduced nerve fiber sprouting and matrix tension, but not galanin. The study indicates that direct RF application may be a valuable approach to improve gait and pain in acute tendon injury. Altered gait parameters may be used as references to evaluate therapeutic outcomes of RF or other treatment plan for tendinopathy.

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Meta-Analysis of Clinical Efficacy of Pulsed Radio Frequency Energy Treatment

Abstract: On the basis of statistical evaluation of published clinical efficacy data, there is strong statistical evidence that PRFE therapy is effective in the treatment of postoperative and nonpostoperative pain and edema and in WH applications.

Cited by 48 publications

References 24 publications

Pulsed electromagnetic fields for postoperative pain: a randomized controlled clinical trial in patients undergoing mandibular third molar extraction

Pulsed electromagnetic fields for postoperative pain: a randomized controlled clinical trial in patients undergoing mandibular third molar extraction

A Randomized, Sham-Controlled, Double-Blind Pilot Study of Pulsed Electromagnetic Field Therapy to Evaluate Small Fiber Nerve Growth and Function and Skin Perfusion in Subjects with Painful Peripheral Diabetic Neuropathy

Direct Radiofrequency Application Improves Pain and Gait in Collagenase-Induced Acute Achilles Tendon Injury

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