Meta-Analysis Of Brain And Central Nervous System Microarray Datasets

Abstract

Brain and CNS cancer are rare in comparison to other types of cancer. Currently there are no effective therapies for their treatment. In this study, meta-analysis of microarray datasets of Brain and CNS cancer was done to obtain significantly upregulated genes with increased statistical power and generalizability. A total of 130 significantly up-regulated genes were obtained. Some of the genes found during analysis have not yet been associated with this cancer. Different biological networks were created and analyzed using the significantly up-regulated genes as input. For each network, the most significant pathways have also been identified computationally.