Meta-analysis of association between variation in the PDE4D gene and ischemic cerebral infarction risk in Asian populations

Xu, Xiaowei; Li, Xia; Li, Jiejie; Ou, Ruwei; Sheng, Wenli

doi:10.1007/s10048-010-0235-8

Cited by 31 publications

(20 citation statements)

References 31 publications

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“…In terms of ethnic difference, a protective effect of the ancestral T allele at SNP83 was observed only in Asian populations (ORTT = 0.79; p = 0.0005). This result is in agreement with those of Xu et al [19] .…”

Section: Discussionsupporting

confidence: 83%

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Meta-Analysis of Homogeneous Subgroups Reveals Association between <i>PDE4D</i> Gene Variants and Ischemic Stroke

Yoon¹,

Park²,

Kang³

et al. 2011

Neuroepidemiology

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Background: An Icelandic study showed a significant positive association between phosphodiesterase 4D (PDE4D) gene variants and stroke. However, subsequent studies reported conflicting results, possibly due to small sample sizes and the heterogeneity of the studies. Method: We performed a meta-analysis on 6 SNPs of the PDE4D gene to investigate the association between this gene and ischemic stroke by integrating the results of previous studies, comprising 11,834 cases and 15,233 controls. A pooled genotypic odds ratio (OR) for each SNP was determined under 3 genetic models (i.e. dominant, recessive, and codominant) using both fixed- and random-effects models with consideration for heterogeneity and publication bias across studies. Results: Among the SNPs included in this study, SNP56 (rs702553) showed the most significant association with ischemic stroke in a meta-analysis comprised of 7 homogenous studies. The overall OR of the TT genotype compared to the AA genotype was 1.29 (95% CI 1.03–1.61; p = 0.022). For SNP83 (rs966221), a protective effect of the ancestral allele T was observed only in Asian populations (ORTT 0.79, 95% CI 0.69–0.90; p = 0.0005). This meta-analysis revealed a significant association of PDE4D gene variants with the risk of ischemic stroke, and further investigations are warranted to evaluate possible ethnic-specific effects.

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Section: Discussionsupporting

confidence: 83%

“…Domingues-Monatanari et al [18] (2010) reported that none of the SNPs in the PDE4D gene was associated with ischemic stroke in the Iberian population. However, Xu et al [19] (2010) found an association between SNP83 and ischemic cerebral infarction in Asian populations.…”

mentioning

confidence: 99%

Meta-Analysis of Homogeneous Subgroups Reveals Association between <i>PDE4D</i> Gene Variants and Ischemic Stroke

Yoon¹,

Park²,

Kang³

et al. 2011

Neuroepidemiology

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“…14,[29][30][31][32] Moreover, we found a Chinese meta-analysis on Asian populations that had excluded rs12188950 from five studies regarding PDE4D gene data because of total absence of individuals with heterozygote allele pairs within that SNP. 33 A number of published studies examined SNPs in the PDE4D gene without including rs12188950. Uncommented exclusion of a SNP might cause selection bias in meta-analyses.…”

Section: Meta-analysis Findingsmentioning

confidence: 99%

A large-sample assessment of possible association between ischaemic stroke and rs12188950 in the PDE4D gene

et al. 2012

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Previous reports have shown ambiguous findings regarding the possible associations between ischaemic stroke (IS) and single nucleotide polymorphisms (SNPs) in the phosphodiesterase 4D (PDE4D) gene region. The SNP rs12188950 (or SNP45) has often been studied in this context. We performed a multi-centre study involving a large sample of 2599 IS patients and 2093 control subjects from the south and west regions of Sweden to replicate previous studies regarding IS risk and rs12188950. Subjects from Lund Stroke Register (LSR), Malmö Diet and Cancer Study (MDC) and Sahlgrenska Academy Study on Ischemic Stroke (SAHLSIS) were enroled. Subgroups of participants with hypertension and participants o55 years of age, as well as the TOAST subgroups large vessel disease, small vessel disease and cardioembolism, were also assessed. Univariate odds ratios (ORs) and ORs controlling for hypertension, diabetes and current smoking were calculated. We additionally performed a meta-analysis including 10 500 patients and 10 102 control subjects from 17 publications (including the present study). When assessing pooled data from LSR, MDC and SAHLSIS we obtained no association between IS and rs12188950 for all participants (OR¼0.93; 95% confidence interval (CI): 0.83-1.05). Significant associations were not found for hypertensive participants or participants with age o55, or when separately evaluating patients from the three different TOAST subgroups. The meta-analysis showed no significant overall estimate (OR¼0.96; 95% CI: 0.89-1.04) with significant heterogeneity for random effect (P¼0.042). No effect from rs12188950 on IS was found from either our pooled multi-centre data or the performed meta-analysis. We did not find any association between the examined subgroups and rs12188950 either.

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“…However, Yoon et al (2011) in their meta-analysis involving studies from different ethnic population reported only SNP56 to be associated with risk of IS and SNP83 to have a protective association with stroke [44]. Another study by Xu et al (2010) too reported SNP83 to be an important marker for ischemic infarction among Asians [45]. In contrast to these findings, a met-analysis carried out by Bevan …”

Section: Meta-analysis Studiesmentioning

confidence: 81%

Association between PDE4D gene and ischemic stroke: recent advancements

Das

Roy

Munshi

2015

International Journal of Neuroscience

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Stroke is a severe complication and a leading cause of death worldwide and genetic studies among different ethnicities has provided the basis for involvement of phosphodiesterase 4D (PDE4D) gene in cerebrovascular diseases. Recent advancements have evaluated the role of this gene in stroke and these studies have provided a stronger support for the involvement of this gene in stroke development and few studies also suggest that it may influence outcome. Furthermore, case-control studies and meta-analysis studies have provided strong evidence for certain variants in PDE4D to predispose to stroke only among certain ethnicities. Thus, this review focuses on recent progress made in PDE4D gene research involving genetic, molecular and pharmacological aspect. A strong conclusion has emerged that clearly indicates a pivotal role played by this gene in ischemic stroke globally. Studies have also noticeably highlighted that PDE4D gene/pathway can be a suitable drug target for managing stroke; however, a more comprehensive research is still required to understand the molecular and cellular intricacies this gene plays in stroke development, progression and its outcome.

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Meta-analysis of association between variation in the PDE4D gene and ischemic cerebral infarction risk in Asian populations

Cited by 31 publications

References 31 publications

Meta-Analysis of Homogeneous Subgroups Reveals Association between <i>PDE4D</i> Gene Variants and Ischemic Stroke

Meta-Analysis of Homogeneous Subgroups Reveals Association between <i>PDE4D</i> Gene Variants and Ischemic Stroke

A large-sample assessment of possible association between ischaemic stroke and rs12188950 in the PDE4D gene

Association between PDE4D gene and ischemic stroke: recent advancements

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