Meta-analysis of anatomic resection versus nonanatomic resection for hepatocellular carcinoma

Zhou, Yanming; Xu, Donghui; Wu, Lupeng; Li, Bin

doi:10.1007/s00423-011-0784-9

Cited by 105 publications

(78 citation statements)

References 36 publications

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“…These factors were determined before, during, and after the operation and could therefore potentially influence selection of the resection method. According to two recent meta-analyses, AR is associated with better DFS than is NAR because the poorer liver function reserve in patients who undergo NAR significantly affects the prognosis [28,29]. However, the available data remain insufficient to prove the prognostic advantage of AR because of substantial heterogeneity; the clinicopathologic features of patients who underwent AR or NAR are quite different among previous studies.…”

Section: Discussionmentioning

confidence: 99%

Comparison of anatomic and non‐anatomic hepatic resection for hepatocellular carcinoma

Kaibori

Kon

Kitawaki

et al. 2017

J Hepato Biliary Pancreat

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Background The aim of the present study was to compare the prognostic impact of anatomic resection (AR) versus non-anatomic resection (NAR) on patient survival after resection of a single hepatocellular carcinoma (HCC). Methods To control for confounding variable distributions, a 1-to-1 propensity score match was applied to compare the outcomes of AR and NAR. Among 710 patients with a primary, solitary HCC of <5.0 cm in diameter that was resectable by either AR or NAR from 2003 to 2007 in Japan and Korea, 355 patients underwent NAR and 355 underwent AR of at least one section with complete removal of the portal territory containing the tumor. Results Overall survival (OS) was better in the AR than NAR group (hazard ratio 1.67, 95% confidence interval 1.28-2.19, P < 0.001) while disease-free survival showed no significant difference. Significantly fewer patients in the AR than NAR group developed intrahepatic HCC recurrence and multiple intrahepatic recurrences. Patients with poorly differentiated HCC who underwent AR had improved disease-free survival and OS. Conclusions Anatomic resection decreases the risk of tumor recurrence and improves OS in patients with a primary, solitary HCC of <5.0 cm in diameter.

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Section: Discussionmentioning

confidence: 99%

Comparison of anatomic and non‐anatomic hepatic resection for hepatocellular carcinoma

Kaibori

Kon

Kitawaki

et al. 2017

J Hepato Biliary Pancreat

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“…49 A systematic review suggested anatomic resection of liver approves survival and diminish recurrence comparing to non-anatomical but the studies included in this meta-analysis are not randomized trials. 51 Liu PH in 2014 showed surgical resection with TACE in HCC patients beyond Milan Criteria. They had reported a noteworthy improved long term survival with surgical resection.…”

Section: Surgical Resectionmentioning

confidence: 99%

New modalities of treatment for hepatocellular carcinoma

Behnagh

Rezaei

Jahannia

et al. 2017

J. contemp. med. sci.

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Hepatocellular carcinoma (HCC) is the second most common cause of death from cancer worldwide. Managing HCC is difficult. However, there are many treatment options available such as liver transplantation, radiotherapy, different ablative techniques, surgery, trans-arterial chemoembolization (TACE) and systemic therapy. These treatments did not show the promising responses and the recurrence rate is still high. On the other hand, there are some new treatments such as immunotherapy, gene therapy, combination of different therapies, Chinese traditional therapies and new targeted therapies. The aim of this study is to review both the recent changes in the common therapies and newly developed therapies of HCC.

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“…Some studies (20)(21)(22) have demonstrated the superiority of anatomical resection over non-anatomical resection for treatment of HCC. Others (23)(24)(25) have questioned the validity of this suggestion, as they found no differences in HCC recurrence or overall survival rates for patients undergoing either form of resection after resection with curative intent.…”

Section: Anatomical Vs Non-anatomical Resectionmentioning

confidence: 99%

Recent advances in surgical treatment of hepatocellular carcinoma

Song

2015

DD&T

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Meta-analysis of anatomic resection versus nonanatomic resection for hepatocellular carcinoma

Abstract: AR was superior to NAR in terms of better survival and preventing local recurrence for the treatment of HCC.

Cited by 105 publications

References 36 publications

Comparison of anatomic and non‐anatomic hepatic resection for hepatocellular carcinoma

Comparison of anatomic and non‐anatomic hepatic resection for hepatocellular carcinoma

New modalities of treatment for hepatocellular carcinoma

Recent advances in surgical treatment of hepatocellular carcinoma

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