Meta‐analysis: <i>Lactobacillus GG</i> for treating acute diarrhoea in children

Szajewska, Hania; Skórka, Agata; Ruszczyński, Marek; Gieruszczak‐Białek, Dorota

doi:10.1111/j.1365-2036.2007.03282.x

Cited by 187 publications

(117 citation statements)

References 27 publications

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“…L. rhamnosus was selected in this study since it is a common constituent of the indigenous microbiota in the intestinal and urogenital tracts of mammals and other vertebrates and is able to balance the intestinal microbiota, inducing host immunomodulation and decreasing the symptoms of a wide range of gastrointestinal disorders (Manley et al 2007, Pant et al 2007, Szajewska et al 2007, Verdenelli et al 2009.…”

Section: Introductionmentioning

confidence: 99%

Increase of fecundity by probiotic administration in zebrafish (Danio rerio)

Gioacchini

Maradonna²,

Lombardo³

et al. 2010

Reproduction

100

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It is well known established that reproduction is sensitive to the state of energy reserves, and that there is a balance between energy homeostasis and fertility. In this view, this study examined the effects of the probiotic Lactobacillus rhamnosus, as a feed additive, on zebrafish (Danio rerio) fecundity. Ten days of probiotic treatment modulate the gene expression of neuropeptide hormones and metabolic signals, such as kiss1, kiss2 and leptin both at the CNS level and at the peripheral level. The increase in fecundity brought about by the probiotic was demonstrated by the higher number of ovulated eggs in vivo and by the higher germinal vesicle breakdown rate obtained with the in vitro maturation assay. The increase in oocyte maturation was associated with increased transcription of genes coding for signals which induce the maturation phase, such as lhcgr, cbr1l, and paqr8 genes, concomitant with a decreased transcription of genes coding for local factors which prevent oocyte maturation, such as tgfb1, gdf9, and bmp15. In conclusion, all these findings highlight the action of L. rhamnosus both on the endocrine system and at the local level by inducing oocyte maturation. The significance of the results herein obtained underlined the importance of diet in the reproductive process, supporting the hypothesis that feed additives can improve fecundity. Considering that the zebrafish has been clearly established as a vertebrate model for biomedical research, these results support the potentiality of feed additives such as probiotics, frequently used in the human diet, as a new technology to improve reproduction in all vertebrates, including humans.

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Section: Introductionmentioning

confidence: 99%

Increase of fecundity by probiotic administration in zebrafish (Danio rerio)

Gioacchini

Maradonna²,

Lombardo³

et al. 2010

Reproduction

100

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“…11 Probiotics are well studied for their health benefits in improving immune system function 12 and preventing diarrhea. 13,14 It has also been demonstrated that probiotics and their products can improve BP through mechanisms including improving total cholesterol and low-density lipoprotein cholesterol levels, [15][16][17] reducing blood glucose level and insulin resistance, 18,19 and regulating the renin-angiotensin system. 20,21 A recent systematic review and meta-analysis of 14 randomized, controlled trials showed that consumption of fermented milk containing inhibitory peptides (with or without probiotics) can significantly reduce SBP and DBP.…”

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confidence: 99%

Effect of Probiotics on Blood Pressure

et al. 2014

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Abstract-Previous human clinical trials have shown that probiotic consumption may improve blood pressure (BP) control.The aim of the present systematic review was to clarify the effects of probiotics on BP using a meta-analysis of randomized, controlled trials. PubMed, Scopus, Cochrane Library (Central), Physiotherapy Evidence Database, and Clinicaltrial.gov databases were searched until January 2014 to identify eligible articles. Meta-analysis using a random-effects model was chosen to analyze the impact of combined trials. Nine trials were included. Probiotic consumption significantly changed systolic BP by −3.56 mm Hg (95% confidence interval, −6.46 to −0.66) and diastolic BP by −2.38 mm Hg (95% confidence interval, −2.38 to −0.93) compared with control groups. A greater reduction was found with multiple as compared with single species of probiotics, for both systolic and diastolic BP. Subgroup analysis of trials with baseline BP ≥130/85 mm Hg compared with <130/85 mm Hg found a more significant improvement in diastolic BP. Duration of intervention <8 weeks did not result in a significant reduction in systolic or diastolic BP. Furthermore, subgroup analysis of trials with daily dose of probiotics <10 11 colony-forming units did not result in a significant meta-analysis effect. The present meta-analysis suggests that consuming probiotics may improve BP by a modest degree, with a potentially greater effect when baseline BP is elevated, multiple species of probiotics are consumed, the duration of intervention is ≥8 weeks, or daily consumption dose is ≥10 The online-only Data Supplement is available with this article at http://hyper.ahajournals.org/lookup/suppl

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“…16 Some studies have also reported that probiotic treatment significantly reduce the severity and duration of illness, compared to other therapies. [17][18][19] Probiotics can be effective by regulating inflammatory cytokines. Since the duration of viral diarrhea is directly related to the treatment of intestinal tissue inflammation, probiotics can be very effective in combination with other treatments.…”

Section: Discussionmentioning

confidence: 99%

Effect of probiotic supplement (kidilact) on prevention of acute diarrhea in children: a double-blind randomized clinical trial

Hesaraki

2017

Int J Res Med Sci

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Background: Acute viral diarrhea is one of the most common diseases in children, which is associated with high risk of mortality. The present study aimed to determine the effect of Kidilact on the treatment of children with acute diarrhea.Methods: This double-blind randomized clinical trial was conducted on 84 children aged 6-60 months with diarrhea, hospitalized in pediatric ward of Amir al-Mu'minin hospital of Zabol, Iran. The patients who met the inclusion criteria were included and assigned to the control and treatment groups (42 patients in each group). Data collection instruments included clinical examination of participants in terms of gender, medication, diet, stool test, weight, average heart rate, average respiratory rate, average body temperature, and average frequency of defecation Data was analyzed with descriptive and analytical tests (chi-square, Fisher's exact test, t-test, etc.) in SPSS-21.Results: Body temperature, heart rate, and frequency of defecation significantly reduced in the intervention group after three days (p<0.05). In addition, weight gain presented an improving trend in the intervention group, but not significantly different from the control group (p<0.05).Conclusions: Findings indicated that the use of Kidilact may be helpful in the treatment of acute viral diarrhea in children and play a key role in early recovery, reduction of disease severity, and improvement of vital signs in these patients.

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Meta‐analysis: Lactobacillus GG for treating acute diarrhoea in children

Cited by 187 publications

References 27 publications

Increase of fecundity by probiotic administration in zebrafish (Danio rerio)

Increase of fecundity by probiotic administration in zebrafish (Danio rerio)

Effect of Probiotics on Blood Pressure

Effect of probiotic supplement (kidilact) on prevention of acute diarrhea in children: a double-blind randomized clinical trial

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