Meta‐analysis evidence of a differential risk of the FCRL3 −169T→C polymorphism in white and East Asian rheumatoid arthritis patients

Replication of reported genetic associations of PADI4, FCRL3, SLC22A4 and RUNX1 genes with rheumatoid arthritis: results of an independent Japanese population and evidence from meta-analysis of East Asian studies

“…Third, the magnitudes of individual effects were likely to be much weaker than those reported in the first positive reports. In addition, the updated allele fixed-effects summary OR for rs7528684/ fcrl3_3 was 1.16, showing a trend toward a decrease as compared with an OR of 1.20 for East Asian subjects, provided by a previously published meta-analysis (Begovich et al 2007). These are perhaps because the risk effects may have been overestimated in the first reports, consistent with a phenomenon known as the ''winner's curse'' effect (Lohmueller et al 2003 Fig.…”

“…Several studies have assessed the role of fcrl3_3 in the development of RA in Caucasians, and many failed to replicate the earlier results (Martinez et al 2006a;Eyre et al 2006;Newman et al 2006;Thabet et al 2007). A recent meta-analysis involving more than 10,000 white subjects provided no evidence of association (Begovich et al 2007).…”

Genetic association study of polymorphisms FOXP3 and FCRL3 in women with endometriosis

“…Moreover, looking carefully at these findings, a progression of disease risk was observed according to the presence of one or two copies of the FCRL3 risk allele (risk allele C) and the FOXP3 CT genotype (risk allele T) polymorphisms. Yet, although the FCRL3 polymorphic allele is allele ''T,'' the actual risk allele is allele ''C,'' and an increased level of the FCRL3 protein, which is correlated with the À169C susceptibility allele, may result in B-cell abnormalities and higher levels of antibodies, leading to a greater tendency to develop autoimmune diseases (15,(21)(22)(23)(24)(25). The results of the OR analysis (FCRL3TT/FOXP3CT OR ¼ 2.14; FCRL3CT/FOXP3CT OR ¼ 3.25, and FCRL3CT/FOXP3CT OR ¼ 6.00) showed that different combinations of the two genotypes increased the risk of endometriosis development.…”

“…Therefore, an increased level of FCRL3 protein, which is correlated with the À169C susceptibility allele, may result in B-cell abnormalities and higher levels of antibodies. Consequently, individuals with this allele may have a greater tendency to develop autoimmune diseases (15,(21)(22)(23)(24)(25).…”

FCRL3 gene polymorphisms contribute to the radiographic severity rather than susceptibility of rheumatoid arthritis

“…Recently, a number of single nucleotide polymorphisms (SNPs) have been described in the FCRL3 gene [5,6,[13][14][15][16][17][18][19][20][21][22]. In a Japanese case-control study involving the SNP-based linkage disequilibrium (LD) mapping of a 16-Mb region on 1q21-23, the strongest association with RA was observed in the 4 SNPs located within the FCRL3 gene [5].…”