Meta-Analysis Evaluating H2FPEF Score as a Prognostic Tool to Predict Mortality and Heart Failure–Related Hospitalization in Adults With Normal Left Ventricular Ejection Fraction and Dyspnea

Rio‐Pertuz, Gaspar Del; Benjanuwattra, Juthipong; Juarez, Michel; Triana, Abel; Argueta-Sosa, Erwin

doi:10.1016/j.amjcard.2022.03.046

Cited by 3 publications

(3 citation statements)

References 10 publications

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“…In clinical studies in relevant animal models, diabetes causes myocardial steatosis, increasing the thickness of the left ventricular wall, which in turn induces centripetal remodelling of the left ventricle. This process is one of the physiological processes contributing to the development of HF (21,22).…”

Section: Discussionmentioning

confidence: 99%

. Significance of Plasma TGF-β1 Level Detection in Patients with T2DM with Heart Failure

Sun

2024

J Med Biochem

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Abstracts: Objective: To examine the significance of plasma Transforming Growth Factor-1/TGF-1 (TGF-1) level testing in patients with Type 2 Diabetes Mellitus (T2DM) and heart failure. Methods: A sample of T2DM patients who were hospitalised for dyspnea between June 2021 and June 2023 were chosen. Based on the convenience sample approach, 150 cases were screened for the study, and 50 healthy non-diabetic people without cardiac problems who completed physical examinations over the same period were included as a control group. All study participants had their serum NT-proBNP and plasma TGF-I levels checked, and the values between the two groups were compared. Then, the patients with T2DM with heart failure were grouped according to whether they were accompanied by heart failure or not and the grading of cardiac function, and then the serum NT-proBNP and plasma TGF-β1 levels were compared between the different groups of patients. The diagnostic value of plasma TGF-β1 in the occurrence of heart failure in patients with T2DM was analysed. Results: There were 54 patients without heart failure and 96 people with heart failure among the 150 T2DM patients. The cut-off point was 44.50 g/L. At this time, the sensitivity and specificity for the diagnosis of concomitant heart failure in T2DM were 79.63% and 52.51%, respectively. 96 individuals with T2DM and heart failure showed greater serum and plasma levels of NT-proBNP and TGF-1 compared to the other two groups (P 0.05). ProBNP levels and plasma TGF-1 levels had a positive and significant relationship (P 0.05). Conclusion: Plasma TGF-1 levels were much higher in T2DM patients than in the general population, and the increase in this index was more pronounced in patients who also had heart failure, which is a diagnostic indicator for T2DM and heart failure.

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Section: Discussionmentioning

confidence: 99%

. Significance of Plasma TGF-β1 Level Detection in Patients with T2DM with Heart Failure

Sun

2024

J Med Biochem

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“…34 A portion of studies examined the value of the H 2 FPEF and HFA-PEFF scores for predicting unfavourable outcomes in HFpEF patients, and the conclusions are not consistent. Most studies have shown that both tools can be used to assessing HFpEF prognosis, 35,36 and higher scores are associated with more all-cause mortality and rehospitalisation, [37][38][39][40] including in patients with cardiac valve surgery or cardiac amyloidosis. [41][42][43] Compared to HFA-PEFF algorithm, H 2 FPEF score can also be useful to predetermine cardiovascular and HF-related events.…”

Section: Prognosis Of Hfpefmentioning

confidence: 99%

Combination of SVI/S′ and diagnostic scores for heart failure with preserved ejection fraction

Wang

Liu

et al. 2023

Clin Exp Pharma Physio

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The diagnosis of heart failure with preserved ejection fraction (HFpEF) remains a challenge. There are three methods proposed as diagnostic tools. H 2 FPEF score was determined by six weighted clinical characteristics and echocardiographic variables. Heart Failure Association (HFA)-PEFF algorithm consists of various functional and morphological variables as well as natriuretic peptides. SVI/S 0 is a novel echocardiographic parameter calculated by stroke volume index and mitral annulus systolic peak velocity. This study aimed to compare the three approaches in patients with suspected HFpEF.

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“… 20 The HFA‐PEFF score is more complicated and evaluates natriuretic peptide levels and echocardiographic findings of cardiac function and structure. 16 Both appear to have diagnostic and prognostic value, 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 although H 2 FPEF may be better at predicting exercise intolerance. 32 Recently, the HFA‐PEFF score was used to identify 4 distinct phenogroups in “early‐HFpEF” patients of increasing severity: (1) no LV diastolic dysfunction, (2) LV diastolic dysfunction with functional LV abnormalities; (3) LV diastolic dysfunction with functional and structural LV abnormalities, and (4) LV diastolic dysfunction with functional and structural LV abnormalities and elevated B‐type natriuretic peptide.…”

Section: Clinical Aspectsmentioning

confidence: 99%

Genomic, Proteomic, and Metabolic Comparisons of Small Animal Models of Heart Failure With Preserved Ejection Fraction: A Tale of Mice, Rats, and Cats

Smith

Altara

Amin

et al. 2022

JAHA

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Heart failure with preserved ejection fraction (HFpEF) remains a medical anomaly that baffles researchers and physicians alike. The overall phenotypical changes of diastolic function and left ventricular hypertrophy observed in HFpEF are definable; however, the metabolic and molecular alterations that ultimately produce these changes are not well established. Comorbidities such as obesity, hypertension, and diabetes, as well as general aging, play crucial roles in its development and progression. Various animal models have recently been developed to better understand the pathophysiological and metabolic developments in HFpEF and to illuminate novel avenues for pharmacotherapy. These models include multi‐hit rodents and feline aortic constriction animals. Recently, genomic, proteomic, and metabolomic approaches have been used to define altered signaling pathways in the heart associated with HFpEF, including those involved in inflammation, cGMP‐related, Ca 2+ handling, mitochondrial respiration, and the unfolded protein response in endoplasmic reticulum stress. This article aims to present an overview of what has been learnt by these studies, focusing mainly on the findings in common while highlighting unresolved issues. The knowledge gained from these research models will not simply be of benefit for treating HFpEF but will undoubtedly provide new insights into the mechanisms by which the heart deals with external stresses and how the processes involved can fail.

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Meta-Analysis Evaluating H2FPEF Score as a Prognostic Tool to Predict Mortality and Heart Failure–Related Hospitalization in Adults With Normal Left Ventricular Ejection Fraction and Dyspnea

Cited by 3 publications

References 10 publications

. Significance of Plasma TGF-β1 Level Detection in Patients with T2DM with Heart Failure

. Significance of Plasma TGF-β1 Level Detection in Patients with T2DM with Heart Failure

Combination of SVI/S′ and diagnostic scores for heart failure with preserved ejection fraction

Genomic, Proteomic, and Metabolic Comparisons of Small Animal Models of Heart Failure With Preserved Ejection Fraction: A Tale of Mice, Rats, and Cats

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