Meta‐analysis: clinicopathological and prognostic significance of cyclooxygenase‐2 expression on oesophageal squamous cell carinoma

Li, L.; Wu, Ziying; Wang, G.; Chen, G.

doi:10.1111/j.1365-2036.2009.04069.x

Cited by 16 publications

(11 citation statements)

References 28 publications

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“…Our result was consistent with previous meta-analysis conducted by Li et al45 In previous meta-analysis, they only focus on ESCC and their literature search time was closed on December 2008. Our meta-analysis included more studies and larger sample size to comprehensively evaluate the prognostic and clinicopathological significance of COX-2 expression in patients with EC (including ESCC and EADC).…”

Section: Discussionsupporting

confidence: 92%

The prognostic value of cyclooxygenase-2 expression in patients with esophageal cancer: evidence from a meta-analysis

Hu¹,

Yang

Zhao

et al. 2017

OTT

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Published studies have investigated the prognostic role of cyclooxygenase-2 (COX-2) expression in patients with esophageal cancer (EC), but the result remains controversial. Thus, this meta-analysis was conducted to comprehensively evaluate the impact of COX-2 expression on the prognostic value in patients with EC. Relevant studies were identified from PubMed, EMBASE, and Web of Science databases. Studies that detected the COX-2 expression by immunohistochemistry and evaluated the relationship between COX-2 expression and overall survival (OS) or clinicopathological parameters were used in our analysis. The summary hazard ratios (HRs) or odds ratios were calculated to assess the risk or hazard association. A total of 25 studies, which included 2,465 patients, were included in our meta-analysis. Our analysis suggested that overexpression of COX-2 was associated with poor OS (HR =1.60, 95% CI =1.32–1.94, P<0.001). Subgroup analyses by race, percentage of high/positive COX-2 expression, histology type, treatment, and sample size all suggested significant association. Moreover, overexpression of COX-2 was significantly associated with depth of invasion, lymph node metastasis, distant metastasis, and TNM stage. This meta-analysis suggested that overexpression of COX-2 might serve as a prognostic biomarker for EC. Large well-designed prospective studies are needed to confirm our conclusion.

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Section: Discussionsupporting

confidence: 92%

The prognostic value of cyclooxygenase-2 expression in patients with esophageal cancer: evidence from a meta-analysis

Hu¹,

Yang

Zhao

et al. 2017

OTT

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“…There were several meta-analyses studying the prognostic value of COX-2 in other cancer types, such as lung cancer and esophageal cancer [29], [30]. The results suggest COX-2 could be of importance in early-stage NSCLC, and its impact might be lost at later steps because of the potential interaction with many factors [29].…”

Section: Discussionmentioning

confidence: 99%

Prognostic Significance of COX-2 Immunohistochemical Expression in Colorectal Cancer: A Meta-Analysis of the Literature

et al. 2013

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BackgroundCyclooxygenase-2 (COX-2) is believed to be an important enzyme in the pathogenesis of colorectal cancer (CRC). Correlations between the expression of COX-2 with tumor growth and distant metastasis have become an issue; thus, attention has been paid to COX-2 as a prognostic factor. Various studies examined the relationship between COX-2 immunohistochemistry (IHC) overexpression with the clinical outcome in patients with colorectal cancer, but yielded conflicting results. The prognostic significance of COX-2 overexpression in colorectal cancer remains controversial.MethodsElectronic databases updated to October 2012 were searched to find relevant studies. A meta-analysis was conducted with eligible studies which quantitatively evaluated the relationship between COX-2 overexpression and survival of patients with colorectal cancer. Survival data were aggregated and quantitatively analyzed.ResultsWe performed a meta-analysis of 23 studies (n = 4567 patients) that evaluated the correlation between COX-2 overexpression detected by IHC and survival in patients with colorectal cancer. Combined hazard ratios suggested that COX-2 overexpression had an unfavorable impact on overall survival (OS) (HR [hazard ratio] = 1.193, 95% CI [confidence interval]: 1.02 ∼ 1.37), but not disease free survival (DFS) (HR = 1.25, 95% CI: 0.99 ∼ 1.50) in patients with colorectal cancer.ConclusionsCox-2 overexpression in colorectal cancer detected by IHC appears to have slightly worse overall survival. However, the prognostic value of COX-2 on survival in colorectal cancer still needs further large-scale prospective trials to be clarified.

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“…Recently, we reported that PLA2G2A and COX-2 gene single nucleotide polymorphisms (SNPs) (Liu et al, 2014). However, the relationship between PLA2G2A and COX-2 protein expression and ESCC clinical features remains controversial in the literature (Li et al, 2009;Ren et al, 2013). Moreover, a correlation between the co-expression of PLA2G2A and COX-2 in ESCC has not yet been reported.…”

Section: Introductionmentioning

confidence: 99%

Overexpression of Phospholipase A₂Group IIA in Esophageal Squamous Cell Carcinoma and Association with Cyclooxygenase-2 Expression

Zhai¹,

Dong²,

Wang³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Asian Pac J Cancer Prev, 15 (21), 9417-9421 IntroductionEsophageal cancer is a highly aggressive malignant disease with a 5-year survival rate of 10% to 15% (Ferri et al., 2012). The incidence of esophageal cancer varies greatly between populations and across geographic regions. The Taihangshan Mountain area, including Linxian in Henan Province, a rural area of China, has the highest incidence of esophageal cancer, especially squamous cell carcinoma (ESCC), in the world (>100 per 100, 000 population) (Zhang et al., 2011;Lin et al., 2013).Inflammation has been recognized as a contributing factor for the pathogenesis of ESCC. There are results showing that two key inflammatory enzymes, Phospholipase A 2 Group IIA (PLA2G2A) and cyclooxygenase-2 (COX-2) are involved in the pathways of arachidonic acid (AA) biosynthesis, and both play an important role in inflammation and angiogenesis as well as cancer (Murakami et al., 2011). Recently, we reported that PLA2G2A and COX-2 gene single nucleotide polymorphisms (SNPs) may modify the risk of ESCC

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Meta‐analysis: clinicopathological and prognostic significance of cyclooxygenase‐2 expression on oesophageal squamous cell carinoma

Abstract: SUMMARY BackgroundCyclooxygenase-2 (COX-2) is involved in oesophageal carcinogenesis, but the clinical and prognostic significance of COX-2 expression in oesophageal squamous cell carcinoma (ESCC) remains controversial.

Cited by 16 publications

References 28 publications

The prognostic value of cyclooxygenase-2 expression in patients with esophageal cancer: evidence from a meta-analysis

The prognostic value of cyclooxygenase-2 expression in patients with esophageal cancer: evidence from a meta-analysis

Prognostic Significance of COX-2 Immunohistochemical Expression in Colorectal Cancer: A Meta-Analysis of the Literature

Overexpression of Phospholipase A₂Group IIA in Esophageal Squamous Cell Carcinoma and Association with Cyclooxygenase-2 Expression

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Meta‐analysis: clinicopathological and prognostic significance of cyclooxygenase‐2 expression on oesophageal squamous cell carinoma

Abstract: SUMMARY BackgroundCyclooxygenase-2 (COX-2) is involved in oesophageal carcinogenesis, but the clinical and prognostic significance of COX-2 expression in oesophageal squamous cell carcinoma (ESCC) remains controversial.

Cited by 16 publications

References 28 publications

The prognostic value of cyclooxygenase-2 expression in patients with esophageal cancer: evidence from a meta-analysis

The prognostic value of cyclooxygenase-2 expression in patients with esophageal cancer: evidence from a meta-analysis

Prognostic Significance of COX-2 Immunohistochemical Expression in Colorectal Cancer: A Meta-Analysis of the Literature

Overexpression of Phospholipase A2Group IIA in Esophageal Squamous Cell Carcinoma and Association with Cyclooxygenase-2 Expression

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Overexpression of Phospholipase A₂Group IIA in Esophageal Squamous Cell Carcinoma and Association with Cyclooxygenase-2 Expression