2007
DOI: 10.1111/j.1365-2036.2007.03241.x
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Meta‐analysis: cancer risk of low‐grade dysplasia in chronic ulcerative colitis

Abstract: SUMMARY BackgroundThe cancer risk of low-grade dysplasia (LGD) in chronic ulcerative colitis is variable and its management remain contentious.

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Cited by 235 publications
(158 citation statements)
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“…Furthermore, almost one-third of patients with low grade dysplasia progressed to high grade dysplasia or cancer during follow-up. In the most recent meta-analysis, low-grade dysplasia was found to be associated with a 9-fold increased risk of developing CRC and a 12-fold risk of developing advanced neoplasia [66] . However, because some follow-up studies of patients with low-grade dysplasia have shown a low rate of CRC development (2%-10% during a 10-year followup) [67] , it seems there is a reasonable compromise to continue surveillance with extensive biopsy sampling at shorter intervals (e.g.…”
Section: Endoscopic Surveillance In Ibdmentioning
confidence: 99%
“…Furthermore, almost one-third of patients with low grade dysplasia progressed to high grade dysplasia or cancer during follow-up. In the most recent meta-analysis, low-grade dysplasia was found to be associated with a 9-fold increased risk of developing CRC and a 12-fold risk of developing advanced neoplasia [66] . However, because some follow-up studies of patients with low-grade dysplasia have shown a low rate of CRC development (2%-10% during a 10-year followup) [67] , it seems there is a reasonable compromise to continue surveillance with extensive biopsy sampling at shorter intervals (e.g.…”
Section: Endoscopic Surveillance In Ibdmentioning
confidence: 99%
“…When low grade dysplasia was detected on colonoscopy it was associated with a nine fold increased risk of developing CRC, and 12 fold risk of developing advanced lesions. For patients who opt to avoid colectomy and prefer continued surveillance of flat dysplasia, according to this meta-analysis the positive predictive value for progression to high grade dysplasia or CRC is approximately 14.6% (Thomas et al, 2007). Other studies list rates of progression to neoplasia ranging from 33% to 54% (Rutter et al, 2006;Ullman et al, 2002).…”
Section: Flat Dysplasiamentioning
confidence: 94%
“…In the event that flat high grade dysplasia is noted anywhere in the colon and confirmed by an expert gastrointestinal pathologist, colectomy is the treatment of choice (Farraye et al, 2010;Thomas et al, 2007). Similarly, multifocal low grade dysplasia is also considered a strong indication for colectomy.…”
Section: Management Of Dysplastic Lesionsmentioning
confidence: 99%
“…A meta-analysis study reported that 22% of invisible LGD harbored synchronous colorectal carcinoma on immediate colectomy. 106 However, emerging evidence suggests that, using more advanced technology such as chromoendoscopy or high-definition white-light colonoscopy, about 90% of dysplasia in IBD is indeed visible. 95 Therefore, the 2015 SCENIC consensus recommends that patients with endoscopically invisible dysplasia-biopsies with unexpected dysplasia that was not visible on endoscopy-that is confirmed by a GI pathologist should be referred to an endoscopist with expertise in IBD surveillance using chromoendoscopy with high-definition colonoscopy.…”
Section: Management Of Nonpolypoid Dysplasiamentioning
confidence: 99%