Meta‐analysis and transcriptomic analysis reveal that NKRF and ZBTB17 regulate the NF‐κB signaling pathway, contributing to the shared molecular mechanisms of Alzheimer's disease and atherosclerosis
Di Zhang,
Keyan Chen,
Li Shen Shan
Abstract:IntroductionAlzheimer's disease (AD) and atherosclerosis (AS) are widespread diseases predominantly observed in the elderly population. Despite their prevalence, the underlying molecular interconnections between these two conditions are not well understood.MethodsUtilizing meta‐analysis, bioinformatics methodologies, and the GEO database, we systematically analyzed transcriptome data to pinpoint key genes concurrently differentially expressed in AD and AS. Our experimental validations in mouse models highlight… Show more
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